STRINGSTRING
TIMELESS TIMELESS LOC102352539 LOC102352539 OPN4 OPN4 LOC102355441 LOC102355441 SIRT1 SIRT1 CSNK1E CSNK1E ENPP2 ENPP2 LOC102347106 LOC102347106 SIRT6 SIRT6 PLD2-2 PLD2-2 DTL DTL ID1 ID1 ID2 ID2 ID4 ID4 NFIL3 NFIL3 KIAA2013 KIAA2013 H3AC70_LATCH H3AC70_LATCH ENOX1 ENOX1 KDM8 KDM8 RORB RORB DBP DBP LOC102351204 LOC102351204 PRKAA2 PRKAA2 NAGLU NAGLU NRIP1 NRIP1 EGR1 EGR1 FAM155A-2 FAM155A-2 GAS2 GAS2 INHBA INHBA ARNTL ARNTL CRTC1 CRTC1 PER1 PER1 NAMPT NAMPT TNFAIP6 TNFAIP6 BTBD9 BTBD9 ATF4 ATF4 PRKAA1 PRKAA1 NCOR1 NCOR1 H3A246_LATCH H3A246_LATCH ATG7 ATG7 LOC102352528 LOC102352528 NR1D2 NR1D2 MYCBP2 MYCBP2 AHR AHR NTRK2 NTRK2 H2ZZY5_LATCH H2ZZY5_LATCH MTTP MTTP H2ZZF1_LATCH H2ZZF1_LATCH SUV39H2 SUV39H2 MAPK9 MAPK9 BHLHE40 BHLHE40 FZD4 FZD4 PTX3 PTX3 NGFR NGFR PIWIL2 PIWIL2 HTR7 HTR7 LOC102355825 LOC102355825 NONO NONO CRY1 CRY1 SLIT3 SLIT3 SYNPR-2 SYNPR-2 CREBBP CREBBP ZPBP2 ZPBP2 PER2 PER2 THRAP3 THRAP3 PER3 PER3 PROK2 PROK2 FBXW7 FBXW7 CDK1 CDK1 MDK MDK H3BH94_LATCH H3BH94_LATCH MYBBP1A MYBBP1A MAPK8 MAPK8 GPR176 GPR176 CRY2 CRY2 DRD2 DRD2 LOC102365013 LOC102365013 NDUFA9 NDUFA9 TOP1 TOP1 SETX SETX AXL AXL HNF1A HNF1A RORC RORC DHX9 DHX9 DDB1 DDB1 ATOH7 ATOH7 RORA RORA LOC102349421 LOC102349421 MTOR MTOR LOC102362765 LOC102362765 GPR149 GPR149 PASD1 PASD1 H3B8U3_LATCH H3B8U3_LATCH CREB1 CREB1 NOCT NOCT NTRK1 NTRK1 ROCK2 ROCK2 NUDT12 NUDT12 AANAT AANAT PPP1CC PPP1CC GPR157 GPR157 NFYA NFYA PTN PTN RACK1 RACK1 DDX5 DDX5 LOC102355850 LOC102355850 LOC102345440 LOC102345440 SFPQ SFPQ DRD4 DRD4 NCOR2 NCOR2 METTL3 METTL3 PPARGC1A PPARGC1A TP53 TP53 CSNK1D CSNK1D EGR2 EGR2 KLF10 KLF10 TRPM2 TRPM2 PAM PAM CLOCK CLOCK BHLHE41 BHLHE41 EGR3 EGR3 HOMER1 HOMER1 LOC102346373 LOC102346373 HLF HLF OGT OGT ENOX2 ENOX2 KDM5A KDM5A RAI1 RAI1 H3AWN2_LATCH H3AWN2_LATCH SGPL1 SGPL1 LGR4 LGR4 CIPC CIPC SP1 SP1 ZNF830 ZNF830 NPAS2 NPAS2 FBXW9 FBXW9 LOC102360171 LOC102360171 NR0B2 NR0B2 GRIN3A GRIN3A LHCGR LHCGR SCAPER SCAPER HES7 HES7 PRMT5 PRMT5 CIART CIART PPARA PPARA SLIT2 SLIT2 PSPC1 PSPC1 PPP1CB PPP1CB H3AQU6_LATCH H3AQU6_LATCH LOC102365364 LOC102365364 HUWE1 HUWE1 CCDC90B CCDC90B H3ANW9_LATCH H3ANW9_LATCH DNM1L DNM1L HDAC3 HDAC3 NR1D1 NR1D1 H3AN57_LATCH H3AN57_LATCH ARNTL2 ARNTL2 LOC102359594 LOC102359594 ID3 ID3 LOC102363520 LOC102363520 ADNP ADNP PPP1CA PPP1CA PPARG PPARG LOC102356424 LOC102356424 MAPK10 MAPK10 ATF5 ATF5 H3AJ81_LATCH H3AJ81_LATCH CDK5 CDK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIMELESSTimeless circadian regulator. (1272 aa)
LOC102352539Uncharacterized protein. (949 aa)
OPN4Opsin 4. (517 aa)
LOC102355441Cocaine- and amphetamine-regulated transcript 3. (119 aa)
SIRT1Sirtuin 1. (729 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (418 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (893 aa)
LOC1023471065-hydroxytryptamine (serotonin) receptor 7b; Belongs to the G-protein coupled receptor 1 family. (398 aa)
SIRT6Sirtuin 6. (375 aa)
PLD2-2Uncharacterized protein. (392 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (748 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (131 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (132 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (468 aa)
KIAA2013KIAA2013. (610 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
ENOX1Ecto-NOX disulfide-thiol exchanger 1. (629 aa)
KDM8Lysine demethylase 8. (407 aa)
RORBRAR related orphan receptor B. (463 aa)
DBPD-box binding PAR bZIP transcription factor. (332 aa)
LOC102351204DUF1053 domain-containing protein. (254 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (614 aa)
NRIP1Nuclear receptor interacting protein 1. (1186 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
FAM155A-2Family with sequence similarity 155 member A. (253 aa)
GAS2Growth arrest specific 2. (322 aa)
INHBAInhibin subunit beta A. (390 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (635 aa)
CRTC1CREB regulated transcription coactivator 1. (615 aa)
PER1Period circadian regulator 1. (1131 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (492 aa)
TNFAIP6TNF alpha induced protein 6. (279 aa)
BTBD9BTB domain containing 9. (536 aa)
ATF4Activating transcription factor 4. (374 aa)
PRKAA1Non-specific serine/threonine protein kinase. (552 aa)
NCOR1Nuclear receptor corepressor 1. (2480 aa)
H3A246_LATCHUncharacterized protein. (920 aa)
ATG7Autophagy related 7. (593 aa)
LOC102352528G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (592 aa)
MYCBP2MYC binding protein 2. (5051 aa)
AHRAryl hydrocarbon receptor 1a. (868 aa)
NTRK2Tyrosine-protein kinase receptor. (819 aa)
H2ZZY5_LATCHUncharacterized protein. (548 aa)
MTTPMicrosomal triglyceride transfer protein. (893 aa)
H2ZZF1_LATCHPAS domain-containing protein. (1038 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (480 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BHLHE40Basic helix-loop-helix family, member e40. (327 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
PTX3Uncharacterized protein. (423 aa)
NGFRNerve growth factor receptor. (197 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (954 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LOC102355825Opsin 4xa; Belongs to the G-protein coupled receptor 1 family. (260 aa)
NONONon-POU domain containing octamer binding. (418 aa)
CRY1Cryptochrome circadian regulator 1. (653 aa)
SLIT3Slit guidance ligand 3. (635 aa)
SYNPR-2Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (493 aa)
CREBBPCREB binding protein. (2411 aa)
ZPBP2Ig-like domain-containing protein. (330 aa)
PER2PAS domain-containing protein. (1371 aa)
THRAP3Thyroid hormone receptor associated protein 3. (982 aa)
PER3Period circadian regulator 3. (1317 aa)
PROK2Prokineticin 2. (159 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
MDKMidkine. (141 aa)
H3BH94_LATCHPAS domain-containing protein. (733 aa)
MYBBP1AMYB binding protein 1a. (1272 aa)
MAPK8Mitogen-activated protein kinase. (437 aa)
GPR176G protein-coupled receptor 176. (461 aa)
CRY2Cryptochrome circadian regulator 2. (434 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
LOC102365013Class E basic helix-loop-helix protein 40-like. (327 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (305 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (743 aa)
SETXSenataxin. (2165 aa)
AXLAXL receptor tyrosine kinase. (872 aa)
HNF1AHNF1 homeobox A. (624 aa)
RORCRAR related orphan receptor C. (502 aa)
DHX9DExH-box helicase 9. (1249 aa)
DDB1Damage specific DNA binding protein 1. (1142 aa)
ATOH7Atonal bHLH transcription factor 7. (151 aa)
RORARAR related orphan receptor A. (468 aa)
LOC102349421Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
LOC102362765Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
GPR149G protein-coupled receptor 149. (714 aa)
PASD1Uncharacterized protein. (770 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
CREB1cAMP responsive element binding protein 1. (347 aa)
NOCTNocturnin. (446 aa)
NTRK1Tyrosine-protein kinase receptor. (747 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
NUDT12Nudix hydrolase 12. (460 aa)
AANATAralkylamine N-acetyltransferase. (205 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
GPR157G protein-coupled receptor 157. (333 aa)
NFYANuclear transcription factor Y subunit alpha. (340 aa)
PTNPleiotrophin. (167 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
LOC102355850F-box and leucine-rich repeat protein 3, like. (437 aa)
LOC102345440Nuclear receptor subfamily 1, group D, member 4b. (554 aa)
SFPQSplicing factor proline and glutamine rich. (622 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (382 aa)
NCOR2Nuclear receptor corepressor 2. (2350 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
PPARGC1APPARG coactivator 1 alpha. (783 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
CSNK1DCasein kinase 1 delta. (417 aa)
EGR2Early growth response 2. (433 aa)
KLF10Kruppel like factor 10. (476 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1473 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (960 aa)
CLOCKClock circadian regulator. (846 aa)
BHLHE41Basic helix-loop-helix family member e41. (414 aa)
EGR3Early growth response 3. (384 aa)
HOMER1Homer scaffold protein 1. (367 aa)
LOC102346373Uncharacterized protein. (464 aa)
HLFHLF transcription factor, PAR bZIP family member. (333 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
ENOX2Ecto-NOX disulfide-thiol exchanger 2. (611 aa)
KDM5ALysine demethylase 5A. (1695 aa)
RAI1Retinoic acid induced 1. (1783 aa)
H3AWN2_LATCHCryptochrome circadian regulator 4. (531 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (566 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
CIPCCLOCK interacting pacemaker. (417 aa)
SP1Sp1 transcription factor. (754 aa)
ZNF830zf-C2H2_jaz domain-containing protein. (240 aa)
NPAS2Neuronal PAS domain protein 2. (818 aa)
FBXW9F-box and WD repeat domain containing 9. (465 aa)
LOC102360171Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (426 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (260 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1109 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (593 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1476 aa)
HES7BHLH domain-containing protein. (188 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (658 aa)
CIARTUncharacterized protein. (181 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
PSPC1Paraspeckle component 1. (525 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
H3AQU6_LATCHAC_N domain-containing protein. (191 aa)
LOC102365364Cryptochrome circadian regulator 3a. (616 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4101 aa)
CCDC90BCoiled-coil domain containing 90B. (257 aa)
H3ANW9_LATCHBZIP domain-containing protein. (139 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (778 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
H3AN57_LATCHG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (553 aa)
LOC102359594Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (121 aa)
LOC102363520CCHC-type domain-containing protein. (238 aa)
ADNPActivity dependent neuroprotector homeobox. (1116 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (344 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
LOC102356424Nuclear factor, interleukin 3 regulated, member 6. (352 aa)
MAPK10Mitogen-activated protein kinase 10. (342 aa)
ATF5Activating transcription factor 5. (340 aa)
H3AJ81_LATCHSerine/threonine-protein phosphatase. (349 aa)
CDK5Cyclin dependent kinase 5. (290 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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