(54 nodes) Positive regulation of T cell differentiation network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	H2ZX20_LATCH	Uncharacterized protein. (1016 aa)
	H2ZX66_LATCH	Uncharacterized protein. (641 aa)
	SOCS5	Suppressor of cytokine signaling 5. (538 aa)
	H2ZSP9_LATCH	Uncharacterized protein. (997 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	LOC102348725	Uncharacterized protein. (641 aa)
	GATA3	GATA binding protein 3. (447 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	H3A7T5_LATCH	Uncharacterized protein. (999 aa)
	LOC102362196	Ig-like domain-containing protein. (206 aa)
	H3ABW1_LATCH	ANK_REP_REGION domain-containing protein. (323 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	CBFB	Core-binding factor subunit beta. (189 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	H3AJR0_LATCH	SRY-box transcription factor 13. (427 aa)
	HLX	H2.0 like homeobox. (384 aa)
	LOC102346566	Annexin. (343 aa)
	H3ALU7_LATCH	NACHT domain-containing protein. (877 aa)
	SOX13	Uncharacterized protein. (195 aa)
	BAD	Uncharacterized protein. (175 aa)
	H3APC7_LATCH	NACHT domain-containing protein. (686 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	H3AQ35_LATCH	NACHT domain-containing protein. (880 aa)
	LOC102367007	Uncharacterized protein. (335 aa)
	H3ASA2_LATCH	Ig-like domain-containing protein. (290 aa)
	H3ASJ2_LATCH	ANK_REP_REGION domain-containing protein. (303 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (649 aa)
	RHOH	Ras homolog family member H. (189 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	TESPA1	KRAP_IP3R_bind domain-containing protein. (96 aa)
	H3B5B6_LATCH	NACHT domain-containing protein. (692 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	DUSP10	Dual specificity phosphatase 10. (481 aa)
	CD74	CD74 molecule. (279 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (706 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (420 aa)
	H3BH49_LATCH	Ig-like domain-containing protein. (195 aa)
	MDK	Midkine. (141 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1195 aa)
	IL18	Uncharacterized protein. (200 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBFB	GATA3	ENSLACP00000008364	ENSLACP00000003446	Core-binding factor subunit beta.	GATA binding protein 3.	0.711
CBFB	TGFB1	ENSLACP00000008364	ENSLACP00000020652	Core-binding factor subunit beta.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.465
CD74	H3B2C8_LATCH	ENSLACP00000018188	ENSLACP00000016049	CD74 molecule.	Uncharacterized protein.	0.465
CD74	PTPRC	ENSLACP00000018188	ENSLACP00000003518	CD74 molecule.	Protein tyrosine phosphatase receptor type C.	0.522
GATA3	CBFB	ENSLACP00000003446	ENSLACP00000008364	GATA binding protein 3.	Core-binding factor subunit beta.	0.711
GATA3	MYB	ENSLACP00000003446	ENSLACP00000003141	GATA binding protein 3.	MYB proto-oncogene, transcription factor.	0.604
H2ZSX8_LATCH	SOCS5	ENSLACP00000000499	ENSLACP00000002955	Fibronectin type-III domain-containing protein.	Suppressor of cytokine signaling 5.	0.530
H3AGM7_LATCH	SOCS5	ENSLACP00000008798	ENSLACP00000002955	Fibronectin type-III domain-containing protein.	Suppressor of cytokine signaling 5.	0.530
H3AJR0_LATCH	LEF1	ENSLACP00000009881	ENSLACP00000005598	SRY-box transcription factor 13.	Lymphoid enhancer binding factor 1.	0.505
H3AJR0_LATCH	SOX13	ENSLACP00000009881	ENSLACP00000010728	SRY-box transcription factor 13.	Uncharacterized protein.	0.900
H3B0U4_LATCH	LOC102353021	ENSLACP00000015515	ENSLACP00000018014	MALT paracaspase 2.	Uncharacterized protein.	0.906
H3B0U4_LATCH	MALT1	ENSLACP00000015515	ENSLACP00000004155	MALT paracaspase 2.	MALT1 paracaspase.	0.902
H3B0U4_LATCH	SYK	ENSLACP00000015515	ENSLACP00000012982	MALT paracaspase 2.	Tyrosine-protein kinase.	0.469
H3B2C8_LATCH	CD74	ENSLACP00000016049	ENSLACP00000018188	Uncharacterized protein.	CD74 molecule.	0.465
LEF1	H3AJR0_LATCH	ENSLACP00000005598	ENSLACP00000009881	Lymphoid enhancer binding factor 1.	SRY-box transcription factor 13.	0.505
LEF1	MYB	ENSLACP00000005598	ENSLACP00000003141	Lymphoid enhancer binding factor 1.	MYB proto-oncogene, transcription factor.	0.410
LEF1	SOX13	ENSLACP00000005598	ENSLACP00000010728	Lymphoid enhancer binding factor 1.	Uncharacterized protein.	0.505
LOC102348796	RIPK2	ENSLACP00000023619	ENSLACP00000004499	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.900
LOC102353021	H3B0U4_LATCH	ENSLACP00000018014	ENSLACP00000015515	Uncharacterized protein.	MALT paracaspase 2.	0.906
LOC102353021	MALT1	ENSLACP00000018014	ENSLACP00000004155	Uncharacterized protein.	MALT1 paracaspase.	0.902