(73 nodes) Negative regulation of protein-containing complex disassembly network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (277 aa)
	SPEF1	Sperm flagellar 1. (219 aa)
	CLASP1	Uncharacterized protein. (66 aa)
	M3XGX9_LATCH	Uncharacterized protein. (185 aa)
	H3BGE7_LATCH	Uncharacterized protein. (73 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2288 aa)
	AVIL	Advillin. (873 aa)
	CAPZA1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (292 aa)
	SPTBN5	Spectrin beta, non-erythrocytic 5. (3576 aa)
	H3BEF8_LATCH	Cytoplasmic linker associated protein 1a. (1413 aa)
	HDGFL3	HDGF like 3. (203 aa)
	H3BDJ8_LATCH	Spectrin beta chain; Belongs to the spectrin family. (2316 aa)
	ADD2	Adducin 2. (742 aa)
	SPTB	Spectrin beta chain; Belongs to the spectrin family. (2351 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	CIB1	Calcium and integrin binding 1. (190 aa)
	MAP6D1	MAP6 domain containing 1. (270 aa)
	SVIL	Supervillin. (2196 aa)
	TWF1	Twinfilin actin binding protein 1. (351 aa)
	ATXN7L2	Ataxin 7 like 2. (745 aa)
	CAMSAP1	Calmodulin regulated spectrin associated protein 1. (1614 aa)
	STMN2	Stathmin; Belongs to the stathmin family. (179 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (624 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1509 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	MID1IP1	MID1 interacting protein 1. (159 aa)
	TMOD1	Tropomodulin 1. (361 aa)
	SCAF4	SR-related CTD associated factor 4. (1077 aa)
	LMOD3	Leiomodin 3. (551 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2494 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2278 aa)
	ADD1	Adducin 1. (805 aa)
	LMOD2	Leiomodin 2. (544 aa)
	RUBCN	Rubicon autophagy regulator. (924 aa)
	TMOD4	Tropomodulin 4. (353 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	LMOD1	Leiomodin 1. (603 aa)
	CAMSAP2	Calmodulin regulated spectrin associated protein family member 2. (1347 aa)
	H3ASN6_LATCH	HP domain-containing protein. (111 aa)
	TMEM39B	Transmembrane protein 39B. (487 aa)
	UBQLN4	Ubiquilin 4. (636 aa)
	GSN	Gelsolin. (757 aa)
	CLEC16A	C-type lectin domain containing 16A. (610 aa)
	LIMA1	LIM domain and actin binding 1. (545 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2366 aa)
	FLII	FLII actin remodeling protein. (1259 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1027 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	H3ADA2_LATCH	Uncharacterized protein. (75 aa)
	LOC102367195	HP domain-containing protein. (741 aa)
	LOC102360693	FERM domain-containing protein. (560 aa)
	LOC102351334	Scinderin like a. (721 aa)
	CLASP2	Cytoplasmic linker associated protein 2. (1303 aa)
	APC	APC regulator of WNT signaling pathway. (2802 aa)
	CAMSAP3	Calmodulin regulated spectrin associated protein family member 3. (1261 aa)
	TMOD3	Tropomodulin 3. (352 aa)
	CAPG	Capping actin protein, gelsolin like. (349 aa)
	H3A0R5_LATCH	Zgc:171844. (201 aa)
	CAPZA3	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (285 aa)
	BMERB1	BMERB domain containing 1. (142 aa)
	ATXN7L1	Ataxin 7 like 1. (836 aa)
	LOC102357296	FPL domain-containing protein. (365 aa)
	ADD3	Adducin 3. (702 aa)
	TMEM39A	Transmembrane protein 39A. (318 aa)
	SCAF8	SR-related CTD associated factor 8. (1071 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (546 aa)
	TTBK2	Tau tubulin kinase 2. (1233 aa)
	VIL1	Villin 1. (832 aa)
	H2ZTF5_LATCH	SCA7 domain-containing protein. (575 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	SCIN	Scinderin. (632 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	ADD2	ENSLACP00000014663	ENSLACP00000019654	Adducin 1.	Adducin 2.	0.979
ADD1	ADD3	ENSLACP00000014663	ENSLACP00000001781	Adducin 1.	Adducin 3.	0.968
ADD1	CAPZB	ENSLACP00000014663	ENSLACP00000008482	Adducin 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.508
ADD1	DMTN	ENSLACP00000014663	ENSLACP00000019018	Adducin 1.	Dematin actin binding protein.	0.877
ADD1	TMOD1	ENSLACP00000014663	ENSLACP00000016388	Adducin 1.	Tropomodulin 1.	0.465
ADD1	TMOD3	ENSLACP00000014663	ENSLACP00000005031	Adducin 1.	Tropomodulin 3.	0.517
ADD1	TMOD4	ENSLACP00000014663	ENSLACP00000013837	Adducin 1.	Tropomodulin 4.	0.465
ADD2	ADD1	ENSLACP00000019654	ENSLACP00000014663	Adducin 2.	Adducin 1.	0.979
ADD2	CAPZB	ENSLACP00000019654	ENSLACP00000008482	Adducin 2.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.491
ADD2	DMTN	ENSLACP00000019654	ENSLACP00000019018	Adducin 2.	Dematin actin binding protein.	0.885
ADD2	TMOD1	ENSLACP00000019654	ENSLACP00000016388	Adducin 2.	Tropomodulin 1.	0.455
ADD2	TMOD3	ENSLACP00000019654	ENSLACP00000005031	Adducin 2.	Tropomodulin 3.	0.529
ADD2	TMOD4	ENSLACP00000019654	ENSLACP00000013837	Adducin 2.	Tropomodulin 4.	0.455
ADD3	ADD1	ENSLACP00000001781	ENSLACP00000014663	Adducin 3.	Adducin 1.	0.968
ADD3	CAPZB	ENSLACP00000001781	ENSLACP00000008482	Adducin 3.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.491
ADD3	DMTN	ENSLACP00000001781	ENSLACP00000019018	Adducin 3.	Dematin actin binding protein.	0.877
ADD3	TMOD1	ENSLACP00000001781	ENSLACP00000016388	Adducin 3.	Tropomodulin 1.	0.456
ADD3	TMOD3	ENSLACP00000001781	ENSLACP00000005031	Adducin 3.	Tropomodulin 3.	0.510
ADD3	TMOD4	ENSLACP00000001781	ENSLACP00000013837	Adducin 3.	Tropomodulin 4.	0.456
AVIL	TWF1	ENSLACP00000020633	ENSLACP00000018579	Advillin.	Twinfilin actin binding protein 1.	0.491