STRINGSTRING
FGF1 FGF1 PODNL1 PODNL1 LOC102364376 LOC102364376 H6PD H6PD WNT4 WNT4 SNAI1 SNAI1 H3BE69_LATCH H3BE69_LATCH ABCG4 ABCG4 DDX20 DDX20 SF1 SF1 FGFR4 FGFR4 APOB APOB H3B0K2_LATCH H3B0K2_LATCH H2ZS97_LATCH H2ZS97_LATCH LOC102355368 LOC102355368 STARD4 STARD4 LPCAT3 LPCAT3 H2ZYB6_LATCH H2ZYB6_LATCH H2ZYH3_LATCH H2ZYH3_LATCH SCAP SCAP ARMC5 ARMC5 ABCG1 ABCG1 DGKQ DGKQ IGF2 IGF2 SREBF2 SREBF2 CGA CGA PODN PODN SNAI2 SNAI2 LOC102350759 LOC102350759 LOC102354799 LOC102354799 LTA LTA NR0B1 NR0B1 H3AEV1_LATCH H3AEV1_LATCH CYP7A1 CYP7A1 SIRT1 SIRT1 ERLIN1 ERLIN1 STAR STAR ASAH1 ASAH1 NR1D1 NR1D1 LEP LEP H3AP48_LATCH H3AP48_LATCH ERLIN2 ERLIN2 BMP6 BMP6 DKK3 DKK3 FGF19 FGF19 DAB2 DAB2 SREBF1 SREBF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PODNL1Podocan like 1. (599 aa)
LOC102364376Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (793 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SNAI1Snail family transcriptional repressor 1. (257 aa)
H3BE69_LATCHPID domain-containing protein. (136 aa)
ABCG4ATP binding cassette subfamily G member 4. (653 aa)
DDX20DEAD-box helicase 20. (805 aa)
SF1Splicing factor 1. (547 aa)
FGFR4Fibroblast growth factor receptor. (810 aa)
APOBApolipoprotein B. (4644 aa)
H3B0K2_LATCHSTART domain-containing protein. (279 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
LOC102355368NR LBD domain-containing protein. (170 aa)
STARD4StAR related lipid transfer domain containing 4. (216 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (430 aa)
H2ZYB6_LATCHUncharacterized protein. (324 aa)
H2ZYH3_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SCAPSREBF chaperone. (1283 aa)
ARMC5Armadillo repeat containing 5. (811 aa)
ABCG1ATP binding cassette subfamily G member 1. (649 aa)
DGKQDiacylglycerol kinase. (940 aa)
IGF2Insulin like growth factor 2. (207 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1083 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
PODNPodocan. (621 aa)
SNAI2Snail family zinc finger 2. (268 aa)
LOC102350759SEC14-like lipid binding 8. (356 aa)
LOC102354799Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
LTALymphotoxin alpha. (166 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (261 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1. (514 aa)
SIRT1Sirtuin 1. (729 aa)
ERLIN1ER lipid raft associated 1. (328 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (332 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
H3AP48_LATCHDickkopf_N domain-containing protein. (253 aa)
ERLIN2ER lipid raft associated 2. (338 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
DAB2DAB adaptor protein 2. (745 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1100 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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