STRINGSTRING
USP45 USP45 H3ARD8_LATCH H3ARD8_LATCH INAVA INAVA BMP6 BMP6 SLC11A2 SLC11A2 LRRC45 LRRC45 LOC102350991 LOC102350991 ACER1 ACER1 STK11 STK11 TJP2 TJP2 WFS1 WFS1 ACACB ACACB SCNN1G SCNN1G IRX3 IRX3 ZNF830 ZNF830 LOC102351332 LOC102351332 STAT3 STAT3 SCNN1B SCNN1B KDF1 KDF1 SQSTM1 SQSTM1 ERCC6 ERCC6 NXNL2 NXNL2 VSIG1 VSIG1 MFSD2A MFSD2A SLC40A1 SLC40A1 HOMER1 HOMER1 RHO RHO SGIP1 SGIP1 MET MET MRAP2 MRAP2 TRPM2 TRPM2 PBLD PBLD SASH3 SASH3 PPARGC1A PPARGC1A TJP3 TJP3 CDHR1 CDHR1 SRF SRF RP1 RP1 SNX10 SNX10 PM20D1 PM20D1 LOC102345440 LOC102345440 BBS2 BBS2 CTNNB1 CTNNB1 CYP26B1 CYP26B1 NANOS1 NANOS1 CLDN5 CLDN5 CROCC CROCC CLDN1 CLDN1 PIK3CA PIK3CA NCDN NCDN USH1C USH1C VPS54 VPS54 ABCC8 ABCC8 LOC102347432 LOC102347432 STMN1 STMN1 FGF2 FGF2 TNS2 TNS2 NXNL1 NXNL1 HOXA13 HOXA13 LOC102356063 LOC102356063 LOC102354477 LOC102354477 HOMER2 HOMER2 LRRK1 LRRK1 TGFB1 TGFB1 ACACA ACACA DRD2 DRD2 TLR9 TLR9 TJP1 TJP1 CD34 CD34 MLXIPL MLXIPL MKS1 MKS1 CRB2 CRB2 H3BIC4_LATCH H3BIC4_LATCH NPHP4 NPHP4 IL18 IL18 MBP MBP LOC102356247 LOC102356247 EXT2 EXT2 DRAM2 DRAM2 TP53INP2 TP53INP2 TP63 TP63 LCA5 LCA5 M3XL44_LATCH M3XL44_LATCH M3XLI6_LATCH M3XLI6_LATCH USH1G USH1G NOX4 NOX4 ADRB1 ADRB1 ANKRD11 ANKRD11 MTF1 MTF1 KDR KDR NR1D1 NR1D1 FLCN FLCN VSTM4 VSTM4 H3AKR5_LATCH H3AKR5_LATCH GATA1 GATA1 ADGRV1 ADGRV1 LOC102367411 LOC102367411 LOC102366915 LOC102366915 H3AIG1_LATCH H3AIG1_LATCH IQCB1 IQCB1 DLL1 DLL1 STRAP STRAP TNFSF11 TNFSF11 SIRT1 SIRT1 SLC11A1 SLC11A1 DLL3 DLL3 LEPR LEPR HCRT HCRT FH FH H3AF25_LATCH H3AF25_LATCH H3AEK5_LATCH H3AEK5_LATCH TPP1 TPP1 AQP4 AQP4 LOC102366536 LOC102366536 H3ADL8_LATCH H3ADL8_LATCH DBH DBH BAX BAX ILDR2 ILDR2 RP1L1 RP1L1 CRB1 CRB1 LOC102362617 LOC102362617 SPATA7 SPATA7 MKKS MKKS CTSH CTSH H3A9H6_LATCH H3A9H6_LATCH TSKU TSKU LOC102354655 LOC102354655 BSG BSG LOC102359111 LOC102359111 PRDM14 PRDM14 ANKRD12 ANKRD12 H3A6Z7_LATCH H3A6Z7_LATCH METRNL METRNL CCDC66 CCDC66 RB1 RB1 H3A6P6_LATCH H3A6P6_LATCH CRTC1 CRTC1 CXADR CXADR WNK3 WNK3 H3A619_LATCH H3A619_LATCH BTBD9 BTBD9 H3A4S8_LATCH H3A4S8_LATCH STARD7 STARD7 H3A478_LATCH H3A478_LATCH WWTR1-2 WWTR1-2 ADRB2 ADRB2 PRKAA1 PRKAA1 YAP1 YAP1 NAPEPLD NAPEPLD NR1D2 NR1D2 TRAF6 TRAF6 CFTR CFTR AKAP11 AKAP11 LSR LSR AMPD2 AMPD2 ADRB3 ADRB3 EPAS1 EPAS1 SMO SMO CLN8 CLN8 ELOVL1 ELOVL1 TRIM32 TRIM32 LOC102367486 LOC102367486 BBS4 BBS4 LOC102357052 LOC102357052 BBS10 BBS10 NKIRAS1 NKIRAS1 ACP5 ACP5 KLHL10 KLHL10 H2ZWA4_LATCH H2ZWA4_LATCH TRPV4 TRPV4 RRP8 RRP8 BBS12 BBS12 LOC102345119 LOC102345119 CLRN1 CLRN1 UGCG UGCG H2ZTZ4_LATCH H2ZTZ4_LATCH OMA1 OMA1 H2ZTV4_LATCH H2ZTV4_LATCH CRACD CRACD CRTC3 CRTC3 H2ZT48_LATCH H2ZT48_LATCH CCN2 CCN2 ITGB6 ITGB6 WWTR1 WWTR1 H2ZRN8_LATCH H2ZRN8_LATCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USP45Ubiquitinyl hydrolase 1. (823 aa)
H3ARD8_LATCHUncharacterized protein. (2003 aa)
INAVAInnate immunity activator. (599 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
SLC11A2Solute carrier family 11 member 2. (502 aa)
LRRC45Leucine rich repeat containing 45. (679 aa)
LOC102350991Uncharacterized protein. (1471 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (272 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
TJP2Tight junction protein 2a (zona occludens 2). (1241 aa)
WFS1Wolframin ER transmembrane glycoprotein. (876 aa)
ACACBAcetyl-CoA carboxylase beta. (2311 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
IRX3Iroquois homeobox 3. (447 aa)
ZNF830zf-C2H2_jaz domain-containing protein. (240 aa)
LOC102351332Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
KDF1Keratinocyte differentiation factor 1. (380 aa)
SQSTM1Sequestosome 1. (441 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1387 aa)
NXNL2Nucleoredoxin like 2. (157 aa)
VSIG1V-set and immunoglobulin domain containing 1. (339 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (549 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (583 aa)
HOMER1Homer scaffold protein 1. (367 aa)
RHORhodopsin. (355 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family. (644 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1385 aa)
MRAP2Melanocortin 2 receptor accessory protein 2. (163 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1473 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
SASH3SAM and SH3 domain containing 3. (433 aa)
PPARGC1APPARG coactivator 1 alpha. (783 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (859 aa)
CDHR1Cadherin related family member 1. (688 aa)
SRFSerum response factor. (520 aa)
RP1RP1 axonemal microtubule associated. (1901 aa)
SNX10Sorting nexin 10. (203 aa)
PM20D1Peptidase M20 domain containing 1. (517 aa)
LOC102345440Nuclear receptor subfamily 1, group D, member 4b. (554 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (724 aa)
CTNNB1Catenin beta 1. (781 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (213 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
CROCCUncharacterized protein. (1191 aa)
CLDN1Claudin 1. (210 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
NCDNNeurochondrin. (683 aa)
USH1CUSH1 protein network component harmonin. (830 aa)
VPS54VPS54 subunit of GARP complex. (980 aa)
ABCC8ATP binding cassette subfamily C member 8. (1591 aa)
LOC102347432Rhodopsin. (355 aa)
STMN1Stathmin; Belongs to the stathmin family. (144 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
TNS2Tensin 2. (1731 aa)
NXNL1Nucleoredoxin like 1. (221 aa)
HOXA13Homeobox A13b. (295 aa)
LOC102356063Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (554 aa)
LOC102354477Uncharacterized protein. (838 aa)
HOMER2Homer scaffold protein 2. (354 aa)
LRRK1Leucine rich repeat kinase 1. (1987 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
ACACAAcetyl-CoA carboxylase alpha. (2312 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
TLR9Toll-like receptor 9. (1039 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1782 aa)
CD34Uncharacterized protein. (378 aa)
MLXIPLMLX interacting protein like. (862 aa)
MKS1MKS transition zone complex subunit 1. (561 aa)
CRB2Uncharacterized protein. (1473 aa)
H3BIC4_LATCHUncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (328 aa)
NPHP4Nephrocystin 4. (1207 aa)
IL18Uncharacterized protein. (200 aa)
MBPMyelin basic protein. (133 aa)
LOC102356247Uncharacterized protein. (636 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (718 aa)
DRAM2DNA damage regulated autophagy modulator 2. (142 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (232 aa)
TP63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
LCA5Lebercilin LCA5. (743 aa)
M3XL44_LATCHIon_trans domain-containing protein. (134 aa)
M3XLI6_LATCHUncharacterized protein. (426 aa)
USH1GUSH1 protein network component sans. (471 aa)
NOX4NADPH oxidase 4. (541 aa)
ADRB1Adrenoceptor beta 1. (394 aa)
ANKRD11Ankyrin repeat domain 11. (2717 aa)
MTF1Metal regulatory transcription factor 1. (669 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
FLCNFolliculin. (576 aa)
VSTM4V-set and transmembrane domain containing 4. (328 aa)
H3AKR5_LATCHSolute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (547 aa)
GATA1GATA binding protein 1b. (432 aa)
ADGRV1Adhesion G protein-coupled receptor V1. (5847 aa)
LOC102367411Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (334 aa)
LOC102366915Uncharacterized protein. (146 aa)
H3AIG1_LATCHUncharacterized protein. (317 aa)
IQCB1IQ motif containing B1. (601 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
STRAPSerine/threonine kinase receptor associated protein. (329 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
SIRT1Sirtuin 1. (729 aa)
SLC11A1Solute carrier family 11 member 1. (544 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
LEPRLeptin receptor. (1149 aa)
HCRTHypocretin neuropeptide precursor. (104 aa)
FHFumarate hydratase. (491 aa)
H3AF25_LATCHUncharacterized protein. (117 aa)
H3AEK5_LATCHAquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
TPP1Tripeptidyl peptidase 1. (569 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (319 aa)
LOC102366536Phosphoinositide phospholipase C. (1000 aa)
H3ADL8_LATCHANK_REP_REGION domain-containing protein. (405 aa)
DBHDopamine beta-hydroxylase. (617 aa)
BAXUncharacterized protein. (223 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (624 aa)
RP1L1Uncharacterized protein. (1547 aa)
CRB1Crumbs cell polarity complex component 1. (1366 aa)
LOC102362617Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (370 aa)
SPATA7Spermatogenesis associated 7. (398 aa)
MKKSMcKusick-Kaufman syndrome. (575 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
H3A9H6_LATCHFatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (264 aa)
TSKUTsukushi, small leucine rich proteoglycan. (367 aa)
LOC102354655ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (600 aa)
BSGBasigin (Ok blood group). (368 aa)
LOC102359111Nanos homolog 1; Belongs to the nanos family. (224 aa)
PRDM14PR/SET domain 14. (599 aa)
ANKRD12Ankyrin repeat domain 12. (2105 aa)
H3A6Z7_LATCHBardet-Biedl syndrome 1. (596 aa)
METRNLMeteorin like, glial cell differentiation regulator. (288 aa)
CCDC66Coiled-coil domain containing 66. (966 aa)
RB1Uncharacterized protein. (411 aa)
H3A6P6_LATCHANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (593 aa)
CRTC1CREB regulated transcription coactivator 1. (615 aa)
CXADRCXADR Ig-like cell adhesion molecule. (297 aa)
WNK3WNK lysine deficient protein kinase 3. (1769 aa)
H3A619_LATCHANK_REP_REGION domain-containing protein. (363 aa)
BTBD9BTB domain containing 9. (536 aa)
H3A4S8_LATCHUncharacterized protein. (2030 aa)
STARD7StAR related lipid transfer domain containing 7. (360 aa)
H3A478_LATCHPDZ domain-containing protein. (297 aa)
WWTR1-2WW domain-containing protein. (159 aa)
ADRB2Adrenoceptor beta 2. (432 aa)
PRKAA1Non-specific serine/threonine protein kinase. (552 aa)
YAP1Yes associated protein 1. (324 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (263 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (592 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
AKAP11A-kinase anchoring protein 11. (1808 aa)
LSRLipolysis stimulated lipoprotein receptor. (581 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (823 aa)
ADRB3Adrenoceptor beta 3a. (407 aa)
EPAS1Endothelial PAS domain protein 1. (861 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (294 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (302 aa)
TRIM32Tripartite motif containing 32. (647 aa)
LOC102367486Uncharacterized protein. (419 aa)
BBS4Bardet-Biedl syndrome 4. (537 aa)
LOC102357052Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
BBS10Bardet-Biedl syndrome 10. (714 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (191 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (329 aa)
KLHL10Kelch like family member 10. (606 aa)
H2ZWA4_LATCHUncharacterized protein. (297 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
RRP8Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (469 aa)
BBS12Bardet-Biedl syndrome 12. (709 aa)
LOC102345119Uncharacterized protein. (326 aa)
CLRN1Clarin 1. (232 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
H2ZTZ4_LATCHFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (363 aa)
OMA1OMA1 zinc metallopeptidase. (358 aa)
H2ZTV4_LATCHIon_trans domain-containing protein. (103 aa)
CRACDKIAA1211. (986 aa)
CRTC3CREB regulated transcription coactivator 3. (642 aa)
H2ZT48_LATCHUncharacterized protein. (254 aa)
CCN2Cellular communication network factor 2. (344 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (675 aa)
WWTR1WW domain containing transcription regulator 1. (264 aa)
H2ZRN8_LATCHUncharacterized protein. (160 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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