(65 nodes) Fat cell differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX8	SRY-box transcription factor 8. (477 aa)
	LOC102358678	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	FBXO9	F-box protein 9. (433 aa)
	ZNF516	Zinc finger protein 516. (1157 aa)
	RNASEL	Uncharacterized protein. (698 aa)
	BBS12	Bardet-Biedl syndrome 12. (709 aa)
	CLIP3	CAP-Gly domain containing linker protein 3. (536 aa)
	LRG1	LRRCT domain-containing protein. (337 aa)
	LOC102367457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	TRIM32	Tripartite motif containing 32. (647 aa)
	BBS7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	ADRB3	Adrenoceptor beta 3a. (407 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (855 aa)
	ADRB2	Adrenoceptor beta 2. (432 aa)
	STEAP4	STEAP4 metalloreductase. (459 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (592 aa)
	METRNL	Meteorin like, glial cell differentiation regulator. (288 aa)
	H3A6Z7_LATCH	Bardet-Biedl syndrome 1. (596 aa)
	FAM120B	Family with sequence similarity 120B. (834 aa)
	NIPBL	Nipped-B protein. (2707 aa)
	SMAD6	Mothers against decapentaplegic homolog. (485 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	BBS9	Bardet-Biedl syndrome 9. (707 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	ATF5	Activating transcription factor 5. (340 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	ADRB1	Adrenoceptor beta 1. (394 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (518 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (599 aa)
	LRRC8C	Leucine rich repeat containing 8 VRAC subunit C. (805 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	CTBP2	C-terminal binding protein 2. (1002 aa)
	GLIS1	GLIS family zinc finger 1. (704 aa)
	RETREG1	Reticulophagy regulator 1. (458 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
	CNTN2	Contactin 2. (1026 aa)
	PSMB8	Proteasome subunit beta. (271 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (724 aa)
	LAMA4	Laminin subunit alpha 4. (1721 aa)
	CEBPD	CCAAT/enhancer-binding protein. (288 aa)
	INHBB	Inhibin subunit beta B. (393 aa)
	H3BB14_LATCH	Uncharacterized protein. (123 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	DIO2	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (130 aa)
	LOC102357156	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
	BSCL2	BSCL2 lipid droplet biogenesis associated, seipin. (290 aa)
	NOC3L	Nucleolar complex protein 3 homolog. (795 aa)
	TMEM120B	Transmembrane protein 120B. (335 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (475 aa)
	TMEM120A	Transmembrane protein 120A. (345 aa)
	LAMB3	Laminin subunit beta 3. (1160 aa)
	SDF4	Stromal cell derived factor 4. (357 aa)
	PRDM16-2	Si:ch211-263k4.2. (114 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	PRDM16	PR/SET domain 16. (1135 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (580 aa)
	TTC8	Tetratricopeptide repeat domain 8. (534 aa)
	DHRS7B	Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	ADRB3	ENSLACP00000000452	ENSLACP00000002909	Adiponectin, C1Q and collagen domain containing.	Adrenoceptor beta 3a.	0.445
ADIPOQ	CEBPB	ENSLACP00000000452	ENSLACP00000002325	Adiponectin, C1Q and collagen domain containing.	CCAAT/enhancer-binding protein.	0.632
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	PPARG	ENSLACP00000000452	ENSLACP00000010456	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.829
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
ADRB1	ADRB3	ENSLACP00000011780	ENSLACP00000002909	Adrenoceptor beta 1.	Adrenoceptor beta 3a.	0.668
ADRB2	ADRB3	ENSLACP00000003966	ENSLACP00000002909	Adrenoceptor beta 2.	Adrenoceptor beta 3a.	0.680
ADRB3	ADIPOQ	ENSLACP00000002909	ENSLACP00000000452	Adrenoceptor beta 3a.	Adiponectin, C1Q and collagen domain containing.	0.445
ADRB3	ADRB1	ENSLACP00000002909	ENSLACP00000011780	Adrenoceptor beta 3a.	Adrenoceptor beta 1.	0.668
ADRB3	ADRB2	ENSLACP00000002909	ENSLACP00000003966	Adrenoceptor beta 3a.	Adrenoceptor beta 2.	0.680
ALDH6A1	TTC8	ENSLACP00000020957	ENSLACP00000022744	Aldehyde dehydrogenase 6 family member A1.	Tetratricopeptide repeat domain 8.	0.887
ATF5	CEBPB	ENSLACP00000009869	ENSLACP00000002325	Activating transcription factor 5.	CCAAT/enhancer-binding protein.	0.510
ATF5	CEBPD	ENSLACP00000009869	ENSLACP00000017118	Activating transcription factor 5.	CCAAT/enhancer-binding protein.	0.502
BBS12	BBS2	ENSLACP00000001386	ENSLACP00000017026	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 2 protein homolog.	0.717
BBS12	BBS4	ENSLACP00000001386	ENSLACP00000002102	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 4.	0.633
BBS12	BBS7	ENSLACP00000001386	ENSLACP00000002676	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.800
BBS12	BBS9	ENSLACP00000001386	ENSLACP00000007483	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 9.	0.717
BBS12	H3A6Z7_LATCH	ENSLACP00000001386	ENSLACP00000005418	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 1.	0.648
BBS12	MKKS	ENSLACP00000001386	ENSLACP00000006659	Bardet-Biedl syndrome 12.	McKusick-Kaufman syndrome.	0.811
BBS12	TRIM32	ENSLACP00000001386	ENSLACP00000002454	Bardet-Biedl syndrome 12.	Tripartite motif containing 32.	0.493