(27 nodes) Regulation of glucose import network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	RNASEL	Uncharacterized protein. (698 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (855 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (133 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	H3ADV1_LATCH	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (974 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	SIRT6	Sirtuin 6. (375 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	OPN3	Opsin 3; Belongs to the G-protein coupled receptor 1 family. (155 aa)
	ASPSCR1	UBX domain-containing protein. (597 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	SLC1A2	Amino acid transporter. (566 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (597 aa)
	LOC102358762	Amino acid transporter. (538 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (671 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	OSTN	Osteocrin. (136 aa)
	CREBL2	cAMP responsive element binding protein like 2. (121 aa)
	C1QTNF12	C1q and TNF related 12. (265 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (217 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL1	ENSLACP00000000452	ENSLACP00000012610	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.555
ADIPOQ	APPL2	ENSLACP00000000452	ENSLACP00000000307	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
ADIPOQ	H3A2B0_LATCH	ENSLACP00000000452	ENSLACP00000003781	Adiponectin, C1Q and collagen domain containing.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
APPL1	ADIPOQ	ENSLACP00000012610	ENSLACP00000000452	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adiponectin, C1Q and collagen domain containing.	0.555
APPL1	APPL2	ENSLACP00000012610	ENSLACP00000000307	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.997
APPL1	C1QTNF9	ENSLACP00000012610	ENSLACP00000014983	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	C1q domain-containing protein.	0.554
APPL1	LOC102346019	ENSLACP00000012610	ENSLACP00000019134	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	C1q domain-containing protein.	0.554
APPL1	PEA15	ENSLACP00000012610	ENSLACP00000005163	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Proliferation and apoptosis adaptor protein 15.	0.686
APPL2	ADIPOQ	ENSLACP00000000307	ENSLACP00000000452	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.554
APPL2	APPL1	ENSLACP00000000307	ENSLACP00000012610	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.997
APPL2	C1QTNF9	ENSLACP00000000307	ENSLACP00000014983	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.554
APPL2	LOC102346019	ENSLACP00000000307	ENSLACP00000019134	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.554
APPL2	PEA15	ENSLACP00000000307	ENSLACP00000005163	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Proliferation and apoptosis adaptor protein 15.	0.686
C1QTNF9	APPL1	ENSLACP00000014983	ENSLACP00000012610	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.554
C1QTNF9	APPL2	ENSLACP00000014983	ENSLACP00000000307	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
C1QTNF9	LEP	ENSLACP00000014983	ENSLACP00000011398	C1q domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.631
FGF19	H3A2B0_LATCH	ENSLACP00000014596	ENSLACP00000003781	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.483
H3A2B0_LATCH	ADIPOQ	ENSLACP00000003781	ENSLACP00000000452	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Adiponectin, C1Q and collagen domain containing.	0.465