(45 nodes) Negative regulation of chemotaxis network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RYK	Receptor like tyrosine kinase. (542 aa)
	LOC102366586	Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (825 aa)
	RIN3	Ras and Rab interactor 3. (951 aa)
	MMP28	Matrix metallopeptidase 28. (486 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	H3BF50_LATCH	Uncharacterized protein; Belongs to the semaphorin family. (733 aa)
	LOC102365809	Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1020 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (767 aa)
	LOC102361472	Si:dkey-49n23.1; Belongs to the semaphorin family. (750 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (739 aa)
	H3B6V5_LATCH	Sema domain-containing protein; Belongs to the semaphorin family. (329 aa)
	H3B672_LATCH	Uncharacterized protein; Belongs to the semaphorin family. (507 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (650 aa)
	STAP1	Signal transducing adaptor family member 1. (239 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (635 aa)
	SEMA4A	Sema domain-containing protein; Belongs to the semaphorin family. (758 aa)
	H3AY29_LATCH	Uncharacterized protein. (534 aa)
	C5	Complement C5. (1691 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	H3ANL8_LATCH	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family. (755 aa)
	LOC102366200	Uncharacterized protein; Belongs to the semaphorin family. (627 aa)
	ANGPT2	Angiopoietin 2. (493 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (550 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	CCN3	Cellular communication network factor 3. (345 aa)
	H3AC70_LATCH	LRRNT domain-containing protein. (132 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (789 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	SLIT1	Slit guidance ligand 1. (925 aa)
	SEMA3D	Semaphorin 3D; Belongs to the semaphorin family. (715 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (772 aa)
	TNFAIP6	TNF alpha induced protein 6. (279 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1076 aa)
	LOC102366847	Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (1059 aa)
	SEMA6B	Sema domain-containing protein; Belongs to the semaphorin family. (911 aa)
	GPR18	G protein-coupled receptor 18. (330 aa)
	AIF1	Allograft inflammatory factor 1. (119 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (794 aa)
	H2ZSG0_LATCH	Sema domain-containing protein. (212 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2ZSG0_LATCH	H3AY29_LATCH	ENSLACP00000000331	ENSLACP00000014550	Sema domain-containing protein.	Uncharacterized protein.	0.899
H3AC70_LATCH	SLIT1	ENSLACP00000007241	ENSLACP00000006092	LRRNT domain-containing protein.	Slit guidance ligand 1.	0.908
H3AC70_LATCH	SLIT2	ENSLACP00000007241	ENSLACP00000012299	LRRNT domain-containing protein.	Slit guidance ligand 2.	0.900
H3AY29_LATCH	H2ZSG0_LATCH	ENSLACP00000014550	ENSLACP00000000331	Uncharacterized protein.	Sema domain-containing protein.	0.899
H3AY29_LATCH	LOC102361472	ENSLACP00000014550	ENSLACP00000018280	Uncharacterized protein.	Si:dkey-49n23.1; Belongs to the semaphorin family.	0.856
H3AY29_LATCH	LOC102365809	ENSLACP00000014550	ENSLACP00000020096	Uncharacterized protein.	Si:ch211-113g11.6; Belongs to the semaphorin family.	0.544
H3AY29_LATCH	LOC102366200	ENSLACP00000014550	ENSLACP00000010997	Uncharacterized protein.	Uncharacterized protein; Belongs to the semaphorin family.	0.595
H3AY29_LATCH	SEMA3A	ENSLACP00000014550	ENSLACP00000015743	Uncharacterized protein.	Semaphorin 3A; Belongs to the semaphorin family.	0.868
H3AY29_LATCH	SEMA3C	ENSLACP00000014550	ENSLACP00000009350	Uncharacterized protein.	Semaphorin 3C; Belongs to the semaphorin family.	0.656
H3AY29_LATCH	SEMA3D	ENSLACP00000014550	ENSLACP00000005942	Uncharacterized protein.	Semaphorin 3D; Belongs to the semaphorin family.	0.826
H3AY29_LATCH	SEMA3E	ENSLACP00000014550	ENSLACP00000017973	Uncharacterized protein.	Semaphorin 3E; Belongs to the semaphorin family.	0.780
H3AY29_LATCH	SEMA3F	ENSLACP00000014550	ENSLACP00000005773	Uncharacterized protein.	Semaphorin 3F; Belongs to the semaphorin family.	0.682
H3AY29_LATCH	SEMA4A	ENSLACP00000014550	ENSLACP00000015685	Uncharacterized protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.654
H3AY29_LATCH	SEMA4B	ENSLACP00000014550	ENSLACP00000021936	Uncharacterized protein.	Semaphorin 4B; Belongs to the semaphorin family.	0.714
H3AY29_LATCH	SEMA4C	ENSLACP00000014550	ENSLACP00000002554	Uncharacterized protein.	Semaphorin 4C; Belongs to the semaphorin family.	0.784
H3AY29_LATCH	SEMA4G	ENSLACP00000014550	ENSLACP00000007229	Uncharacterized protein.	Semaphorin 4G; Belongs to the semaphorin family.	0.718
H3AY29_LATCH	SEMA6B	ENSLACP00000014550	ENSLACP00000003519	Uncharacterized protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.893
H3AY29_LATCH	SEMA6C	ENSLACP00000014550	ENSLACP00000003633	Uncharacterized protein.	Semaphorin 6C; Belongs to the semaphorin family.	0.516
H3AY29_LATCH	SEMA6D	ENSLACP00000014550	ENSLACP00000004502	Uncharacterized protein.	Semaphorin 6D; Belongs to the semaphorin family.	0.570
H3B672_LATCH	H3B6V5_LATCH	ENSLACP00000017393	ENSLACP00000017626	Uncharacterized protein; Belongs to the semaphorin family.	Sema domain-containing protein; Belongs to the semaphorin family.	0.412