STRINGSTRING
TGFB2 TGFB2 SFRP2 SFRP2 SEMA4G SEMA4G TBX3 TBX3 GDNF GDNF GREM1 GREM1 XRCC5 XRCC5 FOXC1 FOXC1 GPM6A GPM6A GBX2 GBX2 EDNRA EDNRA WNT7A WNT7A SEMA3D SEMA3D GSC GSC FN1 FN1 SEMA3F SEMA3F SOX18 SOX18 PHOX2B PHOX2B SOX10 SOX10 RET RET MSX1 MSX1 LOC102366847 LOC102366847 KIT KIT SEMA4D SEMA4D SEMA6C SEMA6C SEMA6B SEMA6B PTPRC PTPRC EOMES EOMES GATA6 GATA6 SMO SMO SEMA4C SEMA4C H2ZYB6_LATCH H2ZYB6_LATCH HTR2B HTR2B BBS12 BBS12 JAG1 JAG1 LOC102355203 LOC102355203 OTUD5 OTUD5 H2ZSG0_LATCH H2ZSG0_LATCH LOC102367223 LOC102367223 SEMA6D SEMA6D RDH10 RDH10 NRP1 NRP1 METTL5 METTL5 TP63 TP63 LOC102366586 LOC102366586 LOC102358988 LOC102358988 SEMA4B SEMA4B SOX9 SOX9 LRP6 LRP6 H3BF50_LATCH H3BF50_LATCH HNF1A HNF1A BATF BATF LOC102365809 LOC102365809 H3BD82_LATCH H3BD82_LATCH PHACTR4 PHACTR4 ANXA6 ANXA6 LOC102352268 LOC102352268 CDX2 CDX2 NELFB NELFB FAM172A FAM172A SEMA6A SEMA6A SOX8 SOX8 EDN1 EDN1 SEMA3B SEMA3B LOC102361472 LOC102361472 SEMA3E SEMA3E H3B6V5_LATCH H3B6V5_LATCH TBX2 TBX2 H3B672_LATCH H3B672_LATCH SOX17 SOX17 CTNNB1 CTNNB1 H3B5C9_LATCH H3B5C9_LATCH HOXB4 HOXB4 NOLC1 NOLC1 SEMA4F SEMA4F SRF SRF H3B2Y5_LATCH H3B2Y5_LATCH ERCC2 ERCC2 MYOCD MYOCD TP53 TP53 SEMA3A SEMA3A SEMA4A SEMA4A NRP2 NRP2 FOXC2 FOXC2 SH2B3 SH2B3 EDNRB EDNRB ALCAM ALCAM FGF19 FGF19 H3AY29_LATCH H3AY29_LATCH SHC4 SHC4 PHF5A PHF5A KLHL12 KLHL12 FBXL17 FBXL17 PEF1 PEF1 PWWP2A PWWP2A KBTBD8 KBTBD8 HESX1 HESX1 H3ARL7_LATCH H3ARL7_LATCH PSMD11 PSMD11 ACVR1 ACVR1 LOC102366200 LOC102366200 FOXO4 FOXO4 UFL1 UFL1 HOXD4 HOXD4 FOXS1 FOXS1 SEMA3C SEMA3C SMAD4 SMAD4 JARID2 JARID2 MEOX1 MEOX1 TAPT1 TAPT1 PDCD6 PDCD6 LOC102358221 LOC102358221 SETD2 SETD2 HAND2 HAND2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (789 aa)
TBX3T-box transcription factor 3. (713 aa)
GDNFGlial cell derived neurotrophic factor. (222 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
XRCC5X-ray repair cross complementing 5. (606 aa)
FOXC1Forkhead box C1. (471 aa)
GPM6AGlycoprotein M6A. (298 aa)
GBX2Gastrulation brain homeobox 2. (344 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (715 aa)
GSCGoosecoid homeobox. (243 aa)
FN1Fibronectin 1. (2295 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (772 aa)
SOX18SRY-box transcription factor 18. (427 aa)
PHOX2BPaired like homeobox 2B. (287 aa)
SOX10SRY-box transcription factor 10. (451 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
MSX1Msh homeobox 1. (256 aa)
LOC102366847Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (1059 aa)
SEMA6BSema domain-containing protein; Belongs to the semaphorin family. (911 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (830 aa)
EOMESEomesodermin. (419 aa)
GATA6GATA binding protein 6. (503 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (794 aa)
H2ZYB6_LATCHUncharacterized protein. (324 aa)
HTR2B5-hydroxytryptamine receptor 2B. (474 aa)
BBS12Bardet-Biedl syndrome 12. (709 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
LOC102355203Na_H_Exchanger domain-containing protein. (161 aa)
OTUD5OTU deubiquitinase 5. (534 aa)
H2ZSG0_LATCHSema domain-containing protein. (212 aa)
LOC102367223TGF_BETA_2 domain-containing protein. (144 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1076 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (348 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (928 aa)
METTL5Methyltransferase like 5. (215 aa)
TP63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
LOC102366586Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (825 aa)
SOX9SRY-box transcription factor 9. (475 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
H3BF50_LATCHUncharacterized protein; Belongs to the semaphorin family. (733 aa)
HNF1AHNF1 homeobox A. (624 aa)
BATFBasic leucine zipper ATF-like transcription factor. (119 aa)
LOC102365809Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
H3BD82_LATCHHelicase ATP-binding domain-containing protein. (1243 aa)
PHACTR4Phosphatase and actin regulator. (702 aa)
ANXA6Annexin. (662 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
CDX2Caudal type homeobox 2. (258 aa)
NELFBNegative elongation factor complex member B. (577 aa)
FAM172AFamily with sequence similarity 172 member A. (425 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1020 aa)
SOX8SRY-box transcription factor 8. (477 aa)
EDN1Endothelin 1. (216 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (767 aa)
LOC102361472Si:dkey-49n23.1; Belongs to the semaphorin family. (750 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (739 aa)
H3B6V5_LATCHSema domain-containing protein; Belongs to the semaphorin family. (329 aa)
TBX2T-box transcription factor 2. (689 aa)
H3B672_LATCHUncharacterized protein; Belongs to the semaphorin family. (507 aa)
SOX17SRY-box transcription factor 17. (381 aa)
CTNNB1Catenin beta 1. (781 aa)
H3B5C9_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
HOXB4Homeobox domain-containing protein. (247 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (954 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (650 aa)
SRFSerum response factor. (520 aa)
H3B2Y5_LATCHTGF_BETA_2 domain-containing protein. (189 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (611 aa)
MYOCDMyocardin. (963 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (635 aa)
SEMA4ASema domain-containing protein; Belongs to the semaphorin family. (758 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (929 aa)
FOXC2Forkhead box C2. (469 aa)
SH2B3SH2B adaptor protein 3. (583 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
ALCAMActivated leukocyte cell adhesion molecule. (530 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
H3AY29_LATCHUncharacterized protein. (534 aa)
SHC4SHC adaptor protein 4. (617 aa)
PHF5APHD finger protein 5A. (93 aa)
KLHL12Kelch like family member 12. (564 aa)
FBXL17F-box and leucine rich repeat protein 17. (316 aa)
PEF1Penta-EF-hand domain containing 1. (263 aa)
PWWP2APWWP domain containing 2A. (843 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
HESX1HESX homeobox 1. (185 aa)
H3ARL7_LATCHFork-head domain-containing protein. (195 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
LOC102366200Uncharacterized protein; Belongs to the semaphorin family. (627 aa)
FOXO4Forkhead box O4. (554 aa)
UFL1UFM1 specific ligase 1. (792 aa)
HOXD4Homeobox D4a. (251 aa)
FOXS1Fork-head domain-containing protein. (155 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (550 aa)
SMAD4MH2 domain-containing protein. (412 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (906 aa)
MEOX1Mesenchyme homeobox 1. (241 aa)
TAPT1Transmembrane anterior posterior transformation 1. (597 aa)
PDCD6Programmed cell death 6. (121 aa)
LOC102358221G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2541 aa)
HAND2Heart and neural crest derivatives expressed 2. (210 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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