(58 nodes) Positive regulation of inflammatory response network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102367457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	LOC102346338	ZP domain-containing protein. (328 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	H3B2E5_LATCH	C2 domain-containing protein. (466 aa)
	STAP1	Signal transducing adaptor family member 1. (239 aa)
	H3B4J4_LATCH	Uncharacterized protein. (982 aa)
	H3B5T3_LATCH	C2 calcium dependent domain containing 4A. (397 aa)
	TRADD	Death domain-containing protein. (313 aa)
	H3B9K7_LATCH	SEFIR domain-containing protein. (774 aa)
	LOC102356272	Lysine--tRNA ligase. (511 aa)
	TNIP1	TNFAIP3 interacting protein 1. (532 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	LOC102365646	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	NMI	N-myc and STAT interactor. (372 aa)
	VAMP8	Vesicle associated membrane protein 8. (104 aa)
	NAPEPLD	N-acyl phosphatidylethanolamine phospholipase D. (263 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	SETD4	SET domain containing 4. (416 aa)
	LGALS2	Galectin. (137 aa)
	H3ABK5_LATCH	Protein kinase domain-containing protein. (360 aa)
	PDE2A	Phosphodiesterase. (705 aa)
	KARS1	Lysine--tRNA ligase. (618 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	SNX4	Sorting nexin 4. (405 aa)
	IFI35	NID domain-containing protein. (215 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	IL6	Uncharacterized protein. (149 aa)
	PARK7	Parkinsonism associated deglycase. (217 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	H3AKB9_LATCH	Uncharacterized protein. (498 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	LOC102356355	TNFR-Cys domain-containing protein. (163 aa)
	C2CD4C	C2 calcium dependent domain containing 4C. (444 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	GPR4	G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	TNIP3	TNFAIP3 interacting protein 3. (269 aa)
	PDCD4	Programmed cell death 4. (466 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	H3B0U5_LATCH	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (436 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1208 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	LOC102362374	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (316 aa)
	LOC102351646	Si:dkey-165a24.9; Belongs to the G-protein coupled receptor 1 family. (317 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	LOC102346194	C2 domain-containing protein. (436 aa)
	LOC102358678	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	MDK	Midkine. (141 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	AIM2	HIN-200 domain-containing protein. (205 aa)
	IL18	Uncharacterized protein. (200 aa)
	LOC102358920	Programmed cell death 4a. (244 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	CTSC	Cathepsin C; Belongs to the peptidase C1 family. (461 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	IL18	ENSLACP00000021844	ENSLACP00000021930	HIN-200 domain-containing protein.	Uncharacterized protein.	0.717
AIM2	LOC102349920	ENSLACP00000021844	ENSLACP00000010067	HIN-200 domain-containing protein.	Uncharacterized protein.	0.948
AIM2	TLR9	ENSLACP00000021844	ENSLACP00000020965	HIN-200 domain-containing protein.	Toll-like receptor 9.	0.531
APP	CTSC	ENSLACP00000001643	ENSLACP00000001648	Amyloid beta precursor protein.	Cathepsin C; Belongs to the peptidase C1 family.	0.420
APP	IL6	ENSLACP00000001643	ENSLACP00000009318	Amyloid beta precursor protein.	Uncharacterized protein.	0.443
CCR7	IL6	ENSLACP00000015163	ENSLACP00000009318	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.572
CEBPB	IL6	ENSLACP00000002325	ENSLACP00000009318	CCAAT/enhancer-binding protein.	Uncharacterized protein.	0.543
CEBPB	NFKBIA	ENSLACP00000002325	ENSLACP00000020134	CCAAT/enhancer-binding protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.553
CTSC	APP	ENSLACP00000001648	ENSLACP00000001643	Cathepsin C; Belongs to the peptidase C1 family.	Amyloid beta precursor protein.	0.420
H2ZS97_LATCH	IL6	ENSLACP00000000268	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H2ZS97_LATCH	LOC102356355	ENSLACP00000000268	ENSLACP00000010674	TNF_2 domain-containing protein.	TNFR-Cys domain-containing protein.	0.639
H3ABK5_LATCH	H3AKB9_LATCH	ENSLACP00000007026	ENSLACP00000010090	Protein kinase domain-containing protein.	Uncharacterized protein.	0.900
H3AEV1_LATCH	IL6	ENSLACP00000008172	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H3AEV1_LATCH	LOC102356355	ENSLACP00000008172	ENSLACP00000010674	TNF_2 domain-containing protein.	TNFR-Cys domain-containing protein.	0.639
H3AEV1_LATCH	TNFSF11	ENSLACP00000008172	ENSLACP00000009224	TNF_2 domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.448
H3AKB9_LATCH	H3ABK5_LATCH	ENSLACP00000010090	ENSLACP00000007026	Uncharacterized protein.	Protein kinase domain-containing protein.	0.900
IFI35	NMI	ENSLACP00000009062	ENSLACP00000003152	NID domain-containing protein.	N-myc and STAT interactor.	0.899
IL16	IL18	ENSLACP00000015832	ENSLACP00000021930	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.	Uncharacterized protein.	0.412
IL16	IL6ST	ENSLACP00000015832	ENSLACP00000010218	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.	Interleukin 6 signal transducer.	0.502
IL18	AIM2	ENSLACP00000021930	ENSLACP00000021844	Uncharacterized protein.	HIN-200 domain-containing protein.	0.717