STRINGSTRING
H3B8U3_LATCH H3B8U3_LATCH MTOR MTOR CCN1 CCN1 H3BDU0_LATCH H3BDU0_LATCH SNAI1 SNAI1 H3BE69_LATCH H3BE69_LATCH ABCG4 ABCG4 ENPP7 ENPP7 SIRT4 SIRT4 CREBL2 CREBL2 DDX20 DDX20 SF1 SF1 ORMDL2 ORMDL2 MLXIPL MLXIPL NR1H3 NR1H3 EIF6 EIF6 FGFR4 FGFR4 APOB APOB SCARB1 SCARB1 NR1H4 NR1H4 H2ZS97_LATCH H2ZS97_LATCH LOC102355368 LOC102355368 ABCD1 ABCD1 HTR2A HTR2A LOC102353315 LOC102353315 STARD4 STARD4 HTR2B HTR2B LPCAT3 LPCAT3 H2ZWV5_LATCH H2ZWV5_LATCH GPLD1 GPLD1 FAM3A FAM3A H2ZYB6_LATCH H2ZYB6_LATCH H2ZYH3_LATCH H2ZYH3_LATCH PDGFB PDGFB LOC102350164 LOC102350164 SCAP SCAP ARMC5 ARMC5 ABCG1 ABCG1 SAMD8 SAMD8 DGKQ DGKQ ACSL3 ACSL3 IGF2 IGF2 SREBF2 SREBF2 THRSP THRSP CGA CGA ABCD2 ABCD2 PODN PODN SNAI2 SNAI2 SLC45A3 SLC45A3 TRIB3 TRIB3 ZBTB20 ZBTB20 SIRT3 SIRT3 BRCA1 BRCA1 LOC102350759 LOC102350759 LOC102354799 LOC102354799 PLA2G6 PLA2G6 LTA LTA NR0B1 NR0B1 GPER1 GPER1 H3AEV1_LATCH H3AEV1_LATCH CYP7A1 CYP7A1 SIRT1 SIRT1 PTGS2 PTGS2 ERLIN1 ERLIN1 PIBF1 PIBF1 SPHK2 SPHK2 LOC102346566 LOC102346566 STAR STAR ASAH1 ASAH1 NR1D1 NR1D1 LEP LEP H3AP48_LATCH H3AP48_LATCH ERLIN2 ERLIN2 BMP6 BMP6 PPARA PPARA DKK3 DKK3 CNEP1R1 CNEP1R1 PRMT3 PRMT3 FITM2 FITM2 LPIN1 LPIN1 FGF19 FGF19 H3AYF7_LATCH H3AYF7_LATCH MFSD2A MFSD2A DAB2 DAB2 ABHD6 ABHD6 SREBF1 SREBF1 FGF1 FGF1 H3B0K2_LATCH H3B0K2_LATCH PODNL1 PODNL1 WDTC1 WDTC1 ORMDL1 ORMDL1 MID1IP1 MID1IP1 LOC102364376 LOC102364376 IDH1 IDH1 LOC102363939 LOC102363939 H6PD H6PD APOA4 APOA4 WNT4 WNT4 H3B5H1_LATCH H3B5H1_LATCH NR1H2 NR1H2 CREB1 CREB1 SPHK1 SPHK1 CD74 CD74
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
CCN1Cellular communication network factor 1. (368 aa)
H3BDU0_LATCHNAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (318 aa)
SNAI1Snail family transcriptional repressor 1. (257 aa)
H3BE69_LATCHPID domain-containing protein. (136 aa)
ABCG4ATP binding cassette subfamily G member 4. (653 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (476 aa)
SIRT4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
CREBL2cAMP responsive element binding protein like 2. (121 aa)
DDX20DEAD-box helicase 20. (805 aa)
SF1Splicing factor 1. (547 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (173 aa)
MLXIPLMLX interacting protein like. (862 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (375 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (136 aa)
FGFR4Fibroblast growth factor receptor. (810 aa)
APOBApolipoprotein B. (4644 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (456 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
LOC102355368NR LBD domain-containing protein. (170 aa)
ABCD1ATP binding cassette subfamily D member 1. (749 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
LOC102353315Uncharacterized protein. (381 aa)
STARD4StAR related lipid transfer domain containing 4. (216 aa)
HTR2B5-hydroxytryptamine receptor 2B. (474 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (430 aa)
H2ZWV5_LATCHSolute carrier family 27 member 1a. (655 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
FAM3AFamily with sequence similarity 3 member A. (227 aa)
H2ZYB6_LATCHUncharacterized protein. (324 aa)
H2ZYH3_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
LOC102350164Uncharacterized protein. (364 aa)
SCAPSREBF chaperone. (1283 aa)
ARMC5Armadillo repeat containing 5. (811 aa)
ABCG1ATP binding cassette subfamily G member 1. (649 aa)
SAMD8Sterile alpha motif domain containing 8. (470 aa)
DGKQDiacylglycerol kinase. (940 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (711 aa)
IGF2Insulin like growth factor 2. (207 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1083 aa)
THRSPThyroid hormone responsive. (137 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
ABCD2ATP binding cassette subfamily D member 2. (743 aa)
PODNPodocan. (621 aa)
SNAI2Snail family zinc finger 2. (268 aa)
SLC45A3Solute carrier family 45 member 3. (563 aa)
TRIB3Tribbles pseudokinase 3. (353 aa)
ZBTB20Zinc finger and BTB domain containing 20. (619 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
LOC102350759SEC14-like lipid binding 8. (356 aa)
LOC102354799Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
PLA2G6Phospholipase A2 group VI. (815 aa)
LTALymphotoxin alpha. (166 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (261 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1. (514 aa)
SIRT1Sirtuin 1. (729 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (620 aa)
ERLIN1ER lipid raft associated 1. (328 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (644 aa)
SPHK2Sphingosine kinase 2. (479 aa)
LOC102346566Annexin. (343 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (332 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
H3AP48_LATCHDickkopf_N domain-containing protein. (253 aa)
ERLIN2ER lipid raft associated 2. (338 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (508 aa)
FITM2Fat storage inducing transmembrane protein 2. (266 aa)
LPIN1Lipin 1. (938 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
H3AYF7_LATCHZgc:153896. (403 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (549 aa)
DAB2DAB adaptor protein 2. (745 aa)
ABHD6Abhydrolase domain containing 6. (294 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1100 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
H3B0K2_LATCHSTART domain-containing protein. (279 aa)
PODNL1Podocan like 1. (599 aa)
WDTC1WD and tetratricopeptide repeats 1. (646 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (170 aa)
MID1IP1MID1 interacting protein 1. (159 aa)
LOC102364376Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
LOC102363939ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (793 aa)
APOA4Apolipoprotein A4. (367 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
H3B5H1_LATCHMID1 interacting protein 1, like. (150 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (426 aa)
CREB1cAMP responsive element binding protein 1. (347 aa)
SPHK1Sphingosine kinase 1. (508 aa)
CD74CD74 molecule. (279 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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