(22 nodes) Brain morphogenesis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSX2	GS homeobox 2. (279 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	SLC4A10	Anion exchange protein. (1097 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1187 aa)
	H3A6Z7_LATCH	Bardet-Biedl syndrome 1. (596 aa)
	FBXW11	F-box and WD repeat domain containing 11. (529 aa)
	GDF7	Growth differentiation factor 7. (416 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	LOC102367330	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (616 aa)
	HESX1	HESX homeobox 1. (185 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (660 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (724 aa)
	NF1	Neurofibromin 1. (2814 aa)
	OTX1	Orthodenticle homeobox 1. (339 aa)
	ZNF335	Zinc finger protein 335. (1379 aa)
	FANCD2	FA complementation group D2. (1462 aa)
	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS2	BBS4	ENSLACP00000017026	ENSLACP00000002102	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.998
BBS2	H3A6Z7_LATCH	ENSLACP00000017026	ENSLACP00000005418	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 1.	0.998
BBS2	MKKS	ENSLACP00000017026	ENSLACP00000006659	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.427
BBS2	SMO	ENSLACP00000017026	ENSLACP00000002758	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.705
BBS4	BBS2	ENSLACP00000002102	ENSLACP00000017026	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.998
BBS4	H3A6Z7_LATCH	ENSLACP00000002102	ENSLACP00000005418	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 1.	0.998
BBS4	SMO	ENSLACP00000002102	ENSLACP00000002758	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.692
FGF8	SMO	ENSLACP00000007843	ENSLACP00000002758	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.534
FGF8	SOS1	ENSLACP00000007843	ENSLACP00000004382	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.423
H3A6Z7_LATCH	BBS2	ENSLACP00000005418	ENSLACP00000017026	Bardet-Biedl syndrome 1.	Bardet-Biedl syndrome 2 protein homolog.	0.998
H3A6Z7_LATCH	BBS4	ENSLACP00000005418	ENSLACP00000002102	Bardet-Biedl syndrome 1.	Bardet-Biedl syndrome 4.	0.998
H3A6Z7_LATCH	MKKS	ENSLACP00000005418	ENSLACP00000006659	Bardet-Biedl syndrome 1.	McKusick-Kaufman syndrome.	0.444
H3A6Z7_LATCH	SMO	ENSLACP00000005418	ENSLACP00000002758	Bardet-Biedl syndrome 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.812
MKKS	BBS2	ENSLACP00000006659	ENSLACP00000017026	McKusick-Kaufman syndrome.	Bardet-Biedl syndrome 2 protein homolog.	0.427
MKKS	H3A6Z7_LATCH	ENSLACP00000006659	ENSLACP00000005418	McKusick-Kaufman syndrome.	Bardet-Biedl syndrome 1.	0.444
NF1	SOS1	ENSLACP00000019331	ENSLACP00000004382	Neurofibromin 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.576
PAFAH1B1	SHANK3	ENSLACP00000020703	ENSLACP00000004784	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.	SH3 and multiple ankyrin repeat domains 3.	0.470
SHANK3	PAFAH1B1	ENSLACP00000004784	ENSLACP00000020703	SH3 and multiple ankyrin repeat domains 3.	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.	0.470
SMO	BBS2	ENSLACP00000002758	ENSLACP00000017026	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Bardet-Biedl syndrome 2 protein homolog.	0.705
SMO	BBS4	ENSLACP00000002758	ENSLACP00000002102	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Bardet-Biedl syndrome 4.	0.692