(24 nodes) Main axon network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C9orf72	C9orf72-SMCR8 complex subunit. (482 aa)
	H3A5Z5_LATCH	Hyaluronan and proteoglycan link protein 2. (306 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (221 aa)
	MAG	Myelin associated glycoprotein. (633 aa)
	ERMN	Uncharacterized protein. (114 aa)
	H3AFZ1_LATCH	Peptidase S72 domain-containing protein. (633 aa)
	MAP2	Microtubule-associated protein. (1361 aa)
	KCNAB2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (400 aa)
	MYOC	Myocilin. (272 aa)
	UCN	Urocortin. (167 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1092 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	SLC1A2	Amino acid transporter. (566 aa)
	H3B035_LATCH	Uncharacterized protein. (111 aa)
	CNTN2	Contactin 2. (1026 aa)
	NAV1	AAA domain-containing protein. (1482 aa)
	DAG1	Dystroglycan 1. (900 aa)
	LOC102358762	Amino acid transporter. (538 aa)
	PARD3	Par-3 family cell polarity regulator. (1214 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	DAGLA	Uncharacterized protein. (147 aa)
	SCN8A	Sodium voltage-gated channel alpha subunit 8. (1587 aa)
	MBP	Myelin basic protein. (133 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (465 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN5	PARD3	ENSLACP00000017353	ENSLACP00000017073	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Par-3 family cell polarity regulator.	0.650
CRHBP	UCN	ENSLACP00000013293	ENSLACP00000011213	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urocortin.	0.891
ERMN	H3A5Z5_LATCH	ENSLACP00000007359	ENSLACP00000005066	Uncharacterized protein.	Hyaluronan and proteoglycan link protein 2.	0.832
ERMN	MBP	ENSLACP00000007359	ENSLACP00000022061	Uncharacterized protein.	Myelin basic protein.	0.783
H3A5Z5_LATCH	ERMN	ENSLACP00000005066	ENSLACP00000007359	Hyaluronan and proteoglycan link protein 2.	Uncharacterized protein.	0.832
H3B035_LATCH	SCN8A	ENSLACP00000015256	ENSLACP00000021496	Uncharacterized protein.	Sodium voltage-gated channel alpha subunit 8.	0.448
MAG	MBP	ENSLACP00000005612	ENSLACP00000022061	Myelin associated glycoprotein.	Myelin basic protein.	0.904
MAP2	MBP	ENSLACP00000008676	ENSLACP00000022061	Microtubule-associated protein.	Myelin basic protein.	0.475
MBP	ERMN	ENSLACP00000022061	ENSLACP00000007359	Myelin basic protein.	Uncharacterized protein.	0.783
MBP	MAG	ENSLACP00000022061	ENSLACP00000005612	Myelin basic protein.	Myelin associated glycoprotein.	0.904
MBP	MAP2	ENSLACP00000022061	ENSLACP00000008676	Myelin basic protein.	Microtubule-associated protein.	0.475
NAV1	SCN8A	ENSLACP00000015882	ENSLACP00000021496	AAA domain-containing protein.	Sodium voltage-gated channel alpha subunit 8.	0.448
PARD3	CLDN5	ENSLACP00000017073	ENSLACP00000017353	Par-3 family cell polarity regulator.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650
SCN1B	SCN8A	ENSLACP00000005402	ENSLACP00000021496	Sodium voltage-gated channel beta subunit 1.	Sodium voltage-gated channel alpha subunit 8.	0.941
SCN8A	H3B035_LATCH	ENSLACP00000021496	ENSLACP00000015256	Sodium voltage-gated channel alpha subunit 8.	Uncharacterized protein.	0.448
SCN8A	NAV1	ENSLACP00000021496	ENSLACP00000015882	Sodium voltage-gated channel alpha subunit 8.	AAA domain-containing protein.	0.448
SCN8A	SCN1B	ENSLACP00000021496	ENSLACP00000005402	Sodium voltage-gated channel alpha subunit 8.	Sodium voltage-gated channel beta subunit 1.	0.941
UCN	CRHBP	ENSLACP00000011213	ENSLACP00000013293	Urocortin.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.891