(31 nodes) Regulation of antigen receptor-mediated signaling pathway network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102353021	Uncharacterized protein. (644 aa)
	LOC102362769	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	SLA2	Src like adaptor 2. (259 aa)
	LOC102353843	Uncharacterized protein. (335 aa)
	SH2D1A	SH2 domain containing 1A. (124 aa)
	THY1	Thy-1 cell surface antigen. (165 aa)
	PAWR	Uncharacterized protein. (118 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	H3B0Y6_LATCH	PRKC, apoptosis, WT1, regulator. (191 aa)
	STAP1	Signal transducing adaptor family member 1. (239 aa)
	H3AUL4_LATCH	Ig-like domain-containing protein. (268 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
	H3ACR7_LATCH	Uncharacterized protein. (460 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	EZR	Ezrin. (591 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	H3A807_LATCH	Uncharacterized protein. (507 aa)
	PHPT1	Phosphohistidine phosphatase 1. (120 aa)
	CMTM3	CKLF like MARVEL transmembrane domain containing 3. (115 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	BLK	Tyrosine-protein kinase. (447 aa)
	RAB29	RAB29, member RAS oncogene family. (206 aa)
	PTPN6	Protein tyrosine phosphatase non-receptor type 6. (338 aa)
	UBASH3A	Ubiquitin associated and SH3 domain containing A. (590 aa)
	LOC102349364	Si:dkey-51e6.1. (145 aa)
	TESPA1	KRAP_IP3R_bind domain-containing protein. (96 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLK	H3A807_LATCH	ENSLACP00000003363	ENSLACP00000005778	Tyrosine-protein kinase.	Uncharacterized protein.	0.456
BLK	H3ACR7_LATCH	ENSLACP00000003363	ENSLACP00000007438	Tyrosine-protein kinase.	Uncharacterized protein.	0.456
BLK	PTPN2	ENSLACP00000003363	ENSLACP00000005814	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.458
BLK	PTPN6	ENSLACP00000003363	ENSLACP00000002763	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 6.	0.411
BLK	PTPRC	ENSLACP00000003363	ENSLACP00000003518	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.469
BLK	SH2D1A	ENSLACP00000003363	ENSLACP00000022553	Tyrosine-protein kinase.	SH2 domain containing 1A.	0.447
CARD11	H3B0U4_LATCH	ENSLACP00000004229	ENSLACP00000015515	Caspase recruitment domain family member 11.	MALT paracaspase 2.	0.899
CARD11	LOC102353021	ENSLACP00000004229	ENSLACP00000018014	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.853
CARD11	MALT1	ENSLACP00000004229	ENSLACP00000004155	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.899
CCR7	PTPRC	ENSLACP00000015163	ENSLACP00000003518	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Protein tyrosine phosphatase receptor type C.	0.635
H3A807_LATCH	BLK	ENSLACP00000005778	ENSLACP00000003363	Uncharacterized protein.	Tyrosine-protein kinase.	0.456
H3A807_LATCH	LYN	ENSLACP00000005778	ENSLACP00000006462	Uncharacterized protein.	Tyrosine-protein kinase.	0.679
H3A807_LATCH	PTPN6	ENSLACP00000005778	ENSLACP00000002763	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.818
H3A807_LATCH	PTPRC	ENSLACP00000005778	ENSLACP00000003518	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.637
H3ACR7_LATCH	BLK	ENSLACP00000007438	ENSLACP00000003363	Uncharacterized protein.	Tyrosine-protein kinase.	0.456
H3ACR7_LATCH	LYN	ENSLACP00000007438	ENSLACP00000006462	Uncharacterized protein.	Tyrosine-protein kinase.	0.679
H3ACR7_LATCH	PTPN6	ENSLACP00000007438	ENSLACP00000002763	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.818
H3ACR7_LATCH	PTPRC	ENSLACP00000007438	ENSLACP00000003518	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.637
H3AUL4_LATCH	TESPA1	ENSLACP00000013335	ENSLACP00000016465	Ig-like domain-containing protein.	KRAP_IP3R_bind domain-containing protein.	0.428
H3B0U4_LATCH	CARD11	ENSLACP00000015515	ENSLACP00000004229	MALT paracaspase 2.	Caspase recruitment domain family member 11.	0.899