(24 nodes) T cell selection network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	GATA3	GATA binding protein 3. (447 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	IL6	Uncharacterized protein. (149 aa)
	TOX	Thymocyte selection associated high mobility group box. (392 aa)
	THEMIS	Thymocyte selection associated. (564 aa)
	CD3E	CD3e molecule. (191 aa)
	IL6R	Interleukin 6 receptor. (469 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (119 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	CD74	CD74 molecule. (279 aa)
	H3B480_LATCH	Uncharacterized protein. (567 aa)
	SRF	Serum response factor. (520 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	SYK	Tyrosine-protein kinase. (616 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	H3B8U3_LATCH	ENSLACP00000015035	ENSLACP00000018314	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase TOR.	0.453
ATG5	MTOR	ENSLACP00000015035	ENSLACP00000018843	Autophagy protein 5; Involved in autophagic vesicle formation.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.453
BATF	GATA3	ENSLACP00000020255	ENSLACP00000003446	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.480
BATF	H3B480_LATCH	ENSLACP00000020255	ENSLACP00000016701	Basic leucine zipper ATF-like transcription factor.	Uncharacterized protein.	0.607
BATF	STAT3	ENSLACP00000020255	ENSLACP00000013656	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.532
BRAF	STAT3	ENSLACP00000012774	ENSLACP00000013656	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.552
CARD11	SYK	ENSLACP00000004229	ENSLACP00000012982	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.692
CARD11	ZAP70	ENSLACP00000004229	ENSLACP00000008633	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.600
CCR7	CD3E	ENSLACP00000015163	ENSLACP00000022973	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3e molecule.	0.510
CCR7	IL6	ENSLACP00000015163	ENSLACP00000009318	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.572
CCR7	PTPRC	ENSLACP00000015163	ENSLACP00000003518	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Protein tyrosine phosphatase receptor type C.	0.635
CCR7	TBX21	ENSLACP00000015163	ENSLACP00000019310	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	T-box transcription factor 21.	0.470
CCR7	ZAP70	ENSLACP00000015163	ENSLACP00000008633	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Tyrosine-protein kinase.	0.460
CD3E	CCR7	ENSLACP00000022973	ENSLACP00000015163	CD3e molecule.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.510
CD3E	GATA3	ENSLACP00000022973	ENSLACP00000003446	CD3e molecule.	GATA binding protein 3.	0.551
CD3E	IL6	ENSLACP00000022973	ENSLACP00000009318	CD3e molecule.	Uncharacterized protein.	0.440
CD3E	PTPRC	ENSLACP00000022973	ENSLACP00000003518	CD3e molecule.	Protein tyrosine phosphatase receptor type C.	0.856
CD3E	SYK	ENSLACP00000022973	ENSLACP00000012982	CD3e molecule.	Tyrosine-protein kinase.	0.974
CD3E	ZAP70	ENSLACP00000022973	ENSLACP00000008633	CD3e molecule.	Tyrosine-protein kinase.	0.979
CD74	PTPRC	ENSLACP00000018188	ENSLACP00000003518	CD74 molecule.	Protein tyrosine phosphatase receptor type C.	0.522