(69 nodes) Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	TFAP4	Transcription factor AP-4. (350 aa)
	H2ZSP9_LATCH	Uncharacterized protein. (997 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1124 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1555 aa)
	H2ZX20_LATCH	Uncharacterized protein. (1016 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (539 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (433 aa)
	LOC102350164	Uncharacterized protein. (364 aa)
	LOC102348725	Uncharacterized protein. (641 aa)
	H3A2R2_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	H3A526_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
	LOC102345518	Death-associated protein. (104 aa)
	H3A7T5_LATCH	Uncharacterized protein. (999 aa)
	LOC102363280	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (329 aa)
	FAS	Uncharacterized protein. (330 aa)
	LOC102351334	Scinderin like a. (721 aa)
	GRAMD4	GRAM domain containing 4. (575 aa)
	PDCD2	Programmed cell death 2. (366 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	BAX	Uncharacterized protein. (223 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	SOX7	SRY-box transcription factor 7. (369 aa)
	SIRT1	Sirtuin 1. (729 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
	BOK	BCL2 family apoptosis regulator BOK. (111 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	H3ALU7_LATCH	NACHT domain-containing protein. (877 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (226 aa)
	BAD	Uncharacterized protein. (175 aa)
	H3APB7_LATCH	Mitochondrial E3 ubiquitin protein ligase 1a. (243 aa)
	H3APC7_LATCH	NACHT domain-containing protein. (686 aa)
	H3AQ35_LATCH	NACHT domain-containing protein. (880 aa)
	LOC102359041	Zgc:153993. (208 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	HTRA2	HtrA serine peptidase 2. (525 aa)
	IFT57	Intraflagellar transport 57. (428 aa)
	PDCD5	Programmed cell death 5. (128 aa)
	NLRC4	NLR family CARD domain containing 4. (1032 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1202 aa)
	LOC102359057	Uncharacterized protein. (103 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	ARL6IP5	PRA1 family protein. (196 aa)
	H3B5B6_LATCH	NACHT domain-containing protein. (692 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	LOC102359774	Uncharacterized protein. (218 aa)
	FASLG	Fas ligand. (261 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	MYC	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (412 aa)
	CCN1	Cellular communication network factor 1. (368 aa)
	LAPTM5	Lysosomal protein transmembrane 5. (268 aa)
	LOC102367479	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (992 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1039 aa)
	DIABLO	Diablo, IAP-binding mitochondrial protein b. (257 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (457 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (403 aa)
	HIP1	Huntingtin interacting protein 1. (1004 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1170 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (958 aa)
	M3XHJ5_LATCH	Uncharacterized protein. (158 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (143 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	APAF1	ENSLACP00000001333	ENSLACP00000014568	Apoptosis inducing factor mitochondria associated 1.	Apoptotic peptidase activating factor 1.	0.551
AIFM1	BAX	ENSLACP00000001333	ENSLACP00000007049	Apoptosis inducing factor mitochondria associated 1.	Uncharacterized protein.	0.922
AIFM1	CASP9	ENSLACP00000001333	ENSLACP00000020786	Apoptosis inducing factor mitochondria associated 1.	Caspase 9; Belongs to the peptidase C14A family.	0.587
AIFM1	DIABLO	ENSLACP00000001333	ENSLACP00000020692	Apoptosis inducing factor mitochondria associated 1.	Diablo, IAP-binding mitochondrial protein b.	0.578
AIFM1	LOC102359041	ENSLACP00000001333	ENSLACP00000012675	Apoptosis inducing factor mitochondria associated 1.	Zgc:153993.	0.926
AIFM1	LOC102363280	ENSLACP00000001333	ENSLACP00000005807	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.602
APAF1	AIFM1	ENSLACP00000014568	ENSLACP00000001333	Apoptotic peptidase activating factor 1.	Apoptosis inducing factor mitochondria associated 1.	0.551
APAF1	BAK1	ENSLACP00000014568	ENSLACP00000018296	Apoptotic peptidase activating factor 1.	BCL2 antagonist/killer 1.	0.670
APAF1	BAX	ENSLACP00000014568	ENSLACP00000007049	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.800
APAF1	BOK	ENSLACP00000014568	ENSLACP00000009914	Apoptotic peptidase activating factor 1.	BCL2 family apoptosis regulator BOK.	0.670
APAF1	CASP10	ENSLACP00000014568	ENSLACP00000002069	Apoptotic peptidase activating factor 1.	Caspase 10; Belongs to the peptidase C14A family.	0.875
APAF1	CASP2	ENSLACP00000014568	ENSLACP00000002990	Apoptotic peptidase activating factor 1.	Caspase 2; Belongs to the peptidase C14A family.	0.904
APAF1	CASP9	ENSLACP00000014568	ENSLACP00000020786	Apoptotic peptidase activating factor 1.	Caspase 9; Belongs to the peptidase C14A family.	0.995
APAF1	CRADD	ENSLACP00000014568	ENSLACP00000023466	Apoptotic peptidase activating factor 1.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.418
APAF1	DIABLO	ENSLACP00000014568	ENSLACP00000020692	Apoptotic peptidase activating factor 1.	Diablo, IAP-binding mitochondrial protein b.	0.990
APAF1	FASLG	ENSLACP00000014568	ENSLACP00000017423	Apoptotic peptidase activating factor 1.	Fas ligand.	0.626
APAF1	H3A2R2_LATCH	ENSLACP00000014568	ENSLACP00000003933	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.838
APAF1	H3A526_LATCH	ENSLACP00000014568	ENSLACP00000004747	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.838
APAF1	HTRA2	ENSLACP00000014568	ENSLACP00000013119	Apoptotic peptidase activating factor 1.	HtrA serine peptidase 2.	0.483
APAF1	LOC102359041	ENSLACP00000014568	ENSLACP00000012675	Apoptotic peptidase activating factor 1.	Zgc:153993.	0.670