(22 nodes) Positive regulation of smoothened signaling pathway network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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textmining

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Your Input:
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	GAS1	Growth arrest specific 1. (259 aa)
	H2ZUH0_LATCH	Uncharacterized protein. (1420 aa)
	ULK3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (471 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	GAS8	Growth arrest specific 8. (482 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
	EVC	EvC ciliary complex subunit 1. (814 aa)
	STK36	Serine/threonine kinase 36. (1346 aa)
	TXNDC15	Thioredoxin domain containing 15. (349 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	ARMC9	Armadillo repeat containing 9. (445 aa)
	FAM92A	Family with sequence similarity 92 member A. (288 aa)
	TTC23	Tetratricopeptide repeat domain 23. (445 aa)
	H3AMW9_LATCH	Uncharacterized protein. (2007 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	TUBD1	Tubulin delta 1; Belongs to the tubulin family. (452 aa)
	SCUBE3	Signal peptide, CUB domain and EGF like domain containing 3. (958 aa)
	INTU	Inturned planar cell polarity protein. (960 aa)
	SCUBE2	Signal peptide, CUB domain and EGF like domain containing 2. (991 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (424 aa)
	GLI1	GLI family zinc finger 1. (1380 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC9	TTC23	ENSLACP00000008317	ENSLACP00000010481	Armadillo repeat containing 9.	Tetratricopeptide repeat domain 23.	0.420
DHH	GAS1	ENSLACP00000021608	ENSLACP00000000732	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Growth arrest specific 1.	0.527
DHH	IHH	ENSLACP00000021608	ENSLACP00000004851	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.904
DHH	SCUBE2	ENSLACP00000021608	ENSLACP00000019644	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Signal peptide, CUB domain and EGF like domain containing 2.	0.497
DHH	SHH	ENSLACP00000021608	ENSLACP00000013019	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.903
DHH	SMO	ENSLACP00000021608	ENSLACP00000002758	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.760
DLG5	EVC	ENSLACP00000005485	ENSLACP00000007138	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	EvC ciliary complex subunit 1.	0.441
EVC	DLG5	ENSLACP00000007138	ENSLACP00000005485	EvC ciliary complex subunit 1.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.441
EVC	GLI1	ENSLACP00000007138	ENSLACP00000021691	EvC ciliary complex subunit 1.	GLI family zinc finger 1.	0.575
EVC	SMO	ENSLACP00000007138	ENSLACP00000002758	EvC ciliary complex subunit 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.802
FAM92A	TTC23	ENSLACP00000008524	ENSLACP00000010481	Family with sequence similarity 92 member A.	Tetratricopeptide repeat domain 23.	0.451
FAM92A	TXNDC15	ENSLACP00000008524	ENSLACP00000007973	Family with sequence similarity 92 member A.	Thioredoxin domain containing 15.	0.420
GAS1	DHH	ENSLACP00000000732	ENSLACP00000021608	Growth arrest specific 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.527
GAS1	GLI1	ENSLACP00000000732	ENSLACP00000021691	Growth arrest specific 1.	GLI family zinc finger 1.	0.441
GAS1	IHH	ENSLACP00000000732	ENSLACP00000004851	Growth arrest specific 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.616
GAS1	SHH	ENSLACP00000000732	ENSLACP00000013019	Growth arrest specific 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.695
GAS1	SMO	ENSLACP00000000732	ENSLACP00000002758	Growth arrest specific 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.666
GAS8	SMO	ENSLACP00000003689	ENSLACP00000002758	Growth arrest specific 8.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.690
GLI1	EVC	ENSLACP00000021691	ENSLACP00000007138	GLI family zinc finger 1.	EvC ciliary complex subunit 1.	0.575
GLI1	GAS1	ENSLACP00000021691	ENSLACP00000000732	GLI family zinc finger 1.	Growth arrest specific 1.	0.441