(18 nodes) Brown fat cell differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	ZNF516	Zinc finger protein 516. (1157 aa)
	LRG1	LRRCT domain-containing protein. (337 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	ADRB3	Adrenoceptor beta 3a. (407 aa)
	ADRB2	Adrenoceptor beta 2. (432 aa)
	METRNL	Meteorin like, glial cell differentiation regulator. (288 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	ADRB1	Adrenoceptor beta 1. (394 aa)
	LAMA4	Laminin subunit alpha 4. (1721 aa)
	H3BB14_LATCH	Uncharacterized protein. (123 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	DIO2	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (130 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (475 aa)
	LAMB3	Laminin subunit beta 3. (1160 aa)
	PRDM16-2	Si:ch211-263k4.2. (114 aa)
	PRDM16	PR/SET domain 16. (1135 aa)
	DHRS7B	Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	ADRB3	ENSLACP00000000452	ENSLACP00000002909	Adiponectin, C1Q and collagen domain containing.	Adrenoceptor beta 3a.	0.445
ADIPOQ	CEBPB	ENSLACP00000000452	ENSLACP00000002325	Adiponectin, C1Q and collagen domain containing.	CCAAT/enhancer-binding protein.	0.632
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADRB1	ADRB3	ENSLACP00000011780	ENSLACP00000002909	Adrenoceptor beta 1.	Adrenoceptor beta 3a.	0.668
ADRB2	ADRB3	ENSLACP00000003966	ENSLACP00000002909	Adrenoceptor beta 2.	Adrenoceptor beta 3a.	0.680
ADRB3	ADIPOQ	ENSLACP00000002909	ENSLACP00000000452	Adrenoceptor beta 3a.	Adiponectin, C1Q and collagen domain containing.	0.445
ADRB3	ADRB1	ENSLACP00000002909	ENSLACP00000011780	Adrenoceptor beta 3a.	Adrenoceptor beta 1.	0.668
ADRB3	ADRB2	ENSLACP00000002909	ENSLACP00000003966	Adrenoceptor beta 3a.	Adrenoceptor beta 2.	0.680
CEBPB	ADIPOQ	ENSLACP00000002325	ENSLACP00000000452	CCAAT/enhancer-binding protein.	Adiponectin, C1Q and collagen domain containing.	0.632
CEBPB	H3BB14_LATCH	ENSLACP00000002325	ENSLACP00000019085	CCAAT/enhancer-binding protein.	Uncharacterized protein.	0.508
CEBPB	LOC102346019	ENSLACP00000002325	ENSLACP00000019134	CCAAT/enhancer-binding protein.	C1q domain-containing protein.	0.515
CEBPB	PRDM16	ENSLACP00000002325	ENSLACP00000021648	CCAAT/enhancer-binding protein.	PR/SET domain 16.	0.508
CEBPB	PRDM16-2	ENSLACP00000002325	ENSLACP00000021617	CCAAT/enhancer-binding protein.	Si:ch211-263k4.2.	0.508
DIO2	PRDM16-2	ENSLACP00000019285	ENSLACP00000021617	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Si:ch211-263k4.2.	0.490
H3BB14_LATCH	CEBPB	ENSLACP00000019085	ENSLACP00000002325	Uncharacterized protein.	CCAAT/enhancer-binding protein.	0.508
H3BB14_LATCH	PRDM16	ENSLACP00000019085	ENSLACP00000021648	Uncharacterized protein.	PR/SET domain 16.	0.443
H3BB14_LATCH	ZNF516	ENSLACP00000019085	ENSLACP00000000812	Uncharacterized protein.	Zinc finger protein 516.	0.521
LAMA4	LAMB3	ENSLACP00000017089	ENSLACP00000021201	Laminin subunit alpha 4.	Laminin subunit beta 3.	0.703
LAMB3	LAMA4	ENSLACP00000021201	ENSLACP00000017089	Laminin subunit beta 3.	Laminin subunit alpha 4.	0.703
LOC102346019	ADIPOQ	ENSLACP00000019134	ENSLACP00000000452	C1q domain-containing protein.	Adiponectin, C1Q and collagen domain containing.	0.904