(87 nodes) Regulation of T cell differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLI3	GLI family zinc finger 3. (1456 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	IL18	Uncharacterized protein. (200 aa)
	H3BI75_LATCH	Uncharacterized protein. (110 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1195 aa)
	MDK	Midkine. (141 aa)
	H3BH49_LATCH	Ig-like domain-containing protein. (195 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (420 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	FANCD2	FA complementation group D2. (1462 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	H3BCG1_LATCH	SET domain-containing protein. (714 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	TCF7	Transcription factor 7. (343 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (706 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	CD74	CD74 molecule. (279 aa)
	DUSP10	Dual specificity phosphatase 10. (481 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	H3B782_LATCH	Si:ch211-157b11.8. (221 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
	H3B5B6_LATCH	NACHT domain-containing protein. (692 aa)
	SLC46A2	Solute carrier family 46 member 2. (461 aa)
	TESPA1	KRAP_IP3R_bind domain-containing protein. (96 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1076 aa)
	FANCA	FA complementation group A. (1436 aa)
	TMEM131L	Transmembrane 131 like. (1522 aa)
	PRELID1	PRELI domain containing 1. (216 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	H3AT06_LATCH	Uncharacterized protein. (88 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	RHOH	Ras homolog family member H. (189 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (649 aa)
	H3ASL3_LATCH	Si:ch211-203k16.3. (394 aa)
	H3ASJ2_LATCH	ANK_REP_REGION domain-containing protein. (303 aa)
	H3ASA2_LATCH	Ig-like domain-containing protein. (290 aa)
	LOC102367007	Uncharacterized protein. (335 aa)
	SH3RF1	SH3 domain containing ring finger 1. (745 aa)
	H3AQ35_LATCH	NACHT domain-containing protein. (880 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	H3APC7_LATCH	NACHT domain-containing protein. (686 aa)
	BAD	Uncharacterized protein. (175 aa)
	SOX13	Uncharacterized protein. (195 aa)
	H3ALU7_LATCH	NACHT domain-containing protein. (877 aa)
	TOX	Thymocyte selection associated high mobility group box. (392 aa)
	LOC102346566	Annexin. (343 aa)
	HLX	H2.0 like homeobox. (384 aa)
	CTLA4	IG domain-containing protein. (186 aa)
	H3AJR0_LATCH	SRY-box transcription factor 13. (427 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	LOC102351706	PRELI domain containing 1b. (213 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1241 aa)
	CBFB	Core-binding factor subunit beta. (189 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	H3ABW1_LATCH	ANK_REP_REGION domain-containing protein. (323 aa)
	DROSHA	Drosha ribonuclease III. (1347 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	LOC102362196	Ig-like domain-containing protein. (206 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	H3A7T5_LATCH	Uncharacterized protein. (999 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (112 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	FGL2	Fibrinogen like 2. (441 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	GATA3	GATA binding protein 3. (447 aa)
	LOC102348725	Uncharacterized protein. (641 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	SOCS5	Suppressor of cytokine signaling 5. (538 aa)
	H2ZX66_LATCH	Uncharacterized protein. (641 aa)
	H2ZX20_LATCH	Uncharacterized protein. (1016 aa)
	H2ZX10_LATCH	Uncharacterized protein. (436 aa)
	IRF1	Interferon regulatory factor. (264 aa)
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	RC3H2	RING-type domain-containing protein. (352 aa)
	H2ZSP9_LATCH	Uncharacterized protein. (997 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	CTLA4	ENSLACP00000012774	ENSLACP00000010132	B-Raf proto-oncogene, serine/threonine kinase.	IG domain-containing protein.	0.472
BRAF	SOS1	ENSLACP00000012774	ENSLACP00000004382	B-Raf proto-oncogene, serine/threonine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.617
CARD11	H3B0U4_LATCH	ENSLACP00000004229	ENSLACP00000015515	Caspase recruitment domain family member 11.	MALT paracaspase 2.	0.899
CARD11	LOC102348796	ENSLACP00000004229	ENSLACP00000023619	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.521
CARD11	LOC102353021	ENSLACP00000004229	ENSLACP00000018014	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.853
CARD11	MALT1	ENSLACP00000004229	ENSLACP00000004155	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.899
CARD11	RHOH	ENSLACP00000004229	ENSLACP00000012746	Caspase recruitment domain family member 11.	Ras homolog family member H.	0.512
CARD11	RIPK2	ENSLACP00000004229	ENSLACP00000004499	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.521
CARD11	SYK	ENSLACP00000004229	ENSLACP00000012982	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.692
CARD11	ZAP70	ENSLACP00000004229	ENSLACP00000008633	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.600
CBFB	GATA3	ENSLACP00000008364	ENSLACP00000003446	Core-binding factor subunit beta.	GATA binding protein 3.	0.711
CBFB	TGFB1	ENSLACP00000008364	ENSLACP00000020652	Core-binding factor subunit beta.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.465
CD74	DROSHA	ENSLACP00000018188	ENSLACP00000006694	CD74 molecule.	Drosha ribonuclease III.	0.598
CD74	H3B2C8_LATCH	ENSLACP00000018188	ENSLACP00000016049	CD74 molecule.	Uncharacterized protein.	0.465
CD74	PTPRC	ENSLACP00000018188	ENSLACP00000003518	CD74 molecule.	Protein tyrosine phosphatase receptor type C.	0.522
CTLA4	BRAF	ENSLACP00000010132	ENSLACP00000012774	IG domain-containing protein.	B-Raf proto-oncogene, serine/threonine kinase.	0.472
CTLA4	IL18	ENSLACP00000010132	ENSLACP00000021930	IG domain-containing protein.	Uncharacterized protein.	0.404
CTLA4	PTPRC	ENSLACP00000010132	ENSLACP00000003518	IG domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.452
CTLA4	ZAP70	ENSLACP00000010132	ENSLACP00000008633	IG domain-containing protein.	Tyrosine-protein kinase.	0.402
DROSHA	CD74	ENSLACP00000006694	ENSLACP00000018188	Drosha ribonuclease III.	CD74 molecule.	0.598