(75 nodes) Regulation of carbohydrate biosynthetic process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1695 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	H3APJ3_LATCH	Dimer_Tnp_hAT domain-containing protein. (226 aa)
	LOC102365364	Cryptochrome circadian regulator 3a. (616 aa)
	H3ARI5_LATCH	Uncharacterized protein. (417 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	H3ASZ0_LATCH	Uncharacterized protein. (205 aa)
	H3AV95_LATCH	DUF4371 domain-containing protein. (559 aa)
	SLC35B4	Solute carrier family 35 member B4. (331 aa)
	H3AWN2_LATCH	Cryptochrome circadian regulator 4. (531 aa)
	H3AWY0_LATCH	Uncharacterized protein. (559 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
	H3AZ56_LATCH	Dimer_Tnp_hAT domain-containing protein. (458 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	MAS1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa)
	PPP1R3G	CBM21 domain-containing protein. (231 aa)
	H3B6H7_LATCH	Dimer_Tnp_hAT domain-containing protein. (246 aa)
	H3B749_LATCH	Uncharacterized protein. (360 aa)
	PLEK	Pleckstrin. (353 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	H3BBU7_LATCH	Uncharacterized protein. (127 aa)
	DGKQ	Diacylglycerol kinase. (940 aa)
	ZNF692	Zinc finger protein 692. (530 aa)
	H3A536_LATCH	Uncharacterized protein. (167 aa)
	LOC102345465	Uncharacterized protein. (347 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	LOC102350947	G_PROTEIN_RECEP_F1_2 domain-containing protein. (327 aa)
	H3A6C6_LATCH	Dimer_Tnp_hAT domain-containing protein. (210 aa)
	USP7	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3E. (294 aa)
	H3A2Y4_LATCH	Protein phosphatase 1 regulatory subunit. (319 aa)
	H3A113_LATCH	Dimer_Tnp_hAT domain-containing protein. (167 aa)
	H3A0C4_LATCH	Uncharacterized protein. (204 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	H2ZZS8_LATCH	Uncharacterized protein. (346 aa)
	H2ZYP2_LATCH	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (305 aa)
	H2ZY15_LATCH	Uncharacterized protein. (481 aa)
	H3BGZ2_LATCH	Uncharacterized protein. (176 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1651 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	H3BFB7_LATCH	Uncharacterized protein. (489 aa)
	DDB1	Damage specific DNA binding protein 1. (1142 aa)
	AP2A1	Alpha_adaptinC2 domain-containing protein. (737 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit 3D. (307 aa)
	FAM3A	Family with sequence similarity 3 member A. (227 aa)
	H2ZXA8_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (339 aa)
	H2ZWP1_LATCH	Dimer_Tnp_hAT domain-containing protein. (525 aa)
	H2ZVZ2_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (340 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (657 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (319 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa)
	FAM3C	Family with sequence similarity 3 member C. (134 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	H3AEX8_LATCH	CBM21 domain-containing protein. (304 aa)
	H3AFG3_LATCH	Dimer_Tnp_hAT domain-containing protein. (202 aa)
	H3AFH7_LATCH	Uncharacterized protein. (364 aa)
	H3AFI1_LATCH	Uncharacterized protein. (241 aa)
	LEPR	Leptin receptor. (1149 aa)
	SIRT6	Sirtuin 6. (375 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	CRY1	Cryptochrome circadian regulator 1. (653 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (424 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	SIRT7	Sirtuin 7. (413 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1695 aa)
	H3AN32_LATCH	Uncharacterized protein. (3251 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (707 aa)
	C1QTNF12	C1q and TNF related 12. (265 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADM	PPARA	ENSLACP00000009742	ENSLACP00000012397	Acyl-CoA dehydrogenase medium chain.	Peroxisome proliferator activated receptor alpha.	0.552
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LEPR	ENSLACP00000000452	ENSLACP00000008593	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.554
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	PPARA	ENSLACP00000000452	ENSLACP00000012397	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.654
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
AP2A1	CLTC	ENSLACP00000019999	ENSLACP00000011035	Alpha_adaptinC2 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.918
AP2A1	CLTCL1	ENSLACP00000019999	ENSLACP00000010273	Alpha_adaptinC2 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.918
C1QTNF9	LEP	ENSLACP00000014983	ENSLACP00000011398	C1q domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.631
CLTC	AP2A1	ENSLACP00000011035	ENSLACP00000019999	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Alpha_adaptinC2 domain-containing protein.	0.918
CLTC	INPP5K	ENSLACP00000011035	ENSLACP00000008065	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Inositol polyphosphate-5-phosphatase K.	0.403
CLTCL1	AP2A1	ENSLACP00000010273	ENSLACP00000019999	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Alpha_adaptinC2 domain-containing protein.	0.918
CLTCL1	INPP5K	ENSLACP00000010273	ENSLACP00000008065	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Inositol polyphosphate-5-phosphatase K.	0.403
DDB1	KAT2B	ENSLACP00000020033	ENSLACP00000007242	Damage specific DNA binding protein 1.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.439
DDB1	LOC102352539	ENSLACP00000020033	ENSLACP00000009233	Damage specific DNA binding protein 1.	Uncharacterized protein.	0.523
DDB1	SIRT1	ENSLACP00000020033	ENSLACP00000009079	Damage specific DNA binding protein 1.	Sirtuin 1.	0.411
DDB1	SIRT7	ENSLACP00000020033	ENSLACP00000010190	Damage specific DNA binding protein 1.	Sirtuin 7.	0.558
DDB1	USP7	ENSLACP00000020033	ENSLACP00000004236	Damage specific DNA binding protein 1.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.581
DGKQ	INPP5K	ENSLACP00000004252	ENSLACP00000008065	Diacylglycerol kinase.	Inositol polyphosphate-5-phosphatase K.	0.429
H2ZZS8_LATCH	H3A0C4_LATCH	ENSLACP00000002899	ENSLACP00000003095	Uncharacterized protein.	Uncharacterized protein.	0.486