(37 nodes) Negative regulation of neuron differentiation network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	CNTN2	Contactin 2. (1026 aa)
	FOXG1	Forkhead box G1. (409 aa)
	ISL1	ISL LIM homeobox 1. (356 aa)
	DISP3	Dispatched RND transporter family member 3. (1355 aa)
	IRX3	Iroquois homeobox 3. (447 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	ISL2	ISL LIM homeobox 2. (360 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (121 aa)
	LOC102355848	Uncharacterized protein. (306 aa)
	LOC102357614	Fork-head domain-containing protein. (345 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	NEPRO	Nucleolus and neural progenitor protein. (529 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	PAX6	Paired box 6. (463 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (989 aa)
	ZHX2	Zinc fingers and homeoboxes 2. (828 aa)
	LOC102353832	Uncharacterized protein. (170 aa)
	LOC102360373	Fork-head domain-containing protein. (374 aa)
	MAG	Myelin associated glycoprotein. (633 aa)
	PHOX2B	Paired like homeobox 2B. (287 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	DLX1	Distal-less homeobox 1. (253 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	DLX2	Distal-less homeobox 2. (278 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1410 aa)
	LOC102353790	Uncharacterized protein. (899 aa)
	CNTF	Uncharacterized protein. (206 aa)
	TP73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	DIXDC1	DIX domain containing 1. (695 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (973 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (477 aa)
	H3B6W4_LATCH	Uncharacterized protein. (1169 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	CNTN2	ENSLACP00000001643	ENSLACP00000015722	Amyloid beta precursor protein.	Contactin 2.	0.774
CNTN2	APP	ENSLACP00000015722	ENSLACP00000001643	Contactin 2.	Amyloid beta precursor protein.	0.774
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	MIB1	ENSLACP00000009351	ENSLACP00000008377	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.426
DLL1	NOTCH3	ENSLACP00000009351	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	JAG1	ENSLACP00000008690	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.486
DLL3	LOC102353790	ENSLACP00000008690	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.973
DLL3	MIB1	ENSLACP00000008690	ENSLACP00000008377	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.426
DLL3	NOTCH3	ENSLACP00000008690	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.973
DLX1	DLX2	ENSLACP00000002197	ENSLACP00000001538	Distal-less homeobox 1.	Distal-less homeobox 2.	0.798
DLX2	DLX1	ENSLACP00000001538	ENSLACP00000002197	Distal-less homeobox 2.	Distal-less homeobox 1.	0.798
DLX2	FOXG1	ENSLACP00000001538	ENSLACP00000014746	Distal-less homeobox 2.	Forkhead box G1.	0.435
DLX2	PAX6	ENSLACP00000001538	ENSLACP00000017411	Distal-less homeobox 2.	Paired box 6.	0.511
EIF4ENIF1	LSM1	ENSLACP00000019222	ENSLACP00000012427	Eukaryotic translation initiation factor 4E nuclear import factor 1.	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	0.433
FOXG1	DLX2	ENSLACP00000014746	ENSLACP00000001538	Forkhead box G1.	Distal-less homeobox 2.	0.435
FOXG1	LOC102360373	ENSLACP00000014746	ENSLACP00000006831	Forkhead box G1.	Fork-head domain-containing protein.	0.902
FOXG1	PAX6	ENSLACP00000014746	ENSLACP00000017411	Forkhead box G1.	Paired box 6.	0.614