(123 nodes) Regulation of innate immune response network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3A104_LATCH	CCHC-type domain-containing protein. (381 aa)
	OTOP1	Otopetrin 1. (584 aa)
	H3A265_LATCH	Uncharacterized protein. (280 aa)
	H3A2J7_LATCH	CCHC-type domain-containing protein. (402 aa)
	STING1	Uncharacterized protein. (380 aa)
	H3A3Z8_LATCH	SERPIN domain-containing protein; Belongs to the serpin family. (332 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	H3A6Y4_LATCH	CCHC-type domain-containing protein. (473 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	TRIM62	B30.2/SPRY domain-containing protein. (312 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (601 aa)
	LAMP1	Lysosomal associated membrane protein 1. (412 aa)
	XRCC5	X-ray repair cross complementing 5. (606 aa)
	H3ACA4_LATCH	Ig-like domain-containing protein. (156 aa)
	MATR3	Uncharacterized protein. (918 aa)
	H3AEK3_LATCH	Reverse transcriptase domain-containing protein. (275 aa)
	AKIRIN2	Akirin 2. (185 aa)
	IFI35	NID domain-containing protein. (215 aa)
	H3AHH8_LATCH	Uncharacterized protein. (387 aa)
	HPX	Uncharacterized protein. (228 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	H3AJ92_LATCH	Poly [ADP-ribose] polymerase. (308 aa)
	FADD	Fas associated via death domain. (193 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	H3AL20_LATCH	Poly [ADP-ribose] polymerase. (197 aa)
	NLRC3	NLR family CARD domain containing 3. (1005 aa)
	H3ALC0_LATCH	Uncharacterized protein. (630 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (314 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (286 aa)
	H3AMW7_LATCH	Uncharacterized protein. (445 aa)
	CXorf21	Chromosome X open reading frame 21. (302 aa)
	TRAFD1	TRAF-type zinc finger domain containing 1. (586 aa)
	LOC102354087	SAM domain and HD domain 1. (617 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	XRCC6	X-ray repair cross complementing 6. (610 aa)
	LOC102367007	Uncharacterized protein. (335 aa)
	COCH	Cochlin. (547 aa)
	PSPC1	Paraspeckle component 1. (525 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (710 aa)
	GFER	Sulfhydryl oxidase. (193 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	DHX58	DExH-box helicase 58. (680 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (577 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	H3AUL4_LATCH	Ig-like domain-containing protein. (268 aa)
	MASP1	Mannan binding lectin serine peptidase 1. (745 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1819 aa)
	H3AVS7_LATCH	CCHC-type domain-containing protein. (336 aa)
	LOC102360619	Uncharacterized protein. (89 aa)
	H3AW55_LATCH	CCHC-type domain-containing protein. (307 aa)
	NLRC4	NLR family CARD domain containing 4. (1032 aa)
	H3AXB5_LATCH	Poly [ADP-ribose] polymerase. (804 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	DCST1	DC-STAMP domain containing 1. (696 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
	TBK1	TANK binding kinase 1. (675 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
	HAVCR2	Ig-like domain-containing protein. (267 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	SFPQ	Splicing factor proline and glutamine rich. (622 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (768 aa)
	N4BP1	NEDD4 binding protein 1. (806 aa)
	FCN3	Fibrinogen C-terminal domain-containing protein. (331 aa)
	H3B766_LATCH	Fibrinogen C-terminal domain-containing protein. (257 aa)
	DUSP10	Dual specificity phosphatase 10. (481 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (627 aa)
	POLR3D	RNA polymerase III subunit D. (397 aa)
	H2ZRL7_LATCH	Uncharacterized protein. (352 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (483 aa)
	H2ZS84_LATCH	CCHC-type domain-containing protein. (321 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	LOC102358678	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	NONO	Non-POU domain containing octamer binding. (418 aa)
	SUSD4	Sushi domain containing 4. (443 aa)
	H2ZUR6_LATCH	Poly [ADP-ribose] polymerase. (601 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (145 aa)
	H2ZVR1_LATCH	Uncharacterized protein. (167 aa)
	H2ZVX2_LATCH	Uncharacterized protein. (322 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (546 aa)
	M3XLP0_LATCH	Uncharacterized protein. (315 aa)
	M3XLK8_LATCH	Uncharacterized protein. (398 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1938 aa)
	M3XJL3_LATCH	HIN-200 domain-containing protein. (217 aa)
	M3XIR8_LATCH	CCHC-type domain-containing protein. (383 aa)
	SH2D1A	SH2 domain containing 1A. (124 aa)
	LOC102354416	Uncharacterized protein. (160 aa)
	LYAR	Ly1 antibody reactive. (403 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	ADAR	Adenosine deaminase RNA specific. (1150 aa)
	AIM2	HIN-200 domain-containing protein. (205 aa)
	CADM1	Uncharacterized protein. (321 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	SAMHD1	Uncharacterized protein. (621 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	NLRX1	NLR family member X1. (855 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	LOC102354684	Immunoresponsive gene 1, like. (506 aa)
	TKFC	Triokinase and FMN cyclase. (582 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (513 aa)
	NCF1	Neutrophil cytosolic factor 1. (416 aa)
	GRN	Granulin precursor. (751 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (529 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
	MASP2	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (557 aa)
	IRF3	Interferon regulatory factor 3. (481 aa)
	H3BAW7_LATCH	Uncharacterized protein. (190 aa)
	H2ZWA9_LATCH	Uncharacterized protein. (145 aa)
	PQBP1	Polyglutamine binding protein 1. (268 aa)
	H2ZX10_LATCH	Uncharacterized protein. (436 aa)
	LOC102367457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	FAM3A	Family with sequence similarity 3 member A. (227 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (269 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (595 aa)
	H2ZYV4_LATCH	CCHC-type domain-containing protein. (330 aa)
	H2ZZU3_LATCH	CCHC-type domain-containing protein. (400 aa)
	NMI	N-myc and STAT interactor. (372 aa)
	H3A0N5_LATCH	CCHC-type domain-containing protein. (296 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DHX58	ENSLACP00000021926	ENSLACP00000012725	Adenosine deaminase RNA specific.	DExH-box helicase 58.	0.429
ADAR	YTHDF2	ENSLACP00000021926	ENSLACP00000013039	Adenosine deaminase RNA specific.	YTH N6-methyladenosine RNA binding protein 2.	0.658
ADAR	ZNFX1	ENSLACP00000021926	ENSLACP00000023068	Adenosine deaminase RNA specific.	Zinc finger NFX1-type containing 1.	0.627
AIM2	IRF3	ENSLACP00000021844	ENSLACP00000019335	HIN-200 domain-containing protein.	Interferon regulatory factor 3.	0.433
AIM2	LOC102349920	ENSLACP00000021844	ENSLACP00000010067	HIN-200 domain-containing protein.	Uncharacterized protein.	0.948
AIM2	NLRC4	ENSLACP00000021844	ENSLACP00000014259	HIN-200 domain-containing protein.	NLR family CARD domain containing 4.	0.910
AIM2	STING1	ENSLACP00000021844	ENSLACP00000004185	HIN-200 domain-containing protein.	Uncharacterized protein.	0.403
AIM2	TLR9	ENSLACP00000021844	ENSLACP00000020965	HIN-200 domain-containing protein.	Toll-like receptor 9.	0.531
AKIRIN2	DHX58	ENSLACP00000008157	ENSLACP00000012725	Akirin 2.	DExH-box helicase 58.	0.427
APPL1	APPL2	ENSLACP00000012610	ENSLACP00000000307	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.997
APPL1	CASP6	ENSLACP00000012610	ENSLACP00000002246	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Caspase 6; Belongs to the peptidase C14A family.	0.686
APPL1	POLR3F	ENSLACP00000012610	ENSLACP00000010638	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	0.454
APPL2	APPL1	ENSLACP00000000307	ENSLACP00000012610	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.997
APPL2	CASP6	ENSLACP00000000307	ENSLACP00000002246	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Caspase 6; Belongs to the peptidase C14A family.	0.686
APPL2	POLR3F	ENSLACP00000000307	ENSLACP00000010638	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	0.453
ATG12	ATG5	ENSLACP00000001446	ENSLACP00000015035	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP6	ENSLACP00000001446	ENSLACP00000002246	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 6; Belongs to the peptidase C14A family.	0.420
ATG12	DHX58	ENSLACP00000001446	ENSLACP00000012725	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.423
ATG12	FADD	ENSLACP00000001446	ENSLACP00000009943	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Fas associated via death domain.	0.719
ATG12	LAMP1	ENSLACP00000001446	ENSLACP00000006760	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Lysosomal associated membrane protein 1.	0.551