(25 nodes) Positive regulation of receptor-mediated endocytosis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DTNBP1	Dystrobrevin binding protein 1. (355 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	H3BE69_LATCH	PID domain-containing protein. (136 aa)
	SCYL2	SCY1 like pseudokinase 2. (939 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family. (644 aa)
	H3B4C9_LATCH	PDZ domain-containing protein. (105 aa)
	DAB2	DAB adaptor protein 2. (745 aa)
	CD63	Tetraspanin. (270 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (303 aa)
	CLUL1	Clusterin; Belongs to the clusterin family. (466 aa)
	HIP1	Huntingtin interacting protein 1. (1004 aa)
	CLU	Clusterin; Belongs to the clusterin family. (461 aa)
	VTN	Vitronectin b. (492 aa)
	MAGI2	Uncharacterized protein. (397 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1b. (316 aa)
	H2ZSB4_LATCH	AAA_lid_3 domain-containing protein. (125 aa)
	H3A0S5_LATCH	Uncharacterized protein. (547 aa)
	FMR1	Fragile X mental retardation 1. (627 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	SYNJ1	Synaptojanin 1. (1563 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (672 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (367 aa)
	TBC1D5	TBC1 domain family member 5. (335 aa)
	PICK1	Protein interacting with PRKCA 1. (409 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLU	VTN	ENSLACP00000022883	ENSLACP00000021946	Clusterin; Belongs to the clusterin family.	Vitronectin b.	0.534
CLUL1	VTN	ENSLACP00000018267	ENSLACP00000021946	Clusterin; Belongs to the clusterin family.	Vitronectin b.	0.713
DAB2	LDLRAP1	ENSLACP00000014800	ENSLACP00000013427	DAB adaptor protein 2.	Low density lipoprotein receptor adaptor protein 1b.	0.473
DAB2	SGIP1	ENSLACP00000014800	ENSLACP00000014967	DAB adaptor protein 2.	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.580
H3B4C9_LATCH	MAGI2	ENSLACP00000016750	ENSLACP00000014418	PDZ domain-containing protein.	Uncharacterized protein.	0.900
H3BE69_LATCH	LDLRAP1	ENSLACP00000020190	ENSLACP00000013427	PID domain-containing protein.	Low density lipoprotein receptor adaptor protein 1b.	0.473
H3BE69_LATCH	SGIP1	ENSLACP00000020190	ENSLACP00000014967	PID domain-containing protein.	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.580
HIP1	SGIP1	ENSLACP00000021547	ENSLACP00000014967	Huntingtin interacting protein 1.	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.581
LDLRAP1	DAB2	ENSLACP00000013427	ENSLACP00000014800	Low density lipoprotein receptor adaptor protein 1b.	DAB adaptor protein 2.	0.473
LDLRAP1	H3BE69_LATCH	ENSLACP00000013427	ENSLACP00000020190	Low density lipoprotein receptor adaptor protein 1b.	PID domain-containing protein.	0.473
LDLRAP1	PCSK9	ENSLACP00000013427	ENSLACP00000011043	Low density lipoprotein receptor adaptor protein 1b.	Proprotein convertase subtilisin/kexin type 9.	0.537
LDLRAP1	SGIP1	ENSLACP00000013427	ENSLACP00000014967	Low density lipoprotein receptor adaptor protein 1b.	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.528
MAGI2	H3B4C9_LATCH	ENSLACP00000014418	ENSLACP00000016750	Uncharacterized protein.	PDZ domain-containing protein.	0.900
PCSK9	LDLRAP1	ENSLACP00000011043	ENSLACP00000013427	Proprotein convertase subtilisin/kexin type 9.	Low density lipoprotein receptor adaptor protein 1b.	0.537
SERPINE1	VTN	ENSLACP00000006192	ENSLACP00000021946	Serpin family E member 1; Belongs to the serpin family.	Vitronectin b.	0.997
SGIP1	DAB2	ENSLACP00000014967	ENSLACP00000014800	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	DAB adaptor protein 2.	0.580
SGIP1	H3BE69_LATCH	ENSLACP00000014967	ENSLACP00000020190	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	PID domain-containing protein.	0.580
SGIP1	HIP1	ENSLACP00000014967	ENSLACP00000021547	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	Huntingtin interacting protein 1.	0.581
SGIP1	LDLRAP1	ENSLACP00000014967	ENSLACP00000013427	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	Low density lipoprotein receptor adaptor protein 1b.	0.528
VTN	CLU	ENSLACP00000021946	ENSLACP00000022883	Vitronectin b.	Clusterin; Belongs to the clusterin family.	0.534