(30 nodes) Regulation of T-helper cell differentiation network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA3	GATA binding protein 3. (447 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	IL18	Uncharacterized protein. (200 aa)
	H3BI75_LATCH	Uncharacterized protein. (110 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	H3B5B6_LATCH	NACHT domain-containing protein. (692 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	H3ASJ2_LATCH	ANK_REP_REGION domain-containing protein. (303 aa)
	H3AQ35_LATCH	NACHT domain-containing protein. (880 aa)
	H3APC7_LATCH	NACHT domain-containing protein. (686 aa)
	H3ALU7_LATCH	NACHT domain-containing protein. (877 aa)
	LOC102346566	Annexin. (343 aa)
	HLX	H2.0 like homeobox. (384 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	H3ABW1_LATCH	ANK_REP_REGION domain-containing protein. (323 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	H3A7T5_LATCH	Uncharacterized protein. (999 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	LOC102348725	Uncharacterized protein. (641 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	SOCS5	Suppressor of cytokine signaling 5. (538 aa)
	H2ZX20_LATCH	Uncharacterized protein. (1016 aa)
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	RC3H2	RING-type domain-containing protein. (352 aa)
	H2ZSP9_LATCH	Uncharacterized protein. (997 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA3	MYB	ENSLACP00000003446	ENSLACP00000003141	GATA binding protein 3.	MYB proto-oncogene, transcription factor.	0.604
GATA3	TBX21	ENSLACP00000003446	ENSLACP00000019310	GATA binding protein 3.	T-box transcription factor 21.	0.735
H2ZSX8_LATCH	SOCS5	ENSLACP00000000499	ENSLACP00000002955	Fibronectin type-III domain-containing protein.	Suppressor of cytokine signaling 5.	0.530
H3AGM7_LATCH	SOCS5	ENSLACP00000008798	ENSLACP00000002955	Fibronectin type-III domain-containing protein.	Suppressor of cytokine signaling 5.	0.530
H3B0U4_LATCH	LOC102353021	ENSLACP00000015515	ENSLACP00000018014	MALT paracaspase 2.	Uncharacterized protein.	0.906
H3B0U4_LATCH	MALT1	ENSLACP00000015515	ENSLACP00000004155	MALT paracaspase 2.	MALT1 paracaspase.	0.902
H3BI75_LATCH	RC3H1	ENSLACP00000021596	ENSLACP00000018376	Uncharacterized protein.	Ring finger and CCCH-type domains 1.	0.510
HLX	TBX21	ENSLACP00000010162	ENSLACP00000019310	H2.0 like homeobox.	T-box transcription factor 21.	0.559
LOC102348796	RIPK2	ENSLACP00000023619	ENSLACP00000004499	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.900
LOC102353021	H3B0U4_LATCH	ENSLACP00000018014	ENSLACP00000015515	Uncharacterized protein.	MALT paracaspase 2.	0.906
LOC102353021	MALT1	ENSLACP00000018014	ENSLACP00000004155	Uncharacterized protein.	MALT1 paracaspase.	0.902
MALT1	H3B0U4_LATCH	ENSLACP00000004155	ENSLACP00000015515	MALT1 paracaspase.	MALT paracaspase 2.	0.902
MALT1	LOC102353021	ENSLACP00000004155	ENSLACP00000018014	MALT1 paracaspase.	Uncharacterized protein.	0.902
MYB	GATA3	ENSLACP00000003141	ENSLACP00000003446	MYB proto-oncogene, transcription factor.	GATA binding protein 3.	0.604
NFKBIZ	ZC3H12A	ENSLACP00000007879	ENSLACP00000019750	NFKB inhibitor zeta.	Zinc finger CCCH-type containing 12A.	0.479
RC3H1	H3BI75_LATCH	ENSLACP00000018376	ENSLACP00000021596	Ring finger and CCCH-type domains 1.	Uncharacterized protein.	0.510
RC3H1	RC3H2	ENSLACP00000018376	ENSLACP00000000453	Ring finger and CCCH-type domains 1.	RING-type domain-containing protein.	0.514
RC3H1	ZC3H12A	ENSLACP00000018376	ENSLACP00000019750	Ring finger and CCCH-type domains 1.	Zinc finger CCCH-type containing 12A.	0.554
RC3H2	RC3H1	ENSLACP00000000453	ENSLACP00000018376	RING-type domain-containing protein.	Ring finger and CCCH-type domains 1.	0.514
RIPK2	LOC102348796	ENSLACP00000004499	ENSLACP00000023619	Receptor interacting serine/threonine kinase 2.	Uncharacterized protein.	0.900