(74 nodes) Positive regulation of innate immune response network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M3XLP0_LATCH	Uncharacterized protein. (315 aa)
	H2ZRL7_LATCH	Uncharacterized protein. (352 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (483 aa)
	H2ZS84_LATCH	CCHC-type domain-containing protein. (321 aa)
	LOC102358678	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	NONO	Non-POU domain containing octamer binding. (418 aa)
	H2ZVR1_LATCH	Uncharacterized protein. (167 aa)
	H2ZVX2_LATCH	Uncharacterized protein. (322 aa)
	H2ZWA9_LATCH	Uncharacterized protein. (145 aa)
	PQBP1	Polyglutamine binding protein 1. (268 aa)
	H2ZX10_LATCH	Uncharacterized protein. (436 aa)
	LOC102367457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (269 aa)
	H2ZYV4_LATCH	CCHC-type domain-containing protein. (330 aa)
	H2ZZU3_LATCH	CCHC-type domain-containing protein. (400 aa)
	NMI	N-myc and STAT interactor. (372 aa)
	H3A0N5_LATCH	CCHC-type domain-containing protein. (296 aa)
	H3A104_LATCH	CCHC-type domain-containing protein. (381 aa)
	H3A265_LATCH	Uncharacterized protein. (280 aa)
	H3A2J7_LATCH	CCHC-type domain-containing protein. (402 aa)
	STING1	Uncharacterized protein. (380 aa)
	H3A6Y4_LATCH	CCHC-type domain-containing protein. (473 aa)
	TRIM62	B30.2/SPRY domain-containing protein. (312 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (601 aa)
	LAMP1	Lysosomal associated membrane protein 1. (412 aa)
	XRCC5	X-ray repair cross complementing 5. (606 aa)
	H3ACA4_LATCH	Ig-like domain-containing protein. (156 aa)
	MATR3	Uncharacterized protein. (918 aa)
	H3AEK3_LATCH	Reverse transcriptase domain-containing protein. (275 aa)
	AKIRIN2	Akirin 2. (185 aa)
	IFI35	NID domain-containing protein. (215 aa)
	H3AHH8_LATCH	Uncharacterized protein. (387 aa)
	HPX	Uncharacterized protein. (228 aa)
	FADD	Fas associated via death domain. (193 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (314 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	CXorf21	Chromosome X open reading frame 21. (302 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	XRCC6	X-ray repair cross complementing 6. (610 aa)
	COCH	Cochlin. (547 aa)
	PSPC1	Paraspeckle component 1. (525 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (710 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	H3AUL4_LATCH	Ig-like domain-containing protein. (268 aa)
	MASP1	Mannan binding lectin serine peptidase 1. (745 aa)
	H3AVS7_LATCH	CCHC-type domain-containing protein. (336 aa)
	H3AW55_LATCH	CCHC-type domain-containing protein. (307 aa)
	NLRC4	NLR family CARD domain containing 4. (1032 aa)
	H3AXB5_LATCH	Poly [ADP-ribose] polymerase. (804 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	TBK1	TANK binding kinase 1. (675 aa)
	HAVCR2	Ig-like domain-containing protein. (267 aa)
	SFPQ	Splicing factor proline and glutamine rich. (622 aa)
	FCN3	Fibrinogen C-terminal domain-containing protein. (331 aa)
	H3B766_LATCH	Fibrinogen C-terminal domain-containing protein. (257 aa)
	POLR3D	RNA polymerase III subunit D. (397 aa)
	IRF3	Interferon regulatory factor 3. (481 aa)
	MASP2	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (557 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (529 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (513 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	CADM1	Uncharacterized protein. (321 aa)
	AIM2	HIN-200 domain-containing protein. (205 aa)
	SH2D1A	SH2 domain containing 1A. (124 aa)
	M3XIR8_LATCH	CCHC-type domain-containing protein. (383 aa)
	M3XJL3_LATCH	HIN-200 domain-containing protein. (217 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1938 aa)
	M3XLK8_LATCH	Uncharacterized protein. (398 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	IRF3	ENSLACP00000021844	ENSLACP00000019335	HIN-200 domain-containing protein.	Interferon regulatory factor 3.	0.433
AIM2	LOC102349920	ENSLACP00000021844	ENSLACP00000010067	HIN-200 domain-containing protein.	Uncharacterized protein.	0.948
AIM2	NLRC4	ENSLACP00000021844	ENSLACP00000014259	HIN-200 domain-containing protein.	NLR family CARD domain containing 4.	0.910
AIM2	STING1	ENSLACP00000021844	ENSLACP00000004185	HIN-200 domain-containing protein.	Uncharacterized protein.	0.403
AIM2	TLR9	ENSLACP00000021844	ENSLACP00000020965	HIN-200 domain-containing protein.	Toll-like receptor 9.	0.531
CADM1	H2ZX10_LATCH	ENSLACP00000021258	ENSLACP00000001931	Uncharacterized protein.	Uncharacterized protein.	0.512
CARD9	H2ZWA9_LATCH	ENSLACP00000020146	ENSLACP00000001680	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.617
CARD9	SYK	ENSLACP00000020146	ENSLACP00000012982	Caspase recruitment domain family member 9.	Tyrosine-protein kinase.	0.970
CARD9	TRIM62	ENSLACP00000020146	ENSLACP00000006146	Caspase recruitment domain family member 9.	B30.2/SPRY domain-containing protein.	0.617
CASP6	FADD	ENSLACP00000002246	ENSLACP00000009943	Caspase 6; Belongs to the peptidase C14A family.	Fas associated via death domain.	0.594
CASP6	H3AXB5_LATCH	ENSLACP00000002246	ENSLACP00000014286	Caspase 6; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.493
FADD	CASP6	ENSLACP00000009943	ENSLACP00000002246	Fas associated via death domain.	Caspase 6; Belongs to the peptidase C14A family.	0.594
FADD	IRF3	ENSLACP00000009943	ENSLACP00000019335	Fas associated via death domain.	Interferon regulatory factor 3.	0.434
FADD	SYK	ENSLACP00000009943	ENSLACP00000012982	Fas associated via death domain.	Tyrosine-protein kinase.	0.661
FCN3	MASP1	ENSLACP00000017658	ENSLACP00000013462	Fibrinogen C-terminal domain-containing protein.	Mannan binding lectin serine peptidase 1.	0.850
FCN3	MASP2	ENSLACP00000017658	ENSLACP00000019349	Fibrinogen C-terminal domain-containing protein.	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family.	0.824
H2ZWA9_LATCH	CARD9	ENSLACP00000001680	ENSLACP00000020146	Uncharacterized protein.	Caspase recruitment domain family member 9.	0.617
H2ZWA9_LATCH	TRIM62	ENSLACP00000001680	ENSLACP00000006146	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.899
H2ZX10_LATCH	CADM1	ENSLACP00000001931	ENSLACP00000021258	Uncharacterized protein.	Uncharacterized protein.	0.512
H3AM65_LATCH	IFI35	ENSLACP00000010736	ENSLACP00000009062	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NID domain-containing protein.	0.908