(31 nodes) CD4-positive, alpha-beta T cell differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RC3H2	RING-type domain-containing protein. (352 aa)
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	GATA3	GATA binding protein 3. (447 aa)
	ARMC5	Armadillo repeat containing 5. (811 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	LOC102362196	Ig-like domain-containing protein. (206 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	IL6	Uncharacterized protein. (149 aa)
	IL18R1	TIR domain-containing protein. (153 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	HLX	H2.0 like homeobox. (384 aa)
	TOX	Thymocyte selection associated high mobility group box. (392 aa)
	PAX1	Paired box 1. (362 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	NKX2-3	NK2 homeobox 3. (334 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	SEMA4A	Sema domain-containing protein; Belongs to the semaphorin family. (758 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	RORA	RAR related orphan receptor A. (468 aa)
	RORC	RAR related orphan receptor C. (502 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (119 aa)
	H3BH49_LATCH	Ig-like domain-containing protein. (195 aa)
	H3BI75_LATCH	Uncharacterized protein. (110 aa)
	IL6R	Interleukin 6 receptor. (469 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	GATA3	ENSLACP00000020255	ENSLACP00000003446	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.480
BATF	RORA	ENSLACP00000020255	ENSLACP00000019843	Basic leucine zipper ATF-like transcription factor.	RAR related orphan receptor A.	0.530
BATF	STAT3	ENSLACP00000020255	ENSLACP00000013656	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.532
BRAF	STAT3	ENSLACP00000012774	ENSLACP00000013656	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.552
GATA3	BATF	ENSLACP00000003446	ENSLACP00000020255	GATA binding protein 3.	Basic leucine zipper ATF-like transcription factor.	0.480
GATA3	RORC	ENSLACP00000003446	ENSLACP00000020228	GATA binding protein 3.	RAR related orphan receptor C.	0.471
GATA3	STAT3	ENSLACP00000003446	ENSLACP00000013656	GATA binding protein 3.	Signal transducer and activator of transcription.	0.595
GATA3	TBX21	ENSLACP00000003446	ENSLACP00000019310	GATA binding protein 3.	T-box transcription factor 21.	0.735
H3B8U3_LATCH	MTOR	ENSLACP00000018314	ENSLACP00000018843	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.944
H3B8U3_LATCH	STAT3	ENSLACP00000018314	ENSLACP00000013656	Serine/threonine-protein kinase TOR.	Signal transducer and activator of transcription.	0.566
H3BI75_LATCH	RC3H1	ENSLACP00000021596	ENSLACP00000018376	Uncharacterized protein.	Ring finger and CCCH-type domains 1.	0.510
HLX	TBX21	ENSLACP00000010162	ENSLACP00000019310	H2.0 like homeobox.	T-box transcription factor 21.	0.559
IL6	IL6R	ENSLACP00000009318	ENSLACP00000022612	Uncharacterized protein.	Interleukin 6 receptor.	0.999
IL6	LOC102362196	ENSLACP00000009318	ENSLACP00000006243	Uncharacterized protein.	Ig-like domain-containing protein.	0.452
IL6	STAT3	ENSLACP00000009318	ENSLACP00000013656	Uncharacterized protein.	Signal transducer and activator of transcription.	0.933
IL6	TBX21	ENSLACP00000009318	ENSLACP00000019310	Uncharacterized protein.	T-box transcription factor 21.	0.471
IL6R	IL6	ENSLACP00000022612	ENSLACP00000009318	Interleukin 6 receptor.	Uncharacterized protein.	0.999
IL6R	STAT3	ENSLACP00000022612	ENSLACP00000013656	Interleukin 6 receptor.	Signal transducer and activator of transcription.	0.814
LOC102362196	IL6	ENSLACP00000006243	ENSLACP00000009318	Ig-like domain-containing protein.	Uncharacterized protein.	0.452
MTOR	H3B8U3_LATCH	ENSLACP00000018843	ENSLACP00000018314	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.944