(63 nodes) Positive regulation of JNK cascade network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	CCN2	Cellular communication network factor 2. (344 aa)
	LOC102352645	TAO kinase 2b. (1109 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (635 aa)
	PJA2	Uncharacterized protein. (546 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	MINK1	Misshapen like kinase 1. (1320 aa)
	SH3RF3	SH3 domain containing ring finger 3. (773 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	EDAR	Ectodysplasin A receptor. (454 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (160 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	ANKRD6	Ankyrin repeat domain 6. (791 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	RB1CC1	RB1-inducible coiled-coil 1. (1296 aa)
	DUSP19	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (213 aa)
	LTBR	Lymphotoxin beta receptor. (377 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	H3AMM0_LATCH	ATG11 domain-containing protein. (241 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase 11. (831 aa)
	TRAF4	TNF receptor-associated factor. (434 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	H3APL3_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (534 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	SH3RF1	SH3 domain containing ring finger 1. (745 aa)
	LOC102354453	Uncharacterized protein. (230 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	TNIK	TRAF2 and NCK interacting kinase. (1320 aa)
	ZNF622	Zinc finger protein 622. (471 aa)
	NAIP	NLR family apoptosis inhibitory protein. (1422 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	H3AZ94_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TAOK1	TAO kinase 1. (1003 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (439 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
	H3B1U1_LATCH	RING-type domain-containing protein. (527 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	H3B5C9_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	H3B7S8_LATCH	TNF receptor-associated factor. (449 aa)
	UNC5CL	Unc-5 family C-terminal like. (528 aa)
	TAOK3	TAO kinase 3. (1034 aa)
	LOC102354674	Uncharacterized protein. (1272 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	MBIP	MAP3K12 binding inhibitory protein 1. (348 aa)
	NCF1	Neutrophil cytosolic factor 1. (416 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	DIXDC1	DIX domain containing 1. (695 aa)
	TPD52L1	TPD52 like 1. (190 aa)
	LOC102355628	TMEM219 domain-containing protein. (300 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (463 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD6	APP	ENSLACP00000006882	ENSLACP00000001643	Ankyrin repeat domain 6.	Amyloid beta precursor protein.	0.744
ANKRD6	MYD88	ENSLACP00000006882	ENSLACP00000019094	Ankyrin repeat domain 6.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.504
ANKRD6	TRAF6	ENSLACP00000006882	ENSLACP00000003556	Ankyrin repeat domain 6.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.419
APP	ANKRD6	ENSLACP00000001643	ENSLACP00000006882	Amyloid beta precursor protein.	Ankyrin repeat domain 6.	0.744
CARD9	LOC102348796	ENSLACP00000020146	ENSLACP00000023619	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.936
CARD9	MYD88	ENSLACP00000020146	ENSLACP00000019094	Caspase recruitment domain family member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.547
CARD9	NOD1	ENSLACP00000020146	ENSLACP00000016876	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 1.	0.613
CARD9	NOD2	ENSLACP00000020146	ENSLACP00000011767	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 2.	0.613
CARD9	RIPK2	ENSLACP00000020146	ENSLACP00000004499	Caspase recruitment domain family member 9.	Receptor interacting serine/threonine kinase 2.	0.936
CARD9	TRAF6	ENSLACP00000020146	ENSLACP00000003556	Caspase recruitment domain family member 9.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.437
DUSP19	MAP2K7	ENSLACP00000008876	ENSLACP00000015207	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase kinase 7.	0.649
EDAR	SH3RF3	ENSLACP00000004634	ENSLACP00000004389	Ectodysplasin A receptor.	SH3 domain containing ring finger 3.	0.518
FGF19	FLT4	ENSLACP00000014596	ENSLACP00000022811	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.830
FLT4	FGF19	ENSLACP00000022811	ENSLACP00000014596	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.830
GADD45G	MAP2K7	ENSLACP00000004981	ENSLACP00000015207	Growth arrest and DNA damage inducible gamma.	Mitogen-activated protein kinase kinase 7.	0.456
H2ZS97_LATCH	LTBR	ENSLACP00000000268	ENSLACP00000008945	TNF_2 domain-containing protein.	Lymphotoxin beta receptor.	0.467
H3AEV1_LATCH	LTBR	ENSLACP00000008172	ENSLACP00000008945	TNF_2 domain-containing protein.	Lymphotoxin beta receptor.	0.467
H3AEV1_LATCH	TNFSF11	ENSLACP00000008172	ENSLACP00000009224	TNF_2 domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.448
H3AMM0_LATCH	RB1CC1	ENSLACP00000010891	ENSLACP00000008546	ATG11 domain-containing protein.	RB1-inducible coiled-coil 1.	0.925
H3APL3_LATCH	H3B1U1_LATCH	ENSLACP00000011584	ENSLACP00000015862	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	RING-type domain-containing protein.	0.536