STRINGSTRING
H3B2C8_LATCH H3B2C8_LATCH FGF7 FGF7 NKX2-5 NKX2-5 AR AR BMPR2 BMPR2 COL8A1 COL8A1 PPARD PPARD BAK1 BAK1 NKX2-8 NKX2-8 H3BA30_LATCH H3BA30_LATCH PDX1 PDX1 NF1 NF1 ESRP2 ESRP2 HNF1A HNF1A TGFA TGFA H3BEX6_LATCH H3BEX6_LATCH WNT2B WNT2B TGFB1 TGFB1 CAV3 CAV3 DRD2 DRD2 WDR77 WDR77 IFT52 IFT52 PROK2 PROK2 BMPER BMPER WNT2 WNT2 LGR5 LGR5 H2ZS97_LATCH H2ZS97_LATCH LOC102355548 LOC102355548 CEBPB CEBPB SERPINF1 SERPINF1 SMO SMO MTSS1 MTSS1 PTCH1 PTCH1 NRARP NRARP LOC102355995 LOC102355995 RB1 RB1 PHOX2B PHOX2B CYP7B1 CYP7B1 ST8SIA1 ST8SIA1 H3A8H2_LATCH H3A8H2_LATCH BCL2L2 BCL2L2 BAX BAX FGL1 FGL1 LTA LTA CCN3 CCN3 IGFBP5 IGFBP5 H3AEV1_LATCH H3AEV1_LATCH TGFBR1 TGFBR1 WNT16 WNT16 AREG AREG PRKX PRKX ITGB1BP1 ITGB1BP1 TNFSF11 TNFSF11 IL6 IL6 EAF2 EAF2 HLX HLX VSTM4 VSTM4 EHF EHF H3AM65_LATCH H3AM65_LATCH FLCN FLCN NCSTN NCSTN TEK TEK KDR KDR LOXL4 LOXL4 BAD BAD IFT80 IFT80 EFNB2 EFNB2 LOC102359041 LOC102359041 PSEN1 PSEN1 STK11 STK11 MED1 MED1 EPHA2 EPHA2 IFT57 IFT57 LOXL2 LOXL2 H3AVL9_LATCH H3AVL9_LATCH LGR4 LGR4 KDF1 KDF1 FST FST CAV2 CAV2 SAV1 SAV1 IFT74 IFT74 PIK3CB PIK3CB ZEB1 ZEB1 FGF1 FGF1 LOC102365494 LOC102365494 NOX5 NOX5 HGF HGF SCARB1 SCARB1 LOC102356737 LOC102356737 TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3B2C8_LATCHUncharacterized protein. (389 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
NKX2-5NK2 homeobox 5. (296 aa)
ARAndrogen receptor. (412 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
COL8A1Collagen type VIII alpha 1 chain. (719 aa)
PPARDPeroxisome proliferator activated receptor delta. (396 aa)
BAK1BCL2 antagonist/killer 1. (239 aa)
NKX2-8NK2 homeobox 8. (225 aa)
H3BA30_LATCHFHA domain-containing protein. (939 aa)
PDX1Pancreatic and duodenal homeobox 1. (257 aa)
NF1Neurofibromin 1. (2814 aa)
ESRP2Epithelial splicing regulatory protein 2. (721 aa)
HNF1AHNF1 homeobox A. (624 aa)
TGFATransforming growth factor alpha. (140 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
DRD2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
WDR77WD repeat domain 77. (322 aa)
IFT52Intraflagellar transport 52. (440 aa)
PROK2Prokineticin 2. (159 aa)
BMPERBMP binding endothelial regulator. (682 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (625 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
LOC102355548Gb3_synth domain-containing protein. (332 aa)
CEBPBCCAAT/enhancer-binding protein. (291 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (420 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
MTSS1MTSS I-BAR domain containing 1. (636 aa)
PTCH1Patched 1. (1287 aa)
NRARPNOTCH regulated ankyrin repeat protein. (112 aa)
LOC102355995Gb3_synth domain-containing protein. (222 aa)
RB1Uncharacterized protein. (411 aa)
PHOX2BPaired like homeobox 2B. (287 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (480 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (188 aa)
H3A8H2_LATCHUncharacterized protein. (541 aa)
BCL2L2BCL2 like 2. (189 aa)
BAXUncharacterized protein. (223 aa)
FGL1Fibrinogen like 1. (315 aa)
LTALymphotoxin alpha. (166 aa)
CCN3Cellular communication network factor 3. (345 aa)
IGFBP5Insulin like growth factor binding protein 5. (279 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
AREGAmphiregulin. (235 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (285 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
IL6Uncharacterized protein. (149 aa)
EAF2ELL associated factor 2. (257 aa)
HLXH2.0 like homeobox. (384 aa)
VSTM4V-set and transmembrane domain containing 4. (328 aa)
EHFETS homologous factor. (302 aa)
H3AM65_LATCHMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
FLCNFolliculin. (576 aa)
NCSTNNicastrin. (680 aa)
TEKTEK receptor tyrosine kinase. (914 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
LOXL4Lysyl oxidase like 4. (765 aa)
BADUncharacterized protein. (175 aa)
IFT80Intraflagellar transport 80. (780 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (338 aa)
LOC102359041Zgc:153993. (208 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
EPHA2Uncharacterized protein. (979 aa)
IFT57Intraflagellar transport 57. (428 aa)
LOXL2Lysyl oxidase like 2. (773 aa)
H3AVL9_LATCHLysyl oxidase-like 3b. (475 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
KDF1Keratinocyte differentiation factor 1. (380 aa)
FSTFollistatin. (319 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
SAV1Salvador family WW domain containing protein 1. (393 aa)
IFT74Intraflagellar transport 74. (234 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1076 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC102365494Gb3_synth domain-containing protein. (331 aa)
NOX5NADPH oxidase 5. (939 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)
LOC102356737Gb3_synth domain-containing protein. (346 aa)
TP63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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