(70 nodes) Negative regulation of protein transport network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADTRP	Uncharacterized protein. (229 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	PIM3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (324 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	RAB11FIP5	RAB11 family interacting protein 5. (389 aa)
	CD200	Uncharacterized protein. (224 aa)
	OPRD1	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	LOC102352528	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	PIM2	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (324 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)
	FRMD4A	FERM domain containing 4A. (993 aa)
	SVIP	Si:ch73-147o17.1. (80 aa)
	CCN3	Cellular communication network factor 3. (345 aa)
	GOPC	Golgi-associated PDZ and coiled-coil motif containing. (456 aa)
	ERLEC1	Endoplasmic reticulum lectin 1. (486 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	LOC102361922	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	WWP2	E3 ubiquitin-protein ligase. (883 aa)
	SIRT6	Sirtuin 6. (375 aa)
	LOC102347917	Uncharacterized protein. (301 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	MIDN	Midnolin. (524 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
	UBE2J1	Ubiquitin conjugating enzyme E2 J1. (321 aa)
	DERL3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (203 aa)
	SNX12	Sorting nexin 12. (174 aa)
	FAM3D	Family with sequence similarity 3 member D. (228 aa)
	LOC102362376	Protein kinase domain containing, cytoplasmic b. (381 aa)
	BAG4	BCL2 associated athanogene 4. (454 aa)
	BAG3	BCL2 associated athanogene 3. (561 aa)
	NDFIP1	Nedd4 family interacting protein 1. (212 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	NDUFAF2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (167 aa)
	SERGEF	Secretion regulating guanine nucleotide exchange factor. (406 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	SYT4	Synaptotagmin 4. (434 aa)
	RANGAP1	Ran GTPase activating protein 1. (615 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1225 aa)
	GHRL	Motilin_assoc domain-containing protein. (110 aa)
	UBE2G2	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	KLF7	Kruppel like factor 7. (294 aa)
	RHBDF2	Rhomboid 5 homolog 2. (869 aa)
	INHBB	Inhibin subunit beta B. (393 aa)
	SYTL4	Synaptotagmin like 4. (641 aa)
	SNX3	Sorting nexin 3. (108 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (503 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1591 aa)
	KCNB1	Potassium voltage-gated channel, Shab-related subfamily, member 1; Belongs to the potassium channel family. (677 aa)
	KCNJ11	Potassium voltage-gated channel subfamily J member 11. (392 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	NF1	Neurofibromin 1. (2814 aa)
	RHBDF1	Rhomboid 5 homolog 1. (805 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (497 aa)
	NDFIP2	Nedd4 family interacting protein 2. (175 aa)
	DERL2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	OS9	OS9 endoplasmic reticulum lectin. (662 aa)
	H3BFU5_LATCH	AIP3 domain-containing protein. (914 aa)
	PSMD9	Proteasome 26S subunit, non-ATPase 9. (210 aa)
	SIRT4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	YOD1	YOD1 deubiquitinase. (304 aa)
	BARD1	BRCA1 associated RING domain 1. (866 aa)
	APOD	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC8	GOPC	ENSLACP00000018585	ENSLACP00000007827	ATP binding cassette subfamily C member 8.	Golgi-associated PDZ and coiled-coil motif containing.	0.507
ABCC8	KCNJ11	ENSLACP00000018585	ENSLACP00000018990	ATP binding cassette subfamily C member 8.	Potassium voltage-gated channel subfamily J member 11.	0.999
ABCC8	SERGEF	ENSLACP00000018585	ENSLACP00000014338	ATP binding cassette subfamily C member 8.	Secretion regulating guanine nucleotide exchange factor.	0.428
ACVR1C	INHBB	ENSLACP00000009358	ENSLACP00000017782	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin subunit beta B.	0.984
ADIPOQ	GHRL	ENSLACP00000000452	ENSLACP00000015917	Adiponectin, C1Q and collagen domain containing.	Motilin_assoc domain-containing protein.	0.542
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
BAG3	BAG4	ENSLACP00000012843	ENSLACP00000012598	BCL2 associated athanogene 3.	BCL2 associated athanogene 4.	0.563
BAG3	NDFIP1	ENSLACP00000012843	ENSLACP00000012935	BCL2 associated athanogene 3.	Nedd4 family interacting protein 1.	0.420
BAG3	NDFIP2	ENSLACP00000012843	ENSLACP00000020152	BCL2 associated athanogene 3.	Nedd4 family interacting protein 2.	0.420
BAG4	BAG3	ENSLACP00000012598	ENSLACP00000012843	BCL2 associated athanogene 4.	BCL2 associated athanogene 3.	0.563
BARD1	UBE2J1	ENSLACP00000022324	ENSLACP00000011151	BRCA1 associated RING domain 1.	Ubiquitin conjugating enzyme E2 J1.	0.538
DERL2	ERLEC1	ENSLACP00000020713	ENSLACP00000007837	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.937
DERL2	OS9	ENSLACP00000020713	ENSLACP00000020725	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.937
DERL2	UBE2G2	ENSLACP00000020713	ENSLACP00000016288	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.439
DERL2	UBE2J1	ENSLACP00000020713	ENSLACP00000011151	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 J1.	0.512
DERL3	ERLEC1	ENSLACP00000011180	ENSLACP00000007837	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.937
DERL3	OS9	ENSLACP00000011180	ENSLACP00000020725	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.937
DERL3	UBE2G2	ENSLACP00000011180	ENSLACP00000016288	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.439
DERL3	UBE2J1	ENSLACP00000011180	ENSLACP00000011151	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 J1.	0.512
DRD2	DRD4	ENSLACP00000020922	ENSLACP00000016532	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.731