STRINGSTRING
MAD2L1 MAD2L1 LOC102348760 LOC102348760 CDK5RAP3 CDK5RAP3 DUSP19 DUSP19 AIDA AIDA LOC102351081 LOC102351081 SIRT1 SIRT1 ITGB1BP1 ITGB1BP1 PTPRQ PTPRQ PRKAR2B PRKAR2B PINX1 PINX1 SH3BP5L SH3BP5L CDKN1A CDKN1A LATS2 LATS2 MIDN MIDN LOC102349920 LOC102349920 HMGCR HMGCR SMCR8 SMCR8 CBLB CBLB FBXO5 FBXO5 SPRY2 SPRY2 LATS1 LATS1 BAG5 BAG5 TSG101 TSG101 CAMK2N2 CAMK2N2 SH3BP5 SH3BP5 LOC102367007 LOC102367007 AJUBA AJUBA SORL1 SORL1 PSEN1 PSEN1 GSK3B GSK3B H3ATR3_LATCH H3ATR3_LATCH SPRED1 SPRED1 DTNBP1 DTNBP1 MACROH2A1 MACROH2A1 DEPTOR DEPTOR DDR2 DDR2 H3AW40_LATCH H3AW40_LATCH RUBCN RUBCN CDKN1B CDKN1B PRKAR1B PRKAR1B SPRY4 SPRY4 PIP4K2A PIP4K2A H3AWW7_LATCH H3AWW7_LATCH CAV1 CAV1 SPRY3 SPRY3 CDK5RAP1 CDK5RAP1 H3AYV3_LATCH H3AYV3_LATCH H3AYV7_LATCH H3AYV7_LATCH PIK3CB PIK3CB C1QTNF9 C1QTNF9 SH2B3 SH2B3 FBXO7 FBXO7 CHORDC1 CHORDC1 CDKN2D CDKN2D PPM1F PPM1F CDKN1C CDKN1C TP53 TP53 MYOCD MYOCD COX11 COX11 BMP2 BMP2 LOC102365218 LOC102365218 H3B354_LATCH H3B354_LATCH TNFAIP3 TNFAIP3 PRDX3 PRDX3 LOC102366507 LOC102366507 MSTN MSTN RACK1 RACK1 LOC102361687 LOC102361687 SPRY1 SPRY1 CHMP6 CHMP6 NPRL2 NPRL2 SMYD3 SMYD3 DUSP10 DUSP10 PRKAR1A PRKAR1A LOC102362769 LOC102362769 RTRAF RTRAF PIK3IP1 PIK3IP1 LOC102346019 LOC102346019 CEP85 CEP85 NF1 NF1 PRKAR2A PRKAR2A PARP3 PARP3 TEN1 TEN1 HIPK3 HIPK3 PRKRIP1 PRKRIP1 CBL CBL AKT1S1 AKT1S1 H3BFU5_LATCH H3BFU5_LATCH LRP6 LRP6 CAV3 CAV3 PIP4K2C PIP4K2C CAMK2N1 CAMK2N1 LRP5 LRP5 DBNDD2 DBNDD2 LOC102358538 LOC102358538 LOC102355265 LOC102355265 UBASH3B UBASH3B SOCS4 SOCS4 BMP4 BMP4 MAD2L2 MAD2L2 ADAR ADAR FAM72A FAM72A AGT AGT THY1 THY1 NF2 NF2 HSPB1 HSPB1 PAQR3 PAQR3 INPP5K INPP5K TMEM130 TMEM130 MVP MVP GSK3A GSK3A SFRP2 SFRP2 POT1 POT1 GBA GBA GCKR GCKR ERRFI1 ERRFI1 CHP1 CHP1 SMAD7 SMAD7 TRIB3 TRIB3 LYN LYN CDKN2C CDKN2C QARS1 QARS1 PTPN2 PTPN2 BAG2 BAG2 PHPT1 PHPT1 RB1 RB1 DBNDD1 DBNDD1 PLK1 PLK1 PPM1E PPM1E PTPN1 PTPN1 LOC102363052 LOC102363052 LOC102349442 LOC102349442 PTPRB PTPRB SMPD1 SMPD1 HEXIM1 HEXIM1 WARS1 WARS1 PIP4K2B PIP4K2B PTPRC PTPRC H3A180_LATCH H3A180_LATCH ZGPAT ZGPAT SOCS5 SOCS5 PTPN6 PTPN6 USP44 USP44 LOC102354291 LOC102354291 NCAPG2 NCAPG2 ZFYVE28 ZFYVE28 FGFR1OP FGFR1OP IRAK3 IRAK3 LOC102356560 LOC102356560 PTPRO PTPRO BUB3 BUB3 PIF1 PIF1 ADIPOQ ADIPOQ LOC102356912 LOC102356912 TFAP4 TFAP4 TSC2 TSC2 LOC102349364 LOC102349364
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAD2L1Mitotic arrest deficient 2 like 1. (202 aa)
LOC102348760Uncharacterized protein. (782 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (519 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (213 aa)
AIDAAxin interactor, dorsalization associated. (304 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
SIRT1Sirtuin 1. (729 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (1795 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (404 aa)
PINX1Uncharacterized protein. (244 aa)
SH3BP5LSH3 binding domain protein 5 like. (259 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (171 aa)
LATS2Large tumor suppressor kinase 2. (1108 aa)
MIDNMidnolin. (524 aa)
LOC102349920Uncharacterized protein. (199 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
CBLBCbl proto-oncogene B. (827 aa)
FBXO5F-box protein 5. (313 aa)
SPRY2Sprouty RTK signaling antagonist 2. (320 aa)
LATS1Large tumor suppressor kinase 1. (1140 aa)
BAG5BCL2 associated athanogene 5. (460 aa)
TSG101Tumor susceptibility 101. (392 aa)
CAMK2N2Uncharacterized protein. (79 aa)
SH3BP5SH3 domain binding protein 5. (278 aa)
LOC102367007Uncharacterized protein. (335 aa)
AJUBAUncharacterized protein. (526 aa)
SORL1Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
H3ATR3_LATCHSuppressor of cytokine signaling 9. (442 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
DTNBP1Dystrobrevin binding protein 1. (355 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (370 aa)
DEPTORDEP domain containing MTOR interacting protein. (369 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (838 aa)
H3AW40_LATCHFYVE-type domain-containing protein. (927 aa)
RUBCNRubicon autophagy regulator. (924 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (383 aa)
SPRY4Sprouty RTK signaling antagonist 4. (282 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (334 aa)
H3AWW7_LATCHUncharacterized protein. (515 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
SPRY3Sprouty RTK signaling antagonist 3. (296 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (587 aa)
H3AYV3_LATCHUncharacterized protein. (962 aa)
H3AYV7_LATCHUncharacterized protein. (253 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
C1QTNF9C1q domain-containing protein. (198 aa)
SH2B3SH2B adaptor protein 3. (583 aa)
FBXO7F-box protein 7. (482 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (337 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (168 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (444 aa)
CDKN1CUncharacterized protein. (215 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
MYOCDMyocardin. (963 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (273 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
LOC102365218Uncharacterized protein. (210 aa)
H3B354_LATCHUncharacterized protein. (850 aa)
TNFAIP3TNF alpha induced protein 3. (785 aa)
PRDX3Peroxiredoxin 3. (254 aa)
LOC102366507Uncharacterized protein. (316 aa)
MSTNMyostatin. (372 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
LOC102361687Uncharacterized protein. (188 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
CHMP6Charged multivesicular body protein 6. (146 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
SMYD3SET and MYND domain containing 3. (239 aa)
DUSP10Dual specificity phosphatase 10. (481 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
LOC102362769Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
RTRAFRNA transcription, translation and transport factor. (245 aa)
PIK3IP1Phosphoinositide-3-kinase interacting protein 1. (261 aa)
LOC102346019C1q domain-containing protein. (226 aa)
CEP85Centrosomal protein 85. (779 aa)
NF1Neurofibromin 1. (2814 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (402 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
TEN1TEN1 subunit of CST complex. (123 aa)
HIPK3Homeodomain interacting protein kinase 3. (1204 aa)
PRKRIP1PRKR interacting protein 1. (184 aa)
CBLCbl proto-oncogene. (903 aa)
AKT1S1AKT1 substrate 1. (285 aa)
H3BFU5_LATCHAIP3 domain-containing protein. (914 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (305 aa)
CAMK2N1Calcium/calmodulin dependent protein kinase II inhibitor 1. (79 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
DBNDD2Si:ch211-253b8.5. (195 aa)
LOC102358538Growth differentiation factor 11. (381 aa)
LOC102355265Neurofibromin 2b (merlin). (577 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (607 aa)
SOCS4Suppressor of cytokine signaling 4. (406 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (212 aa)
ADARAdenosine deaminase RNA specific. (1150 aa)
FAM72AUncharacterized protein. (147 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
THY1Thy-1 cell surface antigen. (165 aa)
NF2Neurofibromin 2. (595 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (219 aa)
PAQR3Uncharacterized protein. (175 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (476 aa)
TMEM130Transmembrane protein 130. (417 aa)
MVPMajor vault protein. (856 aa)
GSK3AGlycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (463 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
POT1Protection of telomeres 1. (791 aa)
GBAGlucosylceramidase. (517 aa)
GCKRGlucokinase regulator. (346 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (468 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
TRIB3Tribbles pseudokinase 3. (353 aa)
LYNTyrosine-protein kinase. (515 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (169 aa)
QARS1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (769 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (397 aa)
BAG2BCL2 associated athanogene 2. (212 aa)
PHPT1Phosphohistidine phosphatase 1. (120 aa)
RB1Uncharacterized protein. (411 aa)
DBNDD1Dysbindin domain containing 1. (161 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
PPM1EProtein phosphatase, Mg2+/Mn2+ dependent 1E. (611 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (439 aa)
LOC102363052Si:dkey-3h3.3. (215 aa)
LOC102349442Uncharacterized protein. (219 aa)
PTPRBProtein tyrosine phosphatase receptor type B. (2131 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (396 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (196 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (372 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (830 aa)
H3A180_LATCHRING-type domain-containing protein. (366 aa)
ZGPATZinc finger, CCCH-type with G patch domain. (537 aa)
SOCS5Suppressor of cytokine signaling 5. (538 aa)
PTPN6Protein tyrosine phosphatase non-receptor type 6. (338 aa)
USP44Ubiquitin carboxyl-terminal hydrolase. (714 aa)
LOC102354291Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1154 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (878 aa)
FGFR1OPFGFR1 oncogene partner. (467 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (546 aa)
LOC102356560ANK_REP_REGION domain-containing protein. (128 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1222 aa)
BUB3BUB3 mitotic checkpoint protein. (361 aa)
PIF1ATP-dependent DNA helicase; Belongs to the helicase family. (630 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (259 aa)
LOC102356912ANK_REP_REGION domain-containing protein. (185 aa)
TFAP4Transcription factor AP-4. (350 aa)
TSC2TSC complex subunit 2. (1836 aa)
LOC102349364Si:dkey-51e6.1. (145 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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