(12 nodes) Retinoic acid receptor signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102364341	Uncharacterized protein. (271 aa)
	RARA	Retinoic acid receptor alpha. (505 aa)
	RARB	NR LBD domain-containing protein. (299 aa)
	RXRB	Retinoid X receptor beta. (453 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	SNW1	SNW domain containing 1. (536 aa)
	PTF1A	Pancreas associated transcription factor 1a. (266 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
	RARG	Retinoic acid receptor gamma. (389 aa)
	RXRA	Retinoid X receptor alpha. (363 aa)
	LOC102351060	Uncharacterized protein. (459 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	LOC102364341	ENSLACP00000014901	ENSLACP00000001390	CRK like proto-oncogene, adaptor protein.	Uncharacterized protein.	0.902
CYP26B1	RARB	ENSLACP00000017241	ENSLACP00000007216	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	NR LBD domain-containing protein.	0.438
LOC102351060	PPARG	ENSLACP00000022538	ENSLACP00000010456	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.974
LOC102351060	RARA	ENSLACP00000022538	ENSLACP00000007011	Uncharacterized protein.	Retinoic acid receptor alpha.	0.727
LOC102351060	RARB	ENSLACP00000022538	ENSLACP00000007216	Uncharacterized protein.	NR LBD domain-containing protein.	0.727
LOC102351060	RARG	ENSLACP00000022538	ENSLACP00000018412	Uncharacterized protein.	Retinoic acid receptor gamma.	0.727
LOC102351060	RXRB	ENSLACP00000022538	ENSLACP00000007909	Uncharacterized protein.	Retinoid X receptor beta.	0.901
LOC102364341	CRKL	ENSLACP00000001390	ENSLACP00000014901	Uncharacterized protein.	CRK like proto-oncogene, adaptor protein.	0.902
PPARG	LOC102351060	ENSLACP00000010456	ENSLACP00000022538	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Uncharacterized protein.	0.974
PPARG	RXRA	ENSLACP00000010456	ENSLACP00000021356	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Retinoid X receptor alpha.	0.878
PPARG	RXRB	ENSLACP00000010456	ENSLACP00000007909	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Retinoid X receptor beta.	0.970
RARA	LOC102351060	ENSLACP00000007011	ENSLACP00000022538	Retinoic acid receptor alpha.	Uncharacterized protein.	0.727
RARA	RXRA	ENSLACP00000007011	ENSLACP00000021356	Retinoic acid receptor alpha.	Retinoid X receptor alpha.	0.727
RARA	RXRB	ENSLACP00000007011	ENSLACP00000007909	Retinoic acid receptor alpha.	Retinoid X receptor beta.	0.747
RARB	CYP26B1	ENSLACP00000007216	ENSLACP00000017241	NR LBD domain-containing protein.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.438
RARB	LOC102351060	ENSLACP00000007216	ENSLACP00000022538	NR LBD domain-containing protein.	Uncharacterized protein.	0.727
RARB	RXRA	ENSLACP00000007216	ENSLACP00000021356	NR LBD domain-containing protein.	Retinoid X receptor alpha.	0.727
RARB	RXRB	ENSLACP00000007216	ENSLACP00000007909	NR LBD domain-containing protein.	Retinoid X receptor beta.	0.752
RARG	LOC102351060	ENSLACP00000018412	ENSLACP00000022538	Retinoic acid receptor gamma.	Uncharacterized protein.	0.727
RARG	RXRA	ENSLACP00000018412	ENSLACP00000021356	Retinoic acid receptor gamma.	Retinoid X receptor alpha.	0.727