(27 nodes) Protein kinase B signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3B9C8_LATCH	Uncharacterized protein. (1065 aa)
	TSC2	TSC complex subunit 2. (1836 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (657 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	ILK	Integrin linked kinase. (417 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	LOC102361574	Non-specific serine/threonine protein kinase. (340 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	LINGO1	Leucine rich repeat and Ig domain containing 1. (617 aa)
	FLCN	Folliculin. (576 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (897 aa)
	CD28	Ig-like domain-containing protein. (202 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	RPS6KB1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (443 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	GAS6	Uncharacterized protein. (681 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	SETX	Senataxin. (2165 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	C1QTNF12	C1q and TNF related 12. (265 aa)
	ADTRP	Uncharacterized protein. (229 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	GAS6	ENSLACP00000020423	ENSLACP00000016134	AXL receptor tyrosine kinase.	Uncharacterized protein.	0.704
CD28	CD40	ENSLACP00000010862	ENSLACP00000004148	Ig-like domain-containing protein.	TNFR-Cys domain-containing protein.	0.699
CD40	CD28	ENSLACP00000004148	ENSLACP00000010862	TNFR-Cys domain-containing protein.	Ig-like domain-containing protein.	0.699
CD40	H2ZS97_LATCH	ENSLACP00000004148	ENSLACP00000000268	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein.	0.481
CD40	H3AEV1_LATCH	ENSLACP00000004148	ENSLACP00000008172	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein.	0.481
CD40	TNFSF11	ENSLACP00000004148	ENSLACP00000009224	TNFR-Cys domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.845
EPHA2	LOC102351332	ENSLACP00000013291	ENSLACP00000013502	Uncharacterized protein.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.428
EPHA2	PIK3CA	ENSLACP00000013291	ENSLACP00000017606	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.428
FLCN	TSC2	ENSLACP00000010737	ENSLACP00000000293	Folliculin.	TSC complex subunit 2.	0.552
GAS6	AXL	ENSLACP00000016134	ENSLACP00000020423	Uncharacterized protein.	AXL receptor tyrosine kinase.	0.704
GAS6	MERTK	ENSLACP00000016134	ENSLACP00000010851	Uncharacterized protein.	MER proto-oncogene, tyrosine kinase.	0.852
H2ZS97_LATCH	CD40	ENSLACP00000000268	ENSLACP00000004148	TNF_2 domain-containing protein.	TNFR-Cys domain-containing protein.	0.481
H3AEV1_LATCH	CD40	ENSLACP00000008172	ENSLACP00000004148	TNF_2 domain-containing protein.	TNFR-Cys domain-containing protein.	0.481
H3AEV1_LATCH	TNFSF11	ENSLACP00000008172	ENSLACP00000009224	TNF_2 domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.448
KDR	LOC102351332	ENSLACP00000011126	ENSLACP00000013502	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.485
KDR	PIK3CA	ENSLACP00000011126	ENSLACP00000017606	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.965
LOC102351332	EPHA2	ENSLACP00000013502	ENSLACP00000013291	Zgc:158659; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.428
LOC102351332	KDR	ENSLACP00000013502	ENSLACP00000011126	Zgc:158659; Belongs to the PI3/PI4-kinase family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.485
LOC102361574	TSC2	ENSLACP00000008302	ENSLACP00000000293	Non-specific serine/threonine protein kinase.	TSC complex subunit 2.	0.755
LTA	SMPD3	ENSLACP00000007765	ENSLACP00000001384	Lymphotoxin alpha.	Sphingomyelin phosphodiesterase 3.	0.530