(21 nodes) Spleen development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX2-3	NK2 homeobox 3. (334 aa)
	RC3H2	RING-type domain-containing protein. (352 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	PCID2	PCI domain containing 2. (452 aa)
	NKX3-2	NK3 homeobox 2. (282 aa)
	LOC102358239	TRAF3 interacting protein 2-like. (392 aa)
	TCF21	Transcription factor 21. (179 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (906 aa)
	FADD	Fas associated via death domain. (193 aa)
	H3AKR5_LATCH	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (547 aa)
	TRAF3IP2	SEFIR domain-containing protein. (379 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (583 aa)
	CACNB4	Calcium channel, voltage-dependent, beta 4a subunit. (477 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	NKX2-5	NK2 homeobox 5. (296 aa)
	HOXB4	Homeobox domain-containing protein. (247 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	BARX1	BARX homeobox 1. (250 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (451 aa)
	H3BI75_LATCH	Uncharacterized protein. (110 aa)
	M3XHJ5_LATCH	Uncharacterized protein. (158 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARX1	NKX3-2	ENSLACP00000019934	ENSLACP00000004053	BARX homeobox 1.	NK3 homeobox 2.	0.518
CACNB4	PPP2R3C	ENSLACP00000014759	ENSLACP00000020313	Calcium channel, voltage-dependent, beta 4a subunit.	Protein phosphatase 2 regulatory subunit B''gamma.	0.650
FADD	H2ZV40_LATCH	ENSLACP00000009943	ENSLACP00000001261	Fas associated via death domain.	Protein kinase domain-containing protein.	0.994
H2ZV40_LATCH	FADD	ENSLACP00000001261	ENSLACP00000009943	Protein kinase domain-containing protein.	Fas associated via death domain.	0.994
H3BI75_LATCH	RC3H1	ENSLACP00000021596	ENSLACP00000018376	Uncharacterized protein.	Ring finger and CCCH-type domains 1.	0.510
NKX2-5	TCF21	ENSLACP00000016921	ENSLACP00000005654	NK2 homeobox 5.	Transcription factor 21.	0.448
NKX3-2	BARX1	ENSLACP00000004053	ENSLACP00000019934	NK3 homeobox 2.	BARX homeobox 1.	0.518
NKX3-2	TCF21	ENSLACP00000004053	ENSLACP00000005654	NK3 homeobox 2.	Transcription factor 21.	0.478
PPP2R3C	CACNB4	ENSLACP00000020313	ENSLACP00000014759	Protein phosphatase 2 regulatory subunit B''gamma.	Calcium channel, voltage-dependent, beta 4a subunit.	0.650
RC3H1	H3BI75_LATCH	ENSLACP00000018376	ENSLACP00000021596	Ring finger and CCCH-type domains 1.	Uncharacterized protein.	0.510
RC3H1	RC3H2	ENSLACP00000018376	ENSLACP00000000453	Ring finger and CCCH-type domains 1.	RING-type domain-containing protein.	0.514
RC3H2	RC3H1	ENSLACP00000000453	ENSLACP00000018376	RING-type domain-containing protein.	Ring finger and CCCH-type domains 1.	0.514
TCF21	NKX2-5	ENSLACP00000005654	ENSLACP00000016921	Transcription factor 21.	NK2 homeobox 5.	0.448
TCF21	NKX3-2	ENSLACP00000005654	ENSLACP00000004053	Transcription factor 21.	NK3 homeobox 2.	0.478