(22 nodes) Platelet-derived growth factor receptor signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102357376	CSRNP_N domain-containing protein. (152 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	PDGFRL	Platelet derived growth factor receptor like. (377 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (914 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (439 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	LOC102347832	Si:dkey-193c22.2. (2393 aa)
	PDGFRA	Uncharacterized protein. (1094 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (215 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (566 aa)
	TXNIP	Thioredoxin interacting protein. (402 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (552 aa)
	LOC102347076	Uncharacterized protein. (232 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
	CSPG4	Chondroitin sulfate proteoglycan 4. (2343 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	LOC102362769	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
	LOC102350846	Ig-like domain-containing protein. (257 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (369 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
BCAR1	H3AM01_LATCH	ENSLACP00000003747	ENSLACP00000010672	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.615
BCAR1	PDGFRA	ENSLACP00000003747	ENSLACP00000010339	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein.	0.598
BCAR1	PDGFRB	ENSLACP00000003747	ENSLACP00000016550	BCAR1 scaffold protein, Cas family member.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.670
BCAR1	PTPN1	ENSLACP00000003747	ENSLACP00000004428	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein phosphatase non-receptor type.	0.662
CSPG4	PDGFRB	ENSLACP00000017041	ENSLACP00000016550	Chondroitin sulfate proteoglycan 4.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.490
H3AM01_LATCH	BCAR1	ENSLACP00000010672	ENSLACP00000003747	Integrin beta; Belongs to the integrin beta chain family.	BCAR1 scaffold protein, Cas family member.	0.615
H3AM01_LATCH	PTPN1	ENSLACP00000010672	ENSLACP00000004428	Integrin beta; Belongs to the integrin beta chain family.	Tyrosine-protein phosphatase non-receptor type.	0.501
LOC102347832	PDGFRB	ENSLACP00000006858	ENSLACP00000016550	Si:dkey-193c22.2.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.490
LOC102350846	NRP1	ENSLACP00000019762	ENSLACP00000023533	Ig-like domain-containing protein.	Neuropilin; Belongs to the neuropilin family.	0.650
LOC102350846	PDGFB	ENSLACP00000019762	ENSLACP00000002907	Ig-like domain-containing protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.687
LOC102350846	PDGFRB	ENSLACP00000019762	ENSLACP00000016550	Ig-like domain-containing protein.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.625
LOC102362769	PDGFRA	ENSLACP00000018269	ENSLACP00000010339	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2.	Uncharacterized protein.	0.536
NRP1	LOC102350846	ENSLACP00000023533	ENSLACP00000019762	Neuropilin; Belongs to the neuropilin family.	Ig-like domain-containing protein.	0.650
NRP1	PDGFB	ENSLACP00000023533	ENSLACP00000002907	Neuropilin; Belongs to the neuropilin family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.447
NRP1	PDGFC	ENSLACP00000023533	ENSLACP00000023425	Neuropilin; Belongs to the neuropilin family.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.426
NRP1	PDGFRA	ENSLACP00000023533	ENSLACP00000010339	Neuropilin; Belongs to the neuropilin family.	Uncharacterized protein.	0.668
NRP1	PDGFRB	ENSLACP00000023533	ENSLACP00000016550	Neuropilin; Belongs to the neuropilin family.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.642
NRP1	PDGFRL	ENSLACP00000023533	ENSLACP00000003321	Neuropilin; Belongs to the neuropilin family.	Platelet derived growth factor receptor like.	0.650