(42 nodes) Neuron apoptotic process network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	DLX1	Distal-less homeobox 1. (253 aa)
	CLN8	CLN8 transmembrane ER and ERGIC protein. (294 aa)
	LIG4	DNA ligase. (911 aa)
	RB1	Uncharacterized protein. (411 aa)
	ATM	ATM serine/threonine kinase. (2375 aa)
	AARS1	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (968 aa)
	DNAJC5B	DnaJ heat shock protein family (Hsp40) member C5 beta. (197 aa)
	BAX	Uncharacterized protein. (223 aa)
	H3AHH6_LATCH	RHD domain-containing protein. (288 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	BOK	BCL2 family apoptosis regulator BOK. (111 aa)
	FADD	Fas associated via death domain. (193 aa)
	ADNP	Activity dependent neuroprotector homeobox. (1116 aa)
	NCSTN	Nicastrin. (680 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (536 aa)
	DNAJC5G	J domain-containing protein. (116 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	TMTC4	Transmembrane O-mannosyltransferase targeting cadherins 4. (743 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2438 aa)
	OXR1	Oxidation resistance 1. (840 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1202 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	NTRK1	Tyrosine-protein kinase receptor. (747 aa)
	TNFRSF21	TNF receptor superfamily member 21. (651 aa)
	SNCB	Beta-synuclein; Belongs to the synuclein family. (133 aa)
	NEFL	Neurofilament light; Belongs to the intermediate filament family. (555 aa)
	NF1	Neurofibromin 1. (2814 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	DIABLO	Diablo, IAP-binding mitochondrial protein b. (257 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (457 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2066 aa)
	PIGT	Phosphatidylinositol glycan anchor biosynthesis class T. (586 aa)
	RAPSN	Receptor associated protein of the synapse. (420 aa)
	DRAXIN	Dorsal inhibitory axon guidance protein. (347 aa)
	TP63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (313 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AARS1	NF1	ENSLACP00000005503	ENSLACP00000019331	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	Neurofibromin 1.	0.579
AIFM1	APAF1	ENSLACP00000001333	ENSLACP00000014568	Apoptosis inducing factor mitochondria associated 1.	Apoptotic peptidase activating factor 1.	0.551
AIFM1	BAX	ENSLACP00000001333	ENSLACP00000007049	Apoptosis inducing factor mitochondria associated 1.	Uncharacterized protein.	0.922
AIFM1	CASP9	ENSLACP00000001333	ENSLACP00000020786	Apoptosis inducing factor mitochondria associated 1.	Caspase 9; Belongs to the peptidase C14A family.	0.587
AIFM1	DIABLO	ENSLACP00000001333	ENSLACP00000020692	Apoptosis inducing factor mitochondria associated 1.	Diablo, IAP-binding mitochondrial protein b.	0.578
AIFM1	NCSTN	ENSLACP00000001333	ENSLACP00000010981	Apoptosis inducing factor mitochondria associated 1.	Nicastrin.	0.424
APAF1	AIFM1	ENSLACP00000014568	ENSLACP00000001333	Apoptotic peptidase activating factor 1.	Apoptosis inducing factor mitochondria associated 1.	0.551
APAF1	ATM	ENSLACP00000014568	ENSLACP00000005407	Apoptotic peptidase activating factor 1.	ATM serine/threonine kinase.	0.441
APAF1	BAX	ENSLACP00000014568	ENSLACP00000007049	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.800
APAF1	BOK	ENSLACP00000014568	ENSLACP00000009914	Apoptotic peptidase activating factor 1.	BCL2 family apoptosis regulator BOK.	0.670
APAF1	CASP7	ENSLACP00000014568	ENSLACP00000022676	Apoptotic peptidase activating factor 1.	Caspase 7; Belongs to the peptidase C14A family.	0.877
APAF1	CASP9	ENSLACP00000014568	ENSLACP00000020786	Apoptotic peptidase activating factor 1.	Caspase 9; Belongs to the peptidase C14A family.	0.995
APAF1	DIABLO	ENSLACP00000014568	ENSLACP00000020692	Apoptotic peptidase activating factor 1.	Diablo, IAP-binding mitochondrial protein b.	0.990
APAF1	FADD	ENSLACP00000014568	ENSLACP00000009943	Apoptotic peptidase activating factor 1.	Fas associated via death domain.	0.659
APAF1	NAE1	ENSLACP00000014568	ENSLACP00000011007	Apoptotic peptidase activating factor 1.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.481
APAF1	TP53	ENSLACP00000014568	ENSLACP00000015915	Apoptotic peptidase activating factor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.790
APAF1	TP63	ENSLACP00000014568	ENSLACP00000022643	Apoptotic peptidase activating factor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.626
APP	CDK5	ENSLACP00000001643	ENSLACP00000009607	Amyloid beta precursor protein.	Cyclin dependent kinase 5.	0.540
APP	NAE1	ENSLACP00000001643	ENSLACP00000011007	Amyloid beta precursor protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.735
APP	NCSTN	ENSLACP00000001643	ENSLACP00000010981	Amyloid beta precursor protein.	Nicastrin.	0.952