(40 nodes) Negative regulation of gene expression, epigenetic network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BEND3	BEN domain containing 3. (842 aa)
	LOC102353313	Si:ch73-41e3.7. (357 aa)
	RRP8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (469 aa)
	CENPV	Centromere protein V. (159 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1938 aa)
	POLE3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa)
	MORC2	MORC family CW-type zinc finger 2. (1039 aa)
	BAHD1	Bromo adjacent homology domain containing 1. (735 aa)
	LOC102347052	Uncharacterized protein; Belongs to the intermediate filament family. (587 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (636 aa)
	FAM172A	Family with sequence similarity 172 member A. (425 aa)
	MBD3	Methyl-CpG binding domain protein 3a. (277 aa)
	CREBZF	CREB/ATF bZIP transcription factor. (300 aa)
	HELLS	Helicase, lymphoid specific. (874 aa)
	MBD2	Methyl-CpG binding domain protein 2. (267 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (612 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (376 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1. (2046 aa)
	LOC102350798	Uncharacterized protein. (1745 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (678 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (759 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1767 aa)
	H3AUS9_LATCH	BAH domain-containing protein. (149 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (370 aa)
	MECP2	Methyl-CpG binding protein 2. (459 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (750 aa)
	SPTY2D1	SPT2 chromatin protein domain containing 1. (604 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (988 aa)
	SMYD5	SMYD family member 5. (314 aa)
	MPHOSPH8	M-phase phosphoprotein 8. (962 aa)
	SIRT1	Sirtuin 1. (729 aa)
	SIRT6	Sirtuin 6. (375 aa)
	TASOR	Transcription activation suppressor. (1626 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (420 aa)
	RIF1	Replication timing regulatory factor 1. (2351 aa)
	RB1	Uncharacterized protein. (411 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (589 aa)
	EPC1	Enhancer of polycomb homolog. (811 aa)
	H2ZWS3_LATCH	DBF4-type domain-containing protein. (385 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNMT1	EZH1	ENSLACP00000012502	ENSLACP00000014514	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.865
DNMT1	EZH2	ENSLACP00000012502	ENSLACP00000011122	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.914
DNMT1	HELLS	ENSLACP00000012502	ENSLACP00000018531	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Helicase, lymphoid specific.	0.424
DNMT1	MACROH2A1	ENSLACP00000012502	ENSLACP00000013357	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.407
DNMT1	MACROH2A2	ENSLACP00000012502	ENSLACP00000016927	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.407
DNMT1	MBD2	ENSLACP00000012502	ENSLACP00000018207	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding domain protein 2.	0.536
DNMT1	MBD3	ENSLACP00000012502	ENSLACP00000018741	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding domain protein 3a.	0.536
DNMT1	MECP2	ENSLACP00000012502	ENSLACP00000012808	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding protein 2.	0.788
DNMT1	RB1	ENSLACP00000012502	ENSLACP00000005360	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.403
DNMT1	SIRT1	ENSLACP00000012502	ENSLACP00000009079	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Sirtuin 1.	0.598
DOT1L	EZH1	ENSLACP00000010704	ENSLACP00000014514	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.548
DOT1L	EZH2	ENSLACP00000010704	ENSLACP00000011122	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.414
DOT1L	MACROH2A1	ENSLACP00000010704	ENSLACP00000013357	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.517
DOT1L	MACROH2A2	ENSLACP00000010704	ENSLACP00000016927	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.517
DOT1L	SIRT1	ENSLACP00000010704	ENSLACP00000009079	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Sirtuin 1.	0.808
DOT1L	SMYD5	ENSLACP00000010704	ENSLACP00000010497	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	SMYD family member 5.	0.544
EPC1	EZH1	ENSLACP00000004709	ENSLACP00000014514	Enhancer of polycomb homolog.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.639
EPC1	EZH2	ENSLACP00000004709	ENSLACP00000011122	Enhancer of polycomb homolog.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.639
EZH1	DNMT1	ENSLACP00000014514	ENSLACP00000012502	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.865
EZH1	DOT1L	ENSLACP00000014514	ENSLACP00000010704	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.548