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H2ZWA4_LATCH H2ZWA4_LATCH LOC102357052 LOC102357052 ELOVL1 ELOVL1 AKAP11 AKAP11 CFTR CFTR MET MET SRF SRF CYP26B1 CYP26B1 CLDN1 CLDN1 STMN1 STMN1 LOC102356063 LOC102356063 H3BIC4_LATCH H3BIC4_LATCH IL18 IL18 EXT2 EXT2 TP63 TP63 STARD7 STARD7 H3A9H6_LATCH H3A9H6_LATCH LOC102362617 LOC102362617 AQP4 AQP4 H3AEK5_LATCH H3AEK5_LATCH LOC102367411 LOC102367411 ACER1 ACER1 WFS1 WFS1 SCNN1G SCNN1G SCNN1B SCNN1B KDF1 KDF1 H2ZTZ4_LATCH H2ZTZ4_LATCH UGCG UGCG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
H2ZWA4_LATCHUncharacterized protein. (297 aa)
LOC102357052Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (302 aa)
AKAP11A-kinase anchoring protein 11. (1808 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1385 aa)
SRFSerum response factor. (520 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
CLDN1Claudin 1. (210 aa)
STMN1Stathmin; Belongs to the stathmin family. (144 aa)
LOC102356063Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (554 aa)
H3BIC4_LATCHUncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (328 aa)
IL18Uncharacterized protein. (200 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (718 aa)
TP63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
STARD7StAR related lipid transfer domain containing 7. (360 aa)
H3A9H6_LATCHFatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (264 aa)
LOC102362617Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (370 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (319 aa)
H3AEK5_LATCHAquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
LOC102367411Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (334 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (272 aa)
WFS1Wolframin ER transmembrane glycoprotein. (876 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
KDF1Keratinocyte differentiation factor 1. (380 aa)
H2ZTZ4_LATCHFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (363 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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