(99 nodes) Cartilage development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCN2	Cellular communication network factor 2. (344 aa)
	DDRGK1	DDRGK domain containing 1. (243 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (637 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	DLX2	Distal-less homeobox 2. (278 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
	H2ZX66_LATCH	Uncharacterized protein. (641 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
	IMPAD1	Inositol monophosphatase domain containing 1. (350 aa)
	SNX19	Sorting nexin 19. (856 aa)
	LOC102350164	Uncharacterized protein. (364 aa)
	CER1	CTCK domain-containing protein. (257 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4241 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	MSX1	Msh homeobox 1. (256 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (210 aa)
	EPYC	Epiphycan. (266 aa)
	RB1	Uncharacterized protein. (411 aa)
	H3A6Z7_LATCH	Bardet-Biedl syndrome 1. (596 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	SNAI2	Snail family zinc finger 2. (268 aa)
	OSR2	Odd-skipped related transciption factor 2. (314 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	OSR1	Odd-skipped related transcription factor 1. (259 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	RARA	Retinoic acid receptor alpha. (505 aa)
	EVC	EvC ciliary complex subunit 1. (814 aa)
	RARB	NR LBD domain-containing protein. (299 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (405 aa)
	CCN3	Cellular communication network factor 3. (345 aa)
	ECM1	Uncharacterized protein. (366 aa)
	SMAD5	Mothers against decapentaplegic homolog. (467 aa)
	TAPT1	Transmembrane anterior posterior transformation 1. (597 aa)
	OTOR	Otoraplin. (128 aa)
	NOG	Noggin; Belongs to the noggin family. (223 aa)
	MEF2D	Myocyte enhancer factor 2D. (486 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	LOC106703556	Natriuretic peptide A-like. (129 aa)
	THBS3	Thrombospondin 3. (930 aa)
	LOC102364365	Natriuretic peptide A-like. (130 aa)
	SULF2	Extracellular sulfatase. (877 aa)
	LOC102366915	Uncharacterized protein. (146 aa)
	HOXD3	Homeobox D3. (419 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (408 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (220 aa)
	LOC102349503	Uncharacterized protein. (300 aa)
	PBXIP1	Uncharacterized protein. (891 aa)
	UNCX	UNC homeobox. (498 aa)
	IFT80	Intraflagellar transport 80. (780 aa)
	BMP6	Bone morphogenetic protein 6. (428 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	LOC102357384	Noggin; Belongs to the noggin family. (216 aa)
	RUNX2	Runt-related transcription factor. (452 aa)
	CHST11	Carbohydrate sulfotransferase. (298 aa)
	ADAMTS12	Peptidase M12B domain-containing protein. (1187 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	ALCAM	Activated leukocyte cell adhesion molecule. (530 aa)
	MMP13	Matrix metallopeptidase 13. (467 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1076 aa)
	MATN3	Matrilin 3. (267 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	RUNX3	RUNX family transcription factor 3. (179 aa)
	ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif 7. (1594 aa)
	H3B277_LATCH	Uncharacterized protein. (4290 aa)
	ARID5A	AT-rich interaction domain 5A. (583 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	SRF	Serum response factor. (520 aa)
	HOXB3	Homeobox B3. (404 aa)
	H3B4Z2_LATCH	Pep_M12B_propep domain-containing protein. (169 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (724 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
	RUNX1-2	RUNX family transcription factor 1. (242 aa)
	RUNX1	Runt domain-containing protein. (191 aa)
	SULF1	Sulfatase 1. (1129 aa)
	RARG	Retinoic acid receptor gamma. (389 aa)
	HOXC4	Homeobox C4. (439 aa)
	EDN1	Endothelin 1. (216 aa)
	ANXA6	Annexin. (662 aa)
	HOXA3	Homeobox A3. (411 aa)
	CCN1	Cellular communication network factor 1. (368 aa)
	HOXA5	Homeobox A5. (269 aa)
	SOX6	SRY-box transcription factor 6. (814 aa)
	SNAI1	Snail family transcriptional repressor 1. (257 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	BARX2	BARX homeobox 2. (277 aa)
	H3BEX6_LATCH	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (420 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (196 aa)
	TRIP11	Thyroid hormone receptor interactor 11. (1997 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (958 aa)
	SOX5	SRY-box transcription factor 5. (757 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (718 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS12	H3B4Z2_LATCH	ENSLACP00000013711	ENSLACP00000016963	Peptidase M12B domain-containing protein.	Pep_M12B_propep domain-containing protein.	0.899
ANXA6	THBS3	ENSLACP00000019578	ENSLACP00000009179	Annexin.	Thrombospondin 3.	0.408
ARID5A	RB1	ENSLACP00000016039	ENSLACP00000005360	AT-rich interaction domain 5A.	Uncharacterized protein.	0.446
BBS2	H3A6Z7_LATCH	ENSLACP00000017026	ENSLACP00000005418	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 1.	0.998
BBS2	IFT80	ENSLACP00000017026	ENSLACP00000012116	Bardet-Biedl syndrome 2 protein homolog.	Intraflagellar transport 80.	0.479
BBS2	MKKS	ENSLACP00000017026	ENSLACP00000006659	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.427
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	BMP6	ENSLACP00000016168	ENSLACP00000012388	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.666
BMP2	BMPR1A	ENSLACP00000016168	ENSLACP00000002058	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.869
BMP2	BMPR1B	ENSLACP00000016168	ENSLACP00000001526	Bone morphogenetic protein 2.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.986
BMP2	BMPR2	ENSLACP00000016168	ENSLACP00000017144	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.973
BMP2	CER1	ENSLACP00000016168	ENSLACP00000003380	Bone morphogenetic protein 2.	CTCK domain-containing protein.	0.528
BMP2	FGF18	ENSLACP00000016168	ENSLACP00000015472	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
BMP2	FGF4	ENSLACP00000016168	ENSLACP00000014225	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP2	FGF6	ENSLACP00000016168	ENSLACP00000020525	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.409
BMP2	H3BEX6_LATCH	ENSLACP00000016168	ENSLACP00000020447	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.749
BMP2	LOC102356182	ENSLACP00000016168	ENSLACP00000006376	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508
BMP2	LOC102357384	ENSLACP00000016168	ENSLACP00000012793	Bone morphogenetic protein 2.	Noggin; Belongs to the noggin family.	0.945
BMP2	NOG	ENSLACP00000016168	ENSLACP00000008674	Bone morphogenetic protein 2.	Noggin; Belongs to the noggin family.	0.951
BMP2	RUNX2	ENSLACP00000016168	ENSLACP00000013109	Bone morphogenetic protein 2.	Runt-related transcription factor.	0.473