(16 nodes) Positive regulation of heart contraction network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	ADM2	Adrenomedullin 2. (114 aa)
	ADRA1A	Adrenoceptor alpha 1A. (459 aa)
	ADRA1D	Adrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family. (309 aa)
	LOC102348461	G_PROTEIN_RECEP_F1_2 domain-containing protein. (373 aa)
	H3AHJ4_LATCH	Ion_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
	UCN	Urocortin. (167 aa)
	LOC102359447	GTP cyclohydrolase 2. (241 aa)
	SCN3B	Sodium voltage-gated channel beta subunit 3. (216 aa)
	ADRA1B	Adrenoceptor alpha 1B. (473 aa)
	NKX2-5	NK2 homeobox 5. (296 aa)
	EDN1	Endothelin 1. (216 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	ADM	Adrenomedullin. (198 aa)
	GCH1	GTP cyclohydrolase 1. (252 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADM	ADM2	ENSLACP00000020653	ENSLACP00000000674	Adrenomedullin.	Adrenomedullin 2.	0.665
ADM	EDN1	ENSLACP00000020653	ENSLACP00000018825	Adrenomedullin.	Endothelin 1.	0.497
ADM2	ADM	ENSLACP00000000674	ENSLACP00000020653	Adrenomedullin 2.	Adrenomedullin.	0.665
ADRA1A	ADRA1B	ENSLACP00000001831	ENSLACP00000014208	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1B.	0.435
ADRA1A	ADRA1D	ENSLACP00000001831	ENSLACP00000002835	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family.	0.412
ADRA1A	EDN1	ENSLACP00000001831	ENSLACP00000018825	Adrenoceptor alpha 1A.	Endothelin 1.	0.654
ADRA1A	LOC102348461	ENSLACP00000001831	ENSLACP00000007296	Adrenoceptor alpha 1A.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.415
ADRA1B	ADRA1A	ENSLACP00000014208	ENSLACP00000001831	Adrenoceptor alpha 1B.	Adrenoceptor alpha 1A.	0.435
ADRA1B	EDN1	ENSLACP00000014208	ENSLACP00000018825	Adrenoceptor alpha 1B.	Endothelin 1.	0.525
ADRA1D	ADRA1A	ENSLACP00000002835	ENSLACP00000001831	Adrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family.	Adrenoceptor alpha 1A.	0.412
ADRA1D	EDN1	ENSLACP00000002835	ENSLACP00000018825	Adrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.525
EDN1	ADM	ENSLACP00000018825	ENSLACP00000020653	Endothelin 1.	Adrenomedullin.	0.497
EDN1	ADRA1A	ENSLACP00000018825	ENSLACP00000001831	Endothelin 1.	Adrenoceptor alpha 1A.	0.654
EDN1	ADRA1B	ENSLACP00000018825	ENSLACP00000014208	Endothelin 1.	Adrenoceptor alpha 1B.	0.525
EDN1	ADRA1D	ENSLACP00000018825	ENSLACP00000002835	Endothelin 1.	Adrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family.	0.525
EDN1	LOC102348461	ENSLACP00000018825	ENSLACP00000007296	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.525
EDN1	NKX2-5	ENSLACP00000018825	ENSLACP00000016921	Endothelin 1.	NK2 homeobox 5.	0.420
GCH1	LOC102359447	ENSLACP00000021689	ENSLACP00000012093	GTP cyclohydrolase 1.	GTP cyclohydrolase 2.	0.901
LOC102348461	ADRA1A	ENSLACP00000007296	ENSLACP00000001831	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Adrenoceptor alpha 1A.	0.415
LOC102348461	EDN1	ENSLACP00000007296	ENSLACP00000018825	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Endothelin 1.	0.525