STRINGSTRING
SYNJ2BP SYNJ2BP EFNA1 EFNA1 LEP LEP KDR KDR ADGRB3 ADGRB3 TEK TEK ANGPT2 ANGPT2 EMILIN1 EMILIN1 FOXO4 FOXO4 NAXE NAXE H3AM01_LATCH H3AM01_LATCH VEGFA VEGFA PIK3CD PIK3CD NFE2L2 NFE2L2 E2F2 E2F2 GAB1 GAB1 TNN TNN DLL1 DLL1 TBC1D31 TBC1D31 SIRT1 SIRT1 VASH2 VASH2 YJEFN3 YJEFN3 APLNR APLNR ANGPTL3 ANGPTL3 RAMP2 RAMP2 SERPINE1 SERPINE1 JUP JUP CTSH CTSH LOC102356182 LOC102356182 CHRNA7 CHRNA7 BRCA1 BRCA1 GREM1 GREM1 TIE1 TIE1 SFRP2 SFRP2 TGFB2 TGFB2 LOC102361457 LOC102361457 ECM1 ECM1 H3AEK5_LATCH H3AEK5_LATCH H3AEV1_LATCH H3AEV1_LATCH HSPB1 HSPB1 BTG1 BTG1 DLL3 DLL3 RECK RECK SIRT6 SIRT6 H2ZS97_LATCH H2ZS97_LATCH H2ZSZ7_LATCH H2ZSZ7_LATCH ADM2 ADM2 KRIT1 KRIT1 ANXA3 ANXA3 CCBE1 CCBE1 H2ZUZ3_LATCH H2ZUZ3_LATCH ENPP2 ENPP2 DCN DCN ITGB8 ITGB8 H2ZVK6_LATCH H2ZVK6_LATCH LOC102358853 LOC102358853 GLUL GLUL LRG1 LRG1 SERPINF1 SERPINF1 GATA6 GATA6 THBS2 THBS2 ADGRB2 ADGRB2 WARS1 WARS1 LOC102348625 LOC102348625 DDAH2 DDAH2 CD40 CD40 TGFBR2 TGFBR2 LOC102360946 LOC102360946 LOC102363383 LOC102363383 IGF2 IGF2 EFNA3 EFNA3 MINAR1 MINAR1 IL10 IL10 VEGFB VEGFB ENG ENG HGS HGS VEGFC VEGFC APOH APOH BMPER BMPER PROK2 PROK2 ACVRL1 ACVRL1 RAPGEF3 RAPGEF3 PGF PGF CD34 CD34 MDK MDK CREB3L1 CREB3L1 GTF2I GTF2I THBS1 THBS1 MYDGF MYDGF LOC102354490 LOC102354490 FLT1 FLT1 ZC3H12A ZC3H12A HOXA5 HOXA5 LOC102352268 LOC102352268 DDAH1 DDAH1 NF1 NF1 FGF2 FGF2 LOC102349421 LOC102349421 LOC102362765 LOC102362765 ABCC8 ABCC8 SULF1 SULF1 H3B845_LATCH H3B845_LATCH EMC10 EMC10 SEMA3E SEMA3E VEGFD VEGFD ROCK2 ROCK2 H3B7E6_LATCH H3B7E6_LATCH NR2E1 NR2E1 FASLG FASLG LOC102361837 LOC102361837 CLDN5 CLDN5 GATA2 GATA2 CTNNB1 CTNNB1 LOC102350639 LOC102350639 TBXA2R TBXA2R LOC102360304 LOC102360304 VASH1 VASH1 LOC102360711 LOC102360711 H3B2C8_LATCH H3B2C8_LATCH ROCK1 ROCK1 SEMA4A SEMA4A FGF18 FGF18 CEMIP2 CEMIP2 LOC102361405 LOC102361405 FGF1 FGF1 PIK3CB PIK3CB H3AYV3_LATCH H3AYV3_LATCH H3AYQ4_LATCH H3AYQ4_LATCH TSPAN12 TSPAN12 FKBPL FKBPL AGGF1 AGGF1 CEMIP CEMIP C5 C5 HTATIP2 HTATIP2 PLXND1 PLXND1 RGCC RGCC STAT3 STAT3 SP1 SP1 ATP2B4 ATP2B4 EPHA2 EPHA2 LOC102355176 LOC102355176 SPRED1 SPRED1 TLR3 TLR3 MECP2 MECP2 SMAD1 SMAD1 CDH5 CDH5 JMJD8 JMJD8 STIM1 STIM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYNJ2BPPDZ domain-containing protein. (107 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (176 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
ADGRB3Adhesion G protein-coupled receptor B3. (432 aa)
TEKTEK receptor tyrosine kinase. (914 aa)
ANGPT2Angiopoietin 2. (493 aa)
EMILIN1Elastin microfibril interfacer 1. (1047 aa)
FOXO4Forkhead box O4. (554 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (292 aa)
H3AM01_LATCHIntegrin beta; Belongs to the integrin beta chain family. (769 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (189 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1006 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (590 aa)
E2F2E2F transcription factor 2. (435 aa)
GAB1GRB2 associated binding protein 1. (534 aa)
TNNTenascin N. (831 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TBC1D31TBC1 domain family member 31. (1092 aa)
SIRT1Sirtuin 1. (729 aa)
VASH2Vasohibin 2. (370 aa)
YJEFN3YjeF N-terminal domain containing 3. (202 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ANGPTL3Angiopoietin like 3. (454 aa)
RAMP2Uncharacterized protein. (146 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (403 aa)
JUPJunction plakoglobin. (694 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
CHRNA7Cholinergic receptor, nicotinic, alpha 7 (neuronal). (506 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
LOC102361457G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ECM1Uncharacterized protein. (366 aa)
H3AEK5_LATCHAquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (219 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (952 aa)
SIRT6Sirtuin 6. (375 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
H2ZSZ7_LATCHAdhesion G protein-coupled receptor B3. (586 aa)
ADM2Adrenomedullin 2. (114 aa)
KRIT1KRIT1 ankyrin repeat containing. (733 aa)
ANXA3Annexin. (323 aa)
CCBE1Collagen and calcium binding EGF domains 1. (357 aa)
H2ZUZ3_LATCHUncharacterized protein. (515 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (893 aa)
DCNDecorin; May affect the rate of fibrils formation. (353 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (637 aa)
H2ZVK6_LATCHUncharacterized protein; Belongs to the argonaute family. (861 aa)
LOC102358853Uncharacterized protein. (577 aa)
GLULGlutamine synthetase. (408 aa)
LRG1LRRCT domain-containing protein. (337 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (420 aa)
GATA6GATA binding protein 6. (503 aa)
THBS2Uncharacterized protein. (1177 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1548 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa)
LOC102348625Adhesion G protein-coupled receptor B1a. (589 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (295 aa)
CD40TNFR-Cys domain-containing protein. (167 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
LOC102360946G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (332 aa)
LOC102363383EF-hand domain-containing protein; Belongs to the S-100 family. (100 aa)
IGF2Insulin like growth factor 2. (207 aa)
EFNA3Ephrin-A3b; Belongs to the ephrin family. (186 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (910 aa)
IL10Interleukin 10. (185 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (148 aa)
ENGEndoglin. (674 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (480 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
APOHApolipoprotein H. (351 aa)
BMPERBMP binding endothelial regulator. (682 aa)
PROK2Prokineticin 2. (159 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
RAPGEF3Ras-GEF domain-containing protein. (459 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (132 aa)
CD34Uncharacterized protein. (378 aa)
MDKMidkine. (141 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (481 aa)
GTF2IGeneral transcription factor IIi. (911 aa)
THBS1Thrombospondin 1. (1170 aa)
MYDGFMyeloid derived growth factor. (85 aa)
LOC102354490Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (600 aa)
HOXA5Homeobox A5. (269 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (283 aa)
NF1Neurofibromin 1. (2814 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC102349421Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
LOC102362765Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
ABCC8ATP binding cassette subfamily C member 8. (1591 aa)
SULF1Sulfatase 1. (1129 aa)
H3B845_LATCHG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (299 aa)
EMC10ER membrane protein complex subunit 10. (253 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (739 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (341 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
H3B7E6_LATCHUncharacterized protein. (237 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (477 aa)
FASLGFas ligand. (261 aa)
LOC102361837Glutamine synthetase. (370 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
GATA2GATA binding protein 2. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC102350639G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
TBXA2RThromboxane A2 receptor. (351 aa)
LOC102360304G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
VASH1Vasohibin 1. (363 aa)
LOC102360711PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
H3B2C8_LATCHUncharacterized protein. (389 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
SEMA4ASema domain-containing protein; Belongs to the semaphorin family. (758 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
CEMIP2Cell migration inducing hyaluronidase 2. (1380 aa)
LOC102361405PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (140 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
H3AYV3_LATCHUncharacterized protein. (962 aa)
H3AYQ4_LATCHUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)
TSPAN12Tetraspanin 12; Belongs to the tetraspanin (TM4SF) family. (236 aa)
FKBPLFKBP prolyl isomerase like. (269 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1. (703 aa)
CEMIPCell migration inducing hyaluronidase 1. (1336 aa)
C5Complement C5. (1691 aa)
HTATIP2HIV-1 Tat interactive protein 2. (275 aa)
PLXND1Plexin D1. (1875 aa)
RGCCRegulator of cell cycle. (127 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
SP1Sp1 transcription factor. (754 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1233 aa)
EPHA2Uncharacterized protein. (979 aa)
LOC102355176G8 domain-containing protein. (1268 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
MECP2Methyl-CpG binding protein 2. (459 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CDH5Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
JMJD8Jumonji domain containing 8. (268 aa)
STIM1Stromal interaction molecule 1. (662 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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