STRINGSTRING
WNT1 WNT1 WWTR1 WWTR1 ZFPM2 ZFPM2 MEDAG MEDAG ADIPOQ ADIPOQ HTR2A HTR2A JAG1 JAG1 BBS12 BBS12 H2ZW26_LATCH H2ZW26_LATCH LOC102346204 LOC102346204 H2ZX66_LATCH H2ZX66_LATCH CEBPB CEBPB ASXL2 ASXL2 STK4 STK4 ATAT1 ATAT1 GATA3 GATA3 ZNF385A ZNF385A NAPEPLD NAPEPLD YAP1 YAP1 DLK2 DLK2 WWTR1-2 WWTR1-2 KLF5 KLF5 ARNTL ARNTL METRNL METRNL VSTM2A VSTM2A LOC102358168 LOC102358168 ZBTB7C ZBTB7C TRIB3 TRIB3 SFRP2 SFRP2 TMEM64 TMEM64 E2F1 E2F1 GPER1 GPER1 SIRT6 SIRT6 SIRT1 SIRT1 PTGS2 PTGS2 PTPRQ PTPRQ H3AJR0_LATCH H3AJR0_LATCH MMP11 MMP11 PPARG PPARG RREB1 RREB1 SOX13 SOX13 FLCN FLCN LOC102350018 LOC102350018 NR1D1 NR1D1 LEP LEP TRIO TRIO LOC102367007 LOC102367007 WIF1 WIF1 LOC102360823 LOC102360823 AXIN1 AXIN1 TPH1 TPH1 SAV1 SAV1 ZFP36L2 ZFP36L2 H3AYC1_LATCH H3AYC1_LATCH LOC102356748 LOC102356748 TAF8 TAF8 CCDC85B CCDC85B ZADH2 ZADH2 H3B2C8_LATCH H3B2C8_LATCH FNDC3B FNDC3B ZBTB7B ZBTB7B LOC102359601 LOC102359601 FNDC5 FNDC5 SORT1 SORT1 CARM1 CARM1 H3B7I7_LATCH H3B7I7_LATCH NOCT NOCT CREB1 CREB1 DUSP10 DUSP10 LOC106701779 LOC106701779 LOC102351049 LOC102351049 LOC102346019 LOC102346019 AXIN2 AXIN2 ZC3H12A ZC3H12A RORA RORA RORC RORC JDP2 JDP2 TGFB1 TGFB1 ZFPM1 ZFPM1 CREBL2 CREBL2 ZBTB16 ZBTB16 LOC102350837 LOC102350837 LRP5 LRP5 DDIT3 DDIT3 ZFP36L1 ZFP36L1 LOC102345670 LOC102345670
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
WWTR1WW domain containing transcription regulator 1. (264 aa)
ZFPM2Zinc finger protein, FOG family member 2. (979 aa)
MEDAGMesenteric estrogen dependent adipogenesis. (268 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (259 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
BBS12Bardet-Biedl syndrome 12. (709 aa)
H2ZW26_LATCHUncharacterized protein. (352 aa)
LOC102346204Protein kinase domain-containing protein. (227 aa)
H2ZX66_LATCHUncharacterized protein. (641 aa)
CEBPBCCAAT/enhancer-binding protein. (291 aa)
ASXL2ASXL transcriptional regulator 2. (1399 aa)
STK4Serine/threonine kinase 4. (488 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (428 aa)
GATA3GATA binding protein 3. (447 aa)
ZNF385AZinc finger protein 385A. (403 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (263 aa)
YAP1Yes associated protein 1. (324 aa)
DLK2Delta like non-canonical Notch ligand 2. (340 aa)
WWTR1-2WW domain-containing protein. (159 aa)
KLF5Kruppel like factor 5. (435 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (635 aa)
METRNLMeteorin like, glial cell differentiation regulator. (288 aa)
VSTM2AV-set and transmembrane domain containing 2A. (237 aa)
LOC102358168G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
ZBTB7CZinc finger and BTB domain containing 7C. (581 aa)
TRIB3Tribbles pseudokinase 3. (353 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TMEM64Transmembrane protein 64. (350 aa)
E2F1E2F transcription factor 1. (411 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SIRT6Sirtuin 6. (375 aa)
SIRT1Sirtuin 1. (729 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (620 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (1795 aa)
H3AJR0_LATCHSRY-box transcription factor 13. (427 aa)
MMP11Matrix metallopeptidase 11. (473 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
RREB1Ras responsive element binding protein 1. (1516 aa)
SOX13Uncharacterized protein. (195 aa)
FLCNFolliculin. (576 aa)
LOC102350018CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (462 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3035 aa)
LOC102367007Uncharacterized protein. (335 aa)
WIF1WNT inhibitory factor 1. (379 aa)
LOC102360823G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
AXIN1Axin 1. (880 aa)
TPH1Tryptophan hydroxylase 1. (482 aa)
SAV1Salvador family WW domain containing protein 1. (393 aa)
ZFP36L2Uncharacterized protein. (394 aa)
H3AYC1_LATCHUncharacterized protein. (301 aa)
LOC102356748Formyl peptide receptor 1. (368 aa)
TAF8TATA-box binding protein associated factor 8. (315 aa)
CCDC85BCoiled-coil domain containing 85B. (194 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (403 aa)
H3B2C8_LATCHUncharacterized protein. (389 aa)
FNDC3BFibronectin type III domain containing 3B. (944 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (448 aa)
LOC102359601G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
FNDC5Fibronectin type III domain containing 5. (207 aa)
SORT1Sortilin. (734 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (560 aa)
H3B7I7_LATCHSb:cb81. (360 aa)
NOCTNocturnin. (446 aa)
CREB1cAMP responsive element binding protein 1. (347 aa)
DUSP10Dual specificity phosphatase 10. (481 aa)
LOC106701779Uncharacterized protein. (373 aa)
LOC102351049Kruppel-like factor 5 like. (387 aa)
LOC102346019C1q domain-containing protein. (226 aa)
AXIN2Axin 2. (841 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (600 aa)
RORARAR related orphan receptor A. (468 aa)
RORCRAR related orphan receptor C. (502 aa)
JDP2Jun dimerization protein 2. (164 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1017 aa)
CREBL2cAMP responsive element binding protein like 2. (121 aa)
ZBTB16Zinc finger and BTB domain containing 16. (420 aa)
LOC102350837G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
DDIT3DNA damage inducible transcript 3. (256 aa)
ZFP36L1ZFP36 ring finger protein like 1. (346 aa)
LOC102345670Sortilin. (809 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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