(42 nodes) Neuron fate commitment network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	GBX1	Gastrulation brain homeobox 1. (331 aa)
	ZNF521	Zinc finger protein 521. (1239 aa)
	FKBP8	Peptidylprolyl isomerase. (443 aa)
	LOC102360373	Fork-head domain-containing protein. (374 aa)
	ATOH1	Atonal bHLH transcription factor 1. (279 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (273 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (258 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	HOXC10	Homeobox C10. (339 aa)
	GSX1	GS homeobox 1. (241 aa)
	H3B9I7_LATCH	BHLH domain-containing protein. (251 aa)
	PAX6	Paired box 6. (463 aa)
	H3B480_LATCH	Uncharacterized protein. (567 aa)
	FEV	FEV transcription factor, ETS family member. (230 aa)
	PTF1A	Pancreas associated transcription factor 1a. (266 aa)
	H3AZE1_LATCH	BHLH domain-containing protein. (209 aa)
	FOXG1	Forkhead box G1. (409 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (313 aa)
	ISL1	ISL LIM homeobox 1. (356 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	NKX2-2	NK2 homeobox 2. (278 aa)
	DLX1	Distal-less homeobox 1. (253 aa)
	DLX2	Distal-less homeobox 2. (278 aa)
	LOC102353790	Uncharacterized protein. (899 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (484 aa)
	FOXN4	Forkhead box N4. (514 aa)
	DBX1	Developing brain homeobox 1. (326 aa)
	ISL2	ISL LIM homeobox 2. (360 aa)
	LOC102355848	Uncharacterized protein. (306 aa)
	LOC102357614	Fork-head domain-containing protein. (345 aa)
	HOXD10	Homeobox D10. (337 aa)
	TBR1	T-box brain transcription factor 1. (673 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (422 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	GSX2	GS homeobox 2. (279 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	PAX6	ENSLACP00000006193	ENSLACP00000017411	Atonal bHLH transcription factor 1.	Paired box 6.	0.443
DBX1	ISL2	ENSLACP00000012830	ENSLACP00000012674	Developing brain homeobox 1.	ISL LIM homeobox 2.	0.429
DBX1	OLIG2	ENSLACP00000012830	ENSLACP00000006181	Developing brain homeobox 1.	Oligodendrocyte transcription factor 2.	0.533
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	DLL4	ENSLACP00000009351	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	NOTCH3	ENSLACP00000009351	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL4	ENSLACP00000008690	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938
DLL3	LOC102353790	ENSLACP00000008690	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.973
DLL3	NOTCH3	ENSLACP00000008690	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.973
DLL4	DLL1	ENSLACP00000013765	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL4	DLL3	ENSLACP00000013765	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938
DLL4	FOXN4	ENSLACP00000013765	ENSLACP00000013000	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Forkhead box N4.	0.598
DLL4	JAG2	ENSLACP00000013765	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.591
DLL4	LOC102353790	ENSLACP00000013765	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.981
DLL4	NOTCH3	ENSLACP00000013765	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.981
DLX1	DLX2	ENSLACP00000002197	ENSLACP00000001538	Distal-less homeobox 1.	Distal-less homeobox 2.	0.798
DLX2	DLX1	ENSLACP00000001538	ENSLACP00000002197	Distal-less homeobox 2.	Distal-less homeobox 1.	0.798