(25 nodes) Negative regulation of fat cell differentiation network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WWTR1	WW domain containing transcription regulator 1. (264 aa)
	ZADH2	Zinc binding alcohol dehydrogenase domain containing 2. (403 aa)
	SORT1	Sortilin. (734 aa)
	JDP2	Jun dimerization protein 2. (164 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (1017 aa)
	DDIT3	DNA damage inducible transcript 3. (256 aa)
	CCDC85B	Coiled-coil domain containing 85B. (194 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC102345670	Sortilin. (809 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3035 aa)
	FLCN	Folliculin. (576 aa)
	MMP11	Matrix metallopeptidase 11. (473 aa)
	SIRT1	Sirtuin 1. (729 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	E2F1	E2F transcription factor 1. (411 aa)
	TRIB3	Tribbles pseudokinase 3. (353 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (635 aa)
	WWTR1-2	WW domain-containing protein. (159 aa)
	YAP1	Yes associated protein 1. (324 aa)
	GATA3	GATA binding protein 3. (447 aa)
	BBS12	Bardet-Biedl syndrome 12. (709 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (979 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
ARNTL	SIRT1	ENSLACP00000005211	ENSLACP00000009079	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.845
DDIT3	TRIB3	ENSLACP00000021463	ENSLACP00000006545	DNA damage inducible transcript 3.	Tribbles pseudokinase 3.	0.599
E2F1	SIRT1	ENSLACP00000007825	ENSLACP00000009079	E2F transcription factor 1.	Sirtuin 1.	0.613
GATA3	ZFPM1	ENSLACP00000003446	ENSLACP00000020932	GATA binding protein 3.	Zinc finger protein, FOG family member 1.	0.767
GATA3	ZFPM2	ENSLACP00000003446	ENSLACP00000000328	GATA binding protein 3.	Zinc finger protein, FOG family member 2.	0.630
JAG1	TGFB1	ENSLACP00000001302	ENSLACP00000020652	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.550
SIRT1	ADIPOQ	ENSLACP00000009079	ENSLACP00000000452	Sirtuin 1.	Adiponectin, C1Q and collagen domain containing.	0.648
SIRT1	ARNTL	ENSLACP00000009079	ENSLACP00000005211	Sirtuin 1.	Aryl hydrocarbon receptor nuclear translocator like.	0.845
SIRT1	E2F1	ENSLACP00000009079	ENSLACP00000007825	Sirtuin 1.	E2F transcription factor 1.	0.613
TGFB1	JAG1	ENSLACP00000020652	ENSLACP00000001302	Transforming growth factor beta; Belongs to the TGF-beta family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.550
TRIB3	DDIT3	ENSLACP00000006545	ENSLACP00000021463	Tribbles pseudokinase 3.	DNA damage inducible transcript 3.	0.599
WWTR1	WWTR1-2	ENSLACP00000000109	ENSLACP00000004339	WW domain containing transcription regulator 1.	WW domain-containing protein.	0.917
WWTR1-2	WWTR1	ENSLACP00000004339	ENSLACP00000000109	WW domain-containing protein.	WW domain containing transcription regulator 1.	0.917
WWTR1-2	YAP1	ENSLACP00000004339	ENSLACP00000003752	WW domain-containing protein.	Yes associated protein 1.	0.949
YAP1	WWTR1-2	ENSLACP00000003752	ENSLACP00000004339	Yes associated protein 1.	WW domain-containing protein.	0.949
ZFPM1	GATA3	ENSLACP00000020932	ENSLACP00000003446	Zinc finger protein, FOG family member 1.	GATA binding protein 3.	0.767
ZFPM2	GATA3	ENSLACP00000000328	ENSLACP00000003446	Zinc finger protein, FOG family member 2.	GATA binding protein 3.	0.630