(74 nodes) Antigen receptor-mediated signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EIF2B2	Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (400 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
	BMX	Tyrosine-protein kinase. (677 aa)
	MORN5	MORN repeat containing 5. (172 aa)
	M3XIM8_LATCH	Ig-like domain-containing protein. (241 aa)
	M3XIR6_LATCH	Uncharacterized protein. (269 aa)
	HHLA2	Ig-like domain-containing protein. (145 aa)
	NFATC2	Nuclear factor of activated T cells 2. (912 aa)
	TEC	Tyrosine-protein kinase. (662 aa)
	H2ZRT0_LATCH	Ig-like domain-containing protein. (125 aa)
	SPG21	SPG21 abhydrolase domain containing, maspardin. (310 aa)
	RC3H2	RING-type domain-containing protein. (352 aa)
	H2ZSV7_LATCH	Uncharacterized protein. (242 aa)
	EIF2B4	Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (533 aa)
	H2ZTT6_LATCH	Phosphoinositide phospholipase C. (404 aa)
	H2ZU89_LATCH	Uncharacterized protein. (241 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (279 aa)
	LOC102364341	Uncharacterized protein. (271 aa)
	RNF31	Uncharacterized protein. (1087 aa)
	PTPN6	Protein tyrosine phosphatase non-receptor type 6. (338 aa)
	TXK	Tyrosine-protein kinase. (426 aa)
	BLK	Tyrosine-protein kinase. (447 aa)
	GATA3	GATA binding protein 3. (447 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	LCP2	Lymphocyte cytosolic protein 2. (518 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (914 aa)
	LOC102352804	Phosphoinositide phospholipase C. (1172 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	H3A3I6_LATCH	Ig-like domain-containing protein. (119 aa)
	THEMIS2	Thymocyte selection associated family member 2. (572 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	RBCK1	IBR domain-containing protein. (175 aa)
	CD247	CD247 molecule. (166 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	BAX	Uncharacterized protein. (223 aa)
	H3ABW1_LATCH	ANK_REP_REGION domain-containing protein. (323 aa)
	CD79A	CD79a molecule, immunoglobulin-associated alpha. (227 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	THY1	Thy-1 cell surface antigen. (165 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	CTLA4	IG domain-containing protein. (186 aa)
	H3AKJ7_LATCH	DENN/MADD domain containing 1B. (493 aa)
	TMEM269	Transmembrane protein 269; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (242 aa)
	THEMIS	Thymocyte selection associated. (564 aa)
	STOML2	Stomatin like 2. (294 aa)
	FYB1	FYN binding protein 1. (843 aa)
	DENND1B	UDENN domain-containing protein. (268 aa)
	KHDRBS1	KH RNA binding domain containing, signal transduction associated 1. (318 aa)
	SHARPIN	Uncharacterized protein. (681 aa)
	H3ASJ2_LATCH	ANK_REP_REGION domain-containing protein. (303 aa)
	LOC102353314	Uncharacterized protein. (616 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (718 aa)
	CACNB4	Calcium channel, voltage-dependent, beta 4a subunit. (477 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	ITK	Tyrosine-protein kinase. (624 aa)
	VTCN1-2	Uncharacterized protein. (232 aa)
	CD276	CD276 molecule. (324 aa)
	TNFRSF21	TNF receptor superfamily member 21. (651 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	KLHL6	Kelch like family member 6. (613 aa)
	EIF2B1	Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (312 aa)
	BTK	Tyrosine-protein kinase. (646 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	H3BDY7_LATCH	Uncharacterized protein. (220 aa)
	SPPL3	Signal peptide peptidase like 3. (385 aa)
	H3BI75_LATCH	Uncharacterized protein. (110 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	BLK	ENSLACP00000003747	ENSLACP00000003363	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.444
BCAR1	CRKL	ENSLACP00000003747	ENSLACP00000014901	BCAR1 scaffold protein, Cas family member.	CRK like proto-oncogene, adaptor protein.	0.815
BCAR1	LOC102364341	ENSLACP00000003747	ENSLACP00000001390	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein.	0.815
BCAR1	LYN	ENSLACP00000003747	ENSLACP00000006462	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.715
BLK	BCAR1	ENSLACP00000003363	ENSLACP00000003747	Tyrosine-protein kinase.	BCAR1 scaffold protein, Cas family member.	0.444
BLK	BRAF	ENSLACP00000003363	ENSLACP00000012774	Tyrosine-protein kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.507
BLK	CD247	ENSLACP00000003363	ENSLACP00000005871	Tyrosine-protein kinase.	CD247 molecule.	0.479
BLK	CD79A	ENSLACP00000003363	ENSLACP00000007655	Tyrosine-protein kinase.	CD79a molecule, immunoglobulin-associated alpha.	0.712
BLK	CRKL	ENSLACP00000003363	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.408
BLK	KHDRBS1	ENSLACP00000003363	ENSLACP00000011752	Tyrosine-protein kinase.	KH RNA binding domain containing, signal transduction associated 1.	0.411
BLK	LCP2	ENSLACP00000003363	ENSLACP00000003707	Tyrosine-protein kinase.	Lymphocyte cytosolic protein 2.	0.473
BLK	LOC102364341	ENSLACP00000003363	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.408
BLK	PTPN6	ENSLACP00000003363	ENSLACP00000002763	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 6.	0.411
BLK	PTPRC	ENSLACP00000003363	ENSLACP00000003518	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.469
BLK	SYK	ENSLACP00000003363	ENSLACP00000012982	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.510
BLK	ZAP70	ENSLACP00000003363	ENSLACP00000008633	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.536
BMX	CD247	ENSLACP00000021868	ENSLACP00000005871	Tyrosine-protein kinase.	CD247 molecule.	0.518
BMX	CD79A	ENSLACP00000021868	ENSLACP00000007655	Tyrosine-protein kinase.	CD79a molecule, immunoglobulin-associated alpha.	0.474
BMX	H2ZTT6_LATCH	ENSLACP00000021868	ENSLACP00000000807	Tyrosine-protein kinase.	Phosphoinositide phospholipase C.	0.575
BMX	LCP2	ENSLACP00000021868	ENSLACP00000003707	Tyrosine-protein kinase.	Lymphocyte cytosolic protein 2.	0.789