(26 nodes) Astrocyte differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (477 aa)
	PAX6	Paired box 6. (463 aa)
	LAMB2	Laminin subunit beta 2. (1781 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (449 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (718 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1. (769 aa)
	C1QA	Complement C1q A chain. (241 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	H3A4P0_LATCH	Ig-like domain-containing protein. (174 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1311 aa)
	GCM1	Glial cells missing transcription factor 1. (443 aa)
	EOMES	Eomesodermin. (419 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	PLPP3	Phospholipid phosphatase 3. (285 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	CNTF	Uncharacterized protein. (206 aa)
	TSPAN2	Tetraspanin. (221 aa)
	PLP1	Proteolipid protein 1. (245 aa)
	NF1	Neurofibromin 1. (2814 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
APP	GFAP	ENSLACP00000001643	ENSLACP00000015185	Amyloid beta precursor protein.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.560
APP	PSEN1	ENSLACP00000001643	ENSLACP00000012775	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
CNTF	GFAP	ENSLACP00000022760	ENSLACP00000015185	Uncharacterized protein.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.468
CNTF	SMO	ENSLACP00000022760	ENSLACP00000002758	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.430
CNTF	STAT3	ENSLACP00000022760	ENSLACP00000013656	Uncharacterized protein.	Signal transducer and activator of transcription.	0.554
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
EOMES	PAX6	ENSLACP00000003120	ENSLACP00000017411	Eomesodermin.	Paired box 6.	0.493
GFAP	APP	ENSLACP00000015185	ENSLACP00000001643	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Amyloid beta precursor protein.	0.560
GFAP	CNTF	ENSLACP00000015185	ENSLACP00000022760	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.468
GFAP	PAX6	ENSLACP00000015185	ENSLACP00000017411	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Paired box 6.	0.684
GFAP	PLP1	ENSLACP00000015185	ENSLACP00000020328	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Proteolipid protein 1.	0.558
GFAP	PSEN1	ENSLACP00000015185	ENSLACP00000012775	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.455
GFAP	STAT3	ENSLACP00000015185	ENSLACP00000013656	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Signal transducer and activator of transcription.	0.496
H3A4P0_LATCH	ROR1	ENSLACP00000004611	ENSLACP00000010024	Ig-like domain-containing protein.	Receptor tyrosine kinase like orphan receptor 1.	0.900
H3A4P0_LATCH	ROR2	ENSLACP00000004611	ENSLACP00000001497	Ig-like domain-containing protein.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.539
NF1	PAX6	ENSLACP00000019331	ENSLACP00000017411	Neurofibromin 1.	Paired box 6.	0.699
PAX6	EOMES	ENSLACP00000017411	ENSLACP00000003120	Paired box 6.	Eomesodermin.	0.493