(94 nodes) Leukocyte migration network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIMP1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (311 aa)
	CRK	CRK proto-oncogene, adaptor protein. (310 aa)
	LOC102346566	Annexin. (343 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	JAM3	Junctional adhesion molecule 3. (208 aa)
	LOC102355766	Uncharacterized protein. (524 aa)
	LOC102359313	Uncharacterized protein. (334 aa)
	LOC102347764	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (231 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	H3AYQ4_LATCH	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	NKX2-3	NK2 homeobox 3. (334 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1473 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2113 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1208 aa)
	ITGA9	Integrin subunit alpha 9. (480 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	GAS6	Uncharacterized protein. (681 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
	CD99L2	CD99 molecule like 2. (246 aa)
	LOC102366874	Chemokine (C-X-C motif) receptor 3, tandem duplicate 2; Belongs to the G-protein coupled receptor 1 family. (395 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (224 aa)
	JAGN1	Jagunal homolog 1. (183 aa)
	TAFA4	TAFA chemokine like family member 4. (95 aa)
	MSN	Moesin. (583 aa)
	H3B5Z8_LATCH	Uncharacterized protein. (606 aa)
	PTN	Pleiotrophin. (167 aa)
	LOC102354417	Uncharacterized protein. (723 aa)
	GBF1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1912 aa)
	MCOLN2	Mucolipin 2. (538 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (454 aa)
	H3B9K7_LATCH	SEFIR domain-containing protein. (774 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1029 aa)
	TNFSF14	TNF_2 domain-containing protein. (238 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	NF1	Neurofibromin 1. (2814 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	ADD2	Adducin 2. (742 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
	LOC102354752	VPS9 domain-containing protein. (197 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	CSF3R	Colony stimulating factor 3 receptor. (826 aa)
	SPNS2	Sphingolipid transporter 2. (362 aa)
	MDK	Midkine. (141 aa)
	CD34	Uncharacterized protein. (378 aa)
	RABGEF1	RAB guanine nucleotide exchange factor (GEF) 1. (532 aa)
	LOC102351798	Galectin. (167 aa)
	LGALS3	Galectin. (274 aa)
	LOC102352351	C-C motif chemokine. (88 aa)
	LOC102365550	Uncharacterized protein. (218 aa)
	LOC102349637	Uncharacterized protein. (767 aa)
	CD99	CD99 molecule (Xg blood group). (201 aa)
	SLC37A4	Solute carrier family 37 member 4. (441 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (397 aa)
	PODXL2	Podocalyxin like 2. (548 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	H3AGL7_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (305 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	DBH	Dopamine beta-hydroxylase. (617 aa)
	JAM2	Junctional adhesion molecule 2. (292 aa)
	ANO6	Anoctamin. (766 aa)
	LOC102348541	Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	BSG	Basigin (Ok blood group). (368 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1077 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (480 aa)
	LOC102348280	Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (297 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2039 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	LOC102358678	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	H2ZU28_LATCH	SEFIR domain-containing protein. (634 aa)
	LOC102347948	Uncharacterized protein. (290 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1222 aa)
	LOC102364341	Uncharacterized protein. (271 aa)
	SCG2	Secretogranin II. (621 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	H2ZX10_LATCH	Uncharacterized protein. (436 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	LOC102367457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1185 aa)
	H2ZXZ3_LATCH	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (901 aa)
	GOLPH3	Golgi phosphoprotein 3. (294 aa)
	H2ZZB2_LATCH	ZP domain-containing protein. (438 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	H2ZZU4_LATCH	Selectin E. (554 aa)
	GATA3	GATA binding protein 3. (447 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (658 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIMP1	SRP54	ENSLACP00000012229	ENSLACP00000020361	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1.	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.	0.521
CCR6	CCR7	ENSLACP00000023429	ENSLACP00000015163	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.425
CCR6	GATA3	ENSLACP00000023429	ENSLACP00000003446	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	GATA binding protein 3.	0.454
CCR7	CCR6	ENSLACP00000015163	ENSLACP00000023429	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.425
CCR7	CD34	ENSLACP00000015163	ENSLACP00000021425	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.542
CCR7	CXCR5	ENSLACP00000015163	ENSLACP00000019594	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.872
CCR7	H2ZXZ3_LATCH	ENSLACP00000015163	ENSLACP00000002264	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.	0.417
CCR7	H3AGL7_LATCH	ENSLACP00000015163	ENSLACP00000008788	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.500
CCR7	ITGA4	ENSLACP00000015163	ENSLACP00000016373	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.459
CCR7	LOC102348280	ENSLACP00000015163	ENSLACP00000005451	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.516
CCR7	LOC102348541	ENSLACP00000015163	ENSLACP00000006086	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.629
CCR7	LOC102352351	ENSLACP00000015163	ENSLACP00000021910	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.753
CCR7	TBX21	ENSLACP00000015163	ENSLACP00000019310	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	T-box transcription factor 21.	0.470
CD34	CCR7	ENSLACP00000021425	ENSLACP00000015163	Uncharacterized protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.542
CD34	CD99	ENSLACP00000021425	ENSLACP00000022759	Uncharacterized protein.	CD99 molecule (Xg blood group).	0.543
CD34	CD99L2	ENSLACP00000021425	ENSLACP00000016770	Uncharacterized protein.	CD99 molecule like 2.	0.511
CD34	H2ZXZ3_LATCH	ENSLACP00000021425	ENSLACP00000002264	Uncharacterized protein.	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.	0.681
CD34	H2ZZU4_LATCH	ENSLACP00000021425	ENSLACP00000002915	Uncharacterized protein.	Selectin E.	0.587
CD34	H3B5Z8_LATCH	ENSLACP00000021425	ENSLACP00000017319	Uncharacterized protein.	Uncharacterized protein.	0.533
CD34	KIT	ENSLACP00000021425	ENSLACP00000004383	Uncharacterized protein.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.687