(37 nodes) Negative regulation of MAP kinase activity network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (519 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (546 aa)
	LOC102354291	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
	PTPN6	Protein tyrosine phosphatase non-receptor type 6. (338 aa)
	SMPD1	Sphingomyelin phosphodiesterase 1. (396 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (439 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	GBA	Glucosylceramidase. (517 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	TMEM130	Transmembrane protein 130. (417 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	PAQR3	Uncharacterized protein. (175 aa)
	DUSP19	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (213 aa)
	AIDA	Axin interactor, dorsalization associated. (304 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (320 aa)
	LOC102367007	Uncharacterized protein. (335 aa)
	SORL1	Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (282 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (296 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	SH2B3	SH2B adaptor protein 3. (583 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	LOC102366507	Uncharacterized protein. (316 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (320 aa)
	DUSP10	Dual specificity phosphatase 10. (481 aa)
	LOC102362769	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	NF1	Neurofibromin 1. (2814 aa)
	HIPK3	Homeodomain interacting protein kinase 3. (1204 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	AGT	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	LOC102366507	ENSLACP00000000452	ENSLACP00000016933	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.418
ADIPOQ	PAQR3	ENSLACP00000000452	ENSLACP00000008121	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.626
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
CAV1	LOC102354291	ENSLACP00000014173	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.564
CAV3	LOC102354291	ENSLACP00000020888	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.572
CAV3	LYN	ENSLACP00000020888	ENSLACP00000006462	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.501
DUSP19	LOC102366507	ENSLACP00000008876	ENSLACP00000016933	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.520
DUSP19	PAQR3	ENSLACP00000008876	ENSLACP00000008121	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.520
GBA	SMPD1	ENSLACP00000006894	ENSLACP00000003877	Glucosylceramidase.	Sphingomyelin phosphodiesterase 1.	0.555
LOC102346019	ADIPOQ	ENSLACP00000019134	ENSLACP00000000452	C1q domain-containing protein.	Adiponectin, C1Q and collagen domain containing.	0.904
LOC102346019	LOC102366507	ENSLACP00000019134	ENSLACP00000016933	C1q domain-containing protein.	Uncharacterized protein.	0.418
LOC102346019	PAQR3	ENSLACP00000019134	ENSLACP00000008121	C1q domain-containing protein.	Uncharacterized protein.	0.626
LOC102354291	CAV1	ENSLACP00000002046	ENSLACP00000014173	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.564
LOC102354291	CAV3	ENSLACP00000002046	ENSLACP00000020888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.572
LOC102366507	ADIPOQ	ENSLACP00000016933	ENSLACP00000000452	Uncharacterized protein.	Adiponectin, C1Q and collagen domain containing.	0.418
LOC102366507	DUSP19	ENSLACP00000016933	ENSLACP00000008876	Uncharacterized protein.	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.520
LOC102366507	LOC102346019	ENSLACP00000016933	ENSLACP00000019134	Uncharacterized protein.	C1q domain-containing protein.	0.418
LYN	CAV3	ENSLACP00000006462	ENSLACP00000020888	Tyrosine-protein kinase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.501