(44 nodes) Plasma membrane raft network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (471 aa)
	NEU2	Neuraminidase 2. (381 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	PLPP2	Phospholipid phosphatase 2. (285 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	BVES	Blood vessel epicardial substance. (636 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (469 aa)
	ADRA1A	Adrenoceptor alpha 1A. (459 aa)
	LOC102354291	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (624 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	LCP2	Lymphocyte cytosolic protein 2. (518 aa)
	CLN3	Battenin. (406 aa)
	PTCH1	Patched 1. (1287 aa)
	LIPE	Lipase E, hormone sensitive type. (734 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	NEU3	Neuraminidase 3. (339 aa)
	CAVIN2	Caveolae associated protein 2. (427 aa)
	EZR	Ezrin. (591 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (468 aa)
	CAVIN4	Caveolae associated protein 4. (366 aa)
	RANGRF	Uncharacterized protein. (203 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	H3AF01_LATCH	Uncharacterized protein. (658 aa)
	MLC1	Modulator of VRAC current 1. (378 aa)
	PLPP1	Phospholipid phosphatase 1. (283 aa)
	ASAH2	Neutral ceramidase. (768 aa)
	AKAP6	Uncharacterized protein. (901 aa)
	ADCY8	AC_N domain-containing protein. (266 aa)
	CAVIN1	Caveolae associated protein 1. (358 aa)
	STIM1	Stromal interaction molecule 1. (662 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (451 aa)
	ADTRP	Uncharacterized protein. (229 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (962 aa)
	LOC102356233	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (256 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	PACSIN2	Protein kinase C and casein kinase substrate in neurons 2. (330 aa)
	ADD2	Adducin 2. (742 aa)
	SMPD2	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase). (410 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	CAV1	ENSLACP00000011649	ENSLACP00000014173	AC_N domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.405
ADCYAP1R1	H3AEK5_LATCH	ENSLACP00000015179	ENSLACP00000008076	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.555
AKAP6	H3AF01_LATCH	ENSLACP00000010706	ENSLACP00000008222	Uncharacterized protein.	Uncharacterized protein.	0.924
ASAH2	SMPD2	ENSLACP00000010184	ENSLACP00000018570	Neutral ceramidase.	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase).	0.605
CAV1	ADCY8	ENSLACP00000014173	ENSLACP00000011649	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	AC_N domain-containing protein.	0.405
CAV1	CAV2	ENSLACP00000014173	ENSLACP00000014086	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.933
CAV1	CAVIN1	ENSLACP00000014173	ENSLACP00000012159	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1.	0.858
CAV1	CAVIN2	ENSLACP00000014173	ENSLACP00000006442	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 2.	0.687
CAV1	CD36	ENSLACP00000014173	ENSLACP00000007631	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	CD36 molecule; Belongs to the CD36 family.	0.491
CAV1	CTNNB1	ENSLACP00000014173	ENSLACP00000017209	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.595
CAV1	FLOT1	ENSLACP00000014173	ENSLACP00000012571	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.613
CAV1	FLOT2	ENSLACP00000014173	ENSLACP00000014570	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.502
CAV1	LOC102354291	ENSLACP00000014173	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.564
CAV2	CAV1	ENSLACP00000014086	ENSLACP00000014173	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.933
CAV2	CAV3	ENSLACP00000014086	ENSLACP00000020888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976
CAV2	CAVIN1	ENSLACP00000014086	ENSLACP00000012159	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1.	0.788
CAV2	CAVIN2	ENSLACP00000014086	ENSLACP00000006442	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 2.	0.458
CAV2	CTNNB1	ENSLACP00000014086	ENSLACP00000017209	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.425
CAV2	FLOT1	ENSLACP00000014086	ENSLACP00000012571	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.685
CAV2	FLOT2	ENSLACP00000014086	ENSLACP00000014570	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.522