(43 nodes) Regulation of phagocytosis network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	PLD2-2	Uncharacterized protein. (392 aa)
	COLEC11	Collectin subfamily member 11. (274 aa)
	LOC102367350	Fibronectin type-III domain-containing protein. (406 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (897 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	LETMD1	LETM1 domain containing 1. (316 aa)
	MASP1	Mannan binding lectin serine peptidase 1. (745 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	GAS6	Uncharacterized protein. (681 aa)
	LOC102365063	Apolipoprotein A-IV b, tandem duplicate 2. (252 aa)
	STAP1	Signal transducing adaptor family member 1. (239 aa)
	CNN2	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (302 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	FCN3	Fibrinogen C-terminal domain-containing protein. (331 aa)
	H3B766_LATCH	Fibrinogen C-terminal domain-containing protein. (257 aa)
	ATG3	Autophagy-related protein 3. (314 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	MASP2	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (557 aa)
	AHSG	Alpha 2-HS glycoprotein. (252 aa)
	LYAR	Ly1 antibody reactive. (403 aa)
	APOA1	Uncharacterized protein. (237 aa)
	COLEC10	Collectin subfamily member 10. (271 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	LOC102349509	Ig-like domain-containing protein. (269 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	H2ZVF8_LATCH	Uncharacterized protein. (313 aa)
	PTX3	Uncharacterized protein. (423 aa)
	H2ZX51_LATCH	Uncharacterized protein. (327 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	SYT11	Synaptotagmin 11. (429 aa)
	TMEM147	Transmembrane protein 147. (225 aa)
	ANO6	Anoctamin. (766 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	CYBA	Cytochrome b-245 alpha chain. (187 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL1	ENSLACP00000000452	ENSLACP00000012610	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.555
ADIPOQ	APPL2	ENSLACP00000000452	ENSLACP00000000307	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
AHSG	LOC102365063	ENSLACP00000020153	ENSLACP00000016264	Alpha 2-HS glycoprotein.	Apolipoprotein A-IV b, tandem duplicate 2.	0.758
APPL1	ADIPOQ	ENSLACP00000012610	ENSLACP00000000452	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adiponectin, C1Q and collagen domain containing.	0.555
APPL1	APPL2	ENSLACP00000012610	ENSLACP00000000307	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.997
APPL1	C1QTNF9	ENSLACP00000012610	ENSLACP00000014983	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	C1q domain-containing protein.	0.554
APPL1	LOC102346019	ENSLACP00000012610	ENSLACP00000019134	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	C1q domain-containing protein.	0.554
APPL1	RAB31	ENSLACP00000012610	ENSLACP00000008305	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	RAB31, member RAS oncogene family.	0.872
APPL2	ADIPOQ	ENSLACP00000000307	ENSLACP00000000452	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.554
APPL2	APPL1	ENSLACP00000000307	ENSLACP00000012610	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.997
APPL2	C1QTNF9	ENSLACP00000000307	ENSLACP00000014983	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.554
APPL2	LOC102346019	ENSLACP00000000307	ENSLACP00000019134	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.554
APPL2	RAB31	ENSLACP00000000307	ENSLACP00000008305	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	RAB31, member RAS oncogene family.	0.872
ATG3	ATG5	ENSLACP00000018815	ENSLACP00000015035	Autophagy-related protein 3.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG5	ATG3	ENSLACP00000015035	ENSLACP00000018815	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 3.	0.999
C1QTNF9	APPL1	ENSLACP00000014983	ENSLACP00000012610	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.554
C1QTNF9	APPL2	ENSLACP00000014983	ENSLACP00000000307	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
COLEC10	COLEC11	ENSLACP00000022752	ENSLACP00000009364	Collectin subfamily member 10.	Collectin subfamily member 11.	0.975
COLEC10	FCN3	ENSLACP00000022752	ENSLACP00000017658	Collectin subfamily member 10.	Fibrinogen C-terminal domain-containing protein.	0.663