(53 nodes) Regulation of fibroblast proliferation network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (240 aa)
	CDC73	Cell division cycle 73. (316 aa)
	TRIM32	Tripartite motif containing 32. (647 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	LIG4	DNA ligase. (911 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (322 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
	FN1	Fibronectin 1. (2295 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
	BAX	Uncharacterized protein. (223 aa)
	CD248	CD248 molecule, endosialin a. (550 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	E2F1	E2F transcription factor 1. (411 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	FOSL2	FOS like 2, AP-1 transcription factor subunit. (332 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	SIRT6	Sirtuin 6. (375 aa)
	PARP10	Poly [ADP-ribose] polymerase. (922 aa)
	MORC3	MORC family CW-type zinc finger 3. (831 aa)
	FBRS	Uncharacterized protein. (1187 aa)
	NLRC3	NLR family CARD domain containing 3. (1005 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	WAPL	WAPL cohesin release factor. (1215 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (169 aa)
	B4GALT7	Beta-1,4-galactosyltransferase 7. (323 aa)
	H3ATF5_LATCH	Cdc6_C domain-containing protein. (525 aa)
	LOC102367075	Uncharacterized protein. (138 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	PAWR	Uncharacterized protein. (118 aa)
	LOC102366718	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (327 aa)
	H3B0Y6_LATCH	PRKC, apoptosis, WT1, regulator. (191 aa)
	MED25	Mediator complex subunit 25. (663 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (944 aa)
	GAS6	Uncharacterized protein. (681 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	CD74	CD74 molecule. (279 aa)
	NF1	Neurofibromin 1. (2814 aa)
	MYC	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (412 aa)
	DHX9	DExH-box helicase 9. (1249 aa)
	LOC102353843	Uncharacterized protein. (335 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	PLA2G1B	Phospholipase A(2). (152 aa)
	LOC102359454	Phospholipase A(2). (154 aa)
	H3BG59_LATCH	Uncharacterized protein. (162 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	MED31	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (128 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	PEX2	Peroxisomal biogenesis factor 2. (299 aa)
	FBXO4	F-box protein 4. (348 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	TP53	ENSLACP00000007049	ENSLACP00000015915	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.780
CDK4	CDK6	ENSLACP00000005801	ENSLACP00000004612	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.903
CDK4	E2F1	ENSLACP00000005801	ENSLACP00000007825	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	E2F transcription factor 1.	0.678
CDK4	FBRS	ENSLACP00000005801	ENSLACP00000010371	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.508
CDK4	H3ATF5_LATCH	ENSLACP00000005801	ENSLACP00000012926	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Cdc6_C domain-containing protein.	0.845
CDK4	LOC102366718	ENSLACP00000005801	ENSLACP00000014188	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.902
CDK4	TP53	ENSLACP00000005801	ENSLACP00000015915	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.608
CDK4	WAPL	ENSLACP00000005801	ENSLACP00000011032	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	WAPL cohesin release factor.	0.465
CDK6	CDK4	ENSLACP00000004612	ENSLACP00000005801	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.903
CDK6	E2F1	ENSLACP00000004612	ENSLACP00000007825	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	E2F transcription factor 1.	0.612
CDK6	FBRS	ENSLACP00000004612	ENSLACP00000010371	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.508
CDK6	H3ATF5_LATCH	ENSLACP00000004612	ENSLACP00000012926	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cdc6_C domain-containing protein.	0.845
CDK6	LOC102366718	ENSLACP00000004612	ENSLACP00000014188	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.902
CDK6	TP53	ENSLACP00000004612	ENSLACP00000015915	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.667
CDK6	WAPL	ENSLACP00000004612	ENSLACP00000011032	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	WAPL cohesin release factor.	0.465
E2F1	CDK4	ENSLACP00000007825	ENSLACP00000005801	E2F transcription factor 1.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.678
E2F1	CDK6	ENSLACP00000007825	ENSLACP00000004612	E2F transcription factor 1.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.612
E2F1	H3ATF5_LATCH	ENSLACP00000007825	ENSLACP00000012926	E2F transcription factor 1.	Cdc6_C domain-containing protein.	0.694
E2F1	LOC102366718	ENSLACP00000007825	ENSLACP00000014188	E2F transcription factor 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.612
E2F1	MYC	ENSLACP00000007825	ENSLACP00000019515	E2F transcription factor 1.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.651